61 research outputs found
Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat
Peer reviewedPublisher PD
An ultraviolet-optical flare from the tidal disruption of a helium-rich stellar core
The flare of radiation from the tidal disruption and accretion of a star can
be used as a marker for supermassive black holes that otherwise lie dormant and
undetected in the centres of distant galaxies. Previous candidate flares have
had declining light curves in good agreement with expectations, but with poor
constraints on the time of disruption and the type of star disrupted, because
the rising emission was not observed. Recently, two `relativistic' candidate
tidal disruption events were discovered, each of whose extreme X-ray luminosity
and synchrotron radio emission were interpreted as the onset of emission from a
relativistic jet. Here we report the discovery of a luminous
ultraviolet-optical flare from the nuclear region of an inactive galaxy at a
redshift of 0.1696. The observed continuum is cooler than expected for a simple
accreting debris disk, but the well-sampled rise and decline of its light curve
follows the predicted mass accretion rate, and can be modelled to determine the
time of disruption to an accuracy of two days. The black hole has a mass of
about 2 million solar masses, modulo a factor dependent on the mass and radius
of the star disrupted. On the basis of the spectroscopic signature of ionized
helium from the unbound debris, we determine that the disrupted star was a
helium-rich stellar core.Comment: To appear in Nature on May 10, 201
Discovery of the Onset of Rapid Accretion by a Dormant Massive Black Hole
Massive black holes are believed to reside at the centres of most galaxies.
They can be- come detectable by accretion of matter, either continuously from a
large gas reservoir or impulsively from the tidal disruption of a passing star,
and conversion of the gravitational energy of the infalling matter to light.
Continuous accretion drives Active Galactic Nuclei (AGN), which are known to be
variable but have never been observed to turn on or off. Tidal disruption of
stars by dormant massive black holes has been inferred indirectly but the on-
set of a tidal disruption event has never been observed. Here we report the
first discovery of the onset of a relativistic accretion-powered jet in the new
extragalactic transient, Swift J164449.3+573451. The behaviour of this new
source differs from both theoretical models of tidal disruption events and
observations of the jet-dominated AGN known as blazars. These differences may
stem from transient effects associated with the onset of a powerful jet. Such
an event in the massive black hole at the centre of our Milky Way galaxy could
strongly ionize the upper atmosphere of the Earth, if beamed towards us.Comment: Submitted to Nature. 4 pages, 3 figures (main paper). 26 pages, 13
figures (supplementary information
Debris Disks: Probing Planet Formation
Debris disks are the dust disks found around ~20% of nearby main sequence
stars in far-IR surveys. They can be considered as descendants of
protoplanetary disks or components of planetary systems, providing valuable
information on circumstellar disk evolution and the outcome of planet
formation. The debris disk population can be explained by the steady
collisional erosion of planetesimal belts; population models constrain where
(10-100au) and in what quantity (>1Mearth) planetesimals (>10km in size)
typically form in protoplanetary disks. Gas is now seen long into the debris
disk phase. Some of this is secondary implying planetesimals have a Solar
System comet-like composition, but some systems may retain primordial gas.
Ongoing planet formation processes are invoked for some debris disks, such as
the continued growth of dwarf planets in an unstirred disk, or the growth of
terrestrial planets through giant impacts. Planets imprint structure on debris
disks in many ways; images of gaps, clumps, warps, eccentricities and other
disk asymmetries, are readily explained by planets at >>5au. Hot dust in the
region planets are commonly found (<5au) is seen for a growing number of stars.
This dust usually originates in an outer belt (e.g., from exocomets), although
an asteroid belt or recent collision is sometimes inferred.Comment: Invited review, accepted for publication in the 'Handbook of
Exoplanets', eds. H.J. Deeg and J.A. Belmonte, Springer (2018
Octopus, a computational framework for exploring light-driven phenomena and quantum dynamics in extended and finite systems
Over the last few years, extraordinary advances in experimental and theoretical tools have allowed us to monitor and control matter at short time and atomic scales with a high degree of precision. An appealing and challenging route toward engineering materials with tailored properties is to find ways to design or selectively manipulate materials, especially at the quantum level. To this end, having a state-of-the-art ab initio computer simulation tool that enables a reliable and accurate simulation of light-induced changes in the physical and chemical properties of complex systems is of utmost importance. The first principles real-space-based Octopus project was born with that idea in mind, i.e., to provide a unique framework that allows us to describe non-equilibrium phenomena in molecular complexes, low dimensional materials, and extended systems by accounting for electronic, ionic, and photon quantum mechanical effects within a generalized time-dependent density functional theory. This article aims to present the new features that have been implemented over the last few years, including technical developments related to performance and massive parallelism. We also describe the major theoretical developments to address ultrafast light-driven processes, such as the new theoretical framework of quantum electrodynamics density-functional formalism for the description of novel light-matter hybrid states. Those advances, and others being released soon as part of the Octopus package, will allow the scientific community to simulate and characterize spatial and time-resolved spectroscopies, ultrafast phenomena in molecules and materials, and new emergent states of matter (quantum electrodynamical-materials)
Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance
OBJECTIVE: The hypothalamic control of energy balance is regulated by a complex network of neuropeptide-releasing neurons. Whilst the effect of these neuropeptides on individual aspects of energy homeostasis has been studied, the coordinated response of these effects has not been comprehensively investigated. We have simultaneously monitored a number of metabolic parameters following ICV administration of 1nmol and 3nmol of neuropeptides with established roles in the regulation of feeding, activity and metabolism. Ad libitum fed rats received the orexigenic neuropeptides neuropeptide Y (NPY), agouti-related protein (AgRP), melanin-concentrating hormone (MCH) or orexin-A. Overnight food deprived rats received an ICV injection of the anorectic peptides α-MSH, corticotrophin releasing factor (CRF) or neuromedin U (NMU). RESULTS: Our results reveal the temporal sequence of the effects of these neuropeptides on both energy intake and expenditure, highlighting key differences in their function as mediators of energy balance. NPY and AgRP increased feeding and decreased oxygen consumption, with the effects of AgRP being more prolonged. In contrast, orexin-A increased both feeding and oxygen consumption, consistent with an observed increase in activity. The potent anorexigenic effects of CRF were accompanied by a prolonged increase in activity whilst NMU injection resulted in significant but short-lasting inhibition of food intake, ambulatory activity and oxygen consumption. Alpha-MSH injection resulted in significant increases in both ambulatory activity and oxygen consumption, and reduced food intake following administration of 3nmol of the peptide. CONCLUSION: We have for the first time, simultaneously measured several metabolic parameters following hypothalamic administration of a number of neuropeptides within the same experimental system. This work has demonstrated the interrelated effects of these neuropeotides on activity, energy expenditure and food intake thus facilitating comparison between the different hypothalamic systems
The Birth of a Relativistic Outflow in the Unusual {\gamma}-ray Transient Swift J164449.3+573451
Active galactic nuclei (AGN), powered by long-term accretion onto central
supermassive black holes, produce relativistic jets with lifetimes of greater
than one million yr that preclude observations at birth. Transient accretion
onto a supermassive black hole, for example through the tidal disruption of a
stray star, may therefore offer a unique opportunity to observe and study the
birth of a relativistic jet. On 2011 March 25, the Swift {\gamma}-ray satellite
discovered an unusual transient source (Swift J164449.3+573451) potentially
representing such an event. Here we present the discovery of a luminous radio
transient associated with Swift J164449.3+573451, and an extensive set of
observations spanning centimeter to millimeter wavelengths and covering the
first month of evolution. These observations lead to a positional coincidence
with the nucleus of an inactive galaxy, and provide direct evidence for a
newly-formed relativistic outflow, launched by transient accretion onto a
million solar mass black hole. While a relativistic outflow was not predicted
in this scenario, we show that the tidal disruption of a star naturally
explains the high-energy properties, radio luminosity, and the inferred rate of
such events. The weaker beaming in the radio compared to {\gamma}-rays/X-rays,
suggests that radio searches may uncover similar events out to redshifts of z ~
6.Comment: 24 pages, 5 figures, 2 table
Octopus, a computational framework for exploring light-driven phenomena and quantum dynamics in extended and finite systems
Over the last few years, extraordinary advances in experimental and theoretical tools have allowed us to monitor and control matter at short time and atomic scales with a high degree of precision. An appealing and challenging route toward engineering materials with tailored properties is to find ways to design or selectively manipulate materials, especially at the quantum level. To this end, having a state-of-the-art ab initio computer simulation tool that enables a reliable and accurate simulation of light-induced changes in the physical and chemical properties of complex systems is of utmost importance. The first principles real-space-based Octopus project was born with that idea in mind, i.e., to provide a unique framework that allows us to describe non-equilibrium phenomena in molecular complexes, low dimensional materials, and extended systems by accounting for electronic, ionic, and photon quantum mechanical effects within a generalized time-dependent density functional theory. This article aims to present the new features that have been implemented over the last few years, including technical developments related to performance and massive parallelism. We also describe the major theoretical developments to address ultrafast light-driven processes, such as the new theoretical framework of quantum electrodynamics density-functional formalism for the description of novel light–matter hybrid states. Those advances, and others being released soon as part of the Octopus package, will allow the scientific community to simulate and characterize spatial and time-resolved spectroscopies, ultrafast phenomena in molecules and materials, and new emergent states of matter (quantum electrodynamical-materials).This work was supported by the European Research Council (Grant No. ERC-2015-AdG694097), the Cluster of Excellence “Advanced Imaging of Matter” (AIM), Grupos Consolidados (IT1249-19), and SFB925. The Flatiron Institute is a division of the Simons Foundation. X.A., A.W., and A.C. acknowledge that part of this work was performed under the auspices of the U.S. Department of Energy at Lawrence Livermore National Laboratory under Contract No. DE-AC52-07A27344. J.J.-S. gratefully acknowledges the funding from the European Union Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie Grant Agreement No. 795246-StrongLights. J.F. acknowledges financial support from the Deutsche Forschungsgemeinschaft (DFG Forschungsstipendium FL 997/1-1). D.A.S. acknowledges University of California, Merced start-up funding.Peer reviewe
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