344 research outputs found
The shape of the CMB lensing bispectrum
Lensing of the CMB generates a significant bispectrum, which should be
detected by the Planck satellite at the 5-sigma level and is potentially a
non-negligible source of bias for f_NL estimators of local non-Gaussianity. We
extend current understanding of the lensing bispectrum in several directions:
(1) we perform a non-perturbative calculation of the lensing bispectrum which
is ~10% more accurate than previous, first-order calculations; (2) we
demonstrate how to incorporate the signal variance of the lensing bispectrum
into estimates of its amplitude, providing a good analytical explanation for
previous Monte-Carlo results; and (3) we discover the existence of a
significant lensing bispectrum in polarization, due to a previously-unnoticed
correlation between the lensing potential and E-polarization as large as 30% at
low multipoles. We use this improved understanding of the lensing bispectra to
re-evaluate Fisher-matrix predictions, both for Planck and cosmic variance
limited data. We confirm that the non-negligible lensing-induced bias for
estimation of local non-Gaussianity should be robustly treatable, and will only
inflate f_NL error bars by a few percent over predictions where lensing effects
are completely ignored (but note that lensing must still be accounted for to
obtain unbiased constraints). We also show that the detection significance for
the lensing bispectrum itself is ultimately limited to 9 sigma by cosmic
variance. The tools that we develop for non-perturbative calculation of the
lensing bispectrum are directly relevant to other calculations, and we give an
explicit construction of a simple non-perturbative quadratic estimator for the
lensing potential and relate its cross-correlation power spectrum to the
bispectrum. Our numerical codes are publicly available as part of CAMB and
LensPix.Comment: 32 pages, 10 figures; minor changes to match JCAP-accepted version.
CMB lensing and primordial local bispectrum codes available as part of CAMB
(http://camb.info/
Induced CMB quadrupole from pointing offsets
Recent claims in the literature have suggested that the {\it WMAP} quadrupole
is not primordial in origin, and arises from an aliasing of the much larger
dipole field because of incorrect satellite pointing. We attempt to reproduce
this result and delineate the key physics leading to the effect. We find that,
even if real, the induced quadrupole would be smaller than claimed. We discuss
reasons why the {\it WMAP} data are unlikely to suffer from this particular
systematic effect, including the implications for observations of point
sources. Given this evidence against the reality of the effect, the similarity
between the pointing-offset-induced signal and the actual quadrupole then
appears to be quite puzzling. However, we find that the effect arises from a
convolution between the gradient of the dipole field and anisotropic coverage
of the scan direction at each pixel. There is something of a directional
conspiracy here -- the dipole signal lies close to the Ecliptic Plane, and its
direction, together with the {\it WMAP} scan strategy, results in a strong
coupling to the component in Ecliptic co-ordinates. The dominant
strength of this component in the measured quadrupole suggests that one should
exercise increased caution in interpreting its estimated amplitude. The {\it
Planck} satellite has a different scan strategy which does not so directly
couple the dipole and quadrupole in this way and will soon provide an
independent measurement.Comment: 8 pages, 4 figure
Spin interactions of interstitial Mn ions in ferromagnetic GaMnAs
The recently reported Rutherford backscattering and particle-induced X-ray
emission experiments have revealed that in low-temperature MBE grown GaMnAs a
significant part of the incorporated Mn atoms occupies tetrahedral interstitial
sites in the lattice. Here we study the magnetic properties of these
interstitial ions. We show that they do not participate in the hole-induced
ferromagnetism. Moreover, Mn interstitial double donors may form pairs with the
nearest substitutional Mn acceptors - our calculations evidence that the spins
in such pairs are antiferromagnetically coupled by the superexchange. We also
show that for the Mn ion in the other, hexagonal, interstitial position (which
seems to be the case in the GaMnBeAs samples) the p-d interactions with the
holes, responsible for the ferromagnetism, are very much suppressed.Comment: 4 pages, 3 figures, submitted to PR
Probing Cosmic Strings with Satellite CMB measurements
We study the problem of searching for cosmic string signal patterns in the
present high resolution and high sensitivity observations of the Cosmic
Microwave Background (CMB). This article discusses a technique capable of
recognizing Kaiser-Stebbins effect signatures in total intensity anisotropy
maps, and shows that the biggest factor that produces confusion is represented
by the acoustic oscillation features of the scale comparable to the size of
horizon at recombination. Simulations show that the distribution of null
signals for pure Gaussian maps converges to a distribution, with
detectability threshold corresponding to a string induced step signal with an
amplitude of about 100 \muK which corresponds to a limit of roughly . We study the statistics of spurious detections caused by
extra-Galactic and Galactic foregrounds. For diffuse Galactic foregrounds,
which represents the dominant source of contamination, we derive sky masks
outlining the available region of the sky where the Galactic confusion is
sub-dominant, specializing our analysis to the case represented by the
frequency coverage and nominal sensitivity and resolution of the Planck
experiment.Comment: 14 pages, 3 figures, to be published in JCA
No evidence for anomalously low variance circles on the sky
In a recent paper, Gurzadyan & Penrose claim to have found directions on the
sky centred on which are circles of anomalously low variance in the cosmic
microwave background (CMB). These features are presented as evidence for a
particular picture of the very early Universe. We attempted to repeat the
analysis of these authors, and we can indeed confirm that such variations do
exist in the temperature variance for annuli around points in the data.
However, we find that this variation is entirely expected in a sky which
contains the usual CMB anisotropies. In other words, properly simulated
Gaussian CMB data contain just the sorts of variations claimed. Gurzadyan &
Penrose have not found evidence for pre-Big Bang phenomena, but have simply
re-discovered that the CMB contains structure.Comment: 4 pages, 4 figures, v3 accepted by JCA
Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Copenhagen, Denmark. [email protected] BACKGROUND: Stimulation of energy expenditure (EE) with selective thermogenic beta-adrenergic agonists may be a promising approach for treating obesity. OBJECTIVE: We analyzed the effects of the highly selective human beta(3)-adrenergic agonist L-796568 on 24-h EE, substrate oxidation, and body composition in obese, weight-stable men. DESIGN: In this 2-center, double-blind, randomized, parallel-group study, we measured 24-h EE before and after 28 d of treatment with L-796568 (375 mg/d) or placebo during weight maintenance (ie, without dietary intervention) in nondiabetic, nonsmoking men aged 25-49 y with body mass index (in kg/m(2)) of 28-35 (n = 10 subjects per treatment group). RESULTS: The mean change in 24-h EE from before to after treatment did not differ significantly between groups (92 +/- 586 and 86 +/- 512 kJ/24 h for the L-796568 and placebo groups, respectively). The change in 24-h nonprotein respiratory quotient from before to after treatment did not differ significantly between groups (0.009 +/- 0.021 and 0.009 +/- 0.029, respectively). No changes in glucose tolerance were observed, but triacylglycerol concentrations decreased significantly with L-796568 treatment compared with placebo (-0.76 +/- 0.76 and 0.42 +/- 0.31 mmol/L, respectively; P < 0.002). Overall, treatment-related changes in body composition were not observed, but higher plasma L-796568 concentrations in the L-796568 group were associated with greater decreases in fat mass (r = -0.69, P < 0.03). CONCLUSIONS: Treatment with L-796568 for 28 d had no major lipolytic or thermogenic effect but it lowered triacylglycerol concentrations. This lack of chronic effect on energy balance is likely explained by insufficient recruitment of beta(3)-responsive tissues in humans, down-regulation of the beta(3)-adrenergic receptor-mediated effects with chronic dosing, or both. Publication Types: Clinical Trial Randomized Controlled Tria
Training for interdisciplinary health research defining the required competencies
Although interdisciplinary research is becoming the dominant model for understanding complex health issues, little is known about the competencies required for successful interdisciplinary collaboration. Published research has discussed attitudes about interdisciplinary work and organizational resources but not the needed competencies. This report describes the method and results of the competency specification process for health research. Based on an established definition of interdisciplinary research, a preliminary set of competencies was developed from expert opinion of key informants and a review of the interdisciplinary research literature. A Delphi panel of interdisciplinary researchers then reached consensus on 17 competencies necessary for interdisciplinary research
Asymmetric Dark Matter and Dark Radiation
Asymmetric Dark Matter (ADM) models invoke a particle-antiparticle asymmetry,
similar to the one observed in the Baryon sector, to account for the Dark
Matter (DM) abundance. Both asymmetries are usually generated by the same
mechanism and generally related, thus predicting DM masses around 5 GeV in
order to obtain the correct density. The main challenge for successful models
is to ensure efficient annihilation of the thermally produced symmetric
component of such a light DM candidate without violating constraints from
collider or direct searches. A common way to overcome this involves a light
mediator, into which DM can efficiently annihilate and which subsequently
decays into Standard Model particles. Here we explore the scenario where the
light mediator decays instead into lighter degrees of freedom in the dark
sector that act as radiation in the early Universe. While this assumption makes
indirect DM searches challenging, it leads to signals of extra radiation at BBN
and CMB. Under certain conditions, precise measurements of the number of
relativistic species, such as those expected from the Planck satellite, can
provide information on the structure of the dark sector. We also discuss the
constraints of the interactions between DM and Dark Radiation from their
imprint in the matter power spectrum.Comment: 22 pages, 5 figures, to be published in JCAP, minor changes to match
version to be publishe
Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium
Aims Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, but their impact on OH remains unknown. Methods and resultsA total of 38 970 men and women of European ancestry from five population-based cohorts were included, of whom 2656 (6.8) met the diagnostic criteria for OH (systolic/diastolic BP drop <20/10 mmHg within 3 min of standing). Thirty-one recently discovered BP-associated single nucleotide polymorphisms (SNPs) were examined using an additive genetic model and the major allele as referent. Relations between OH, orthostatic systolic BP response, and genetic variants were assessed by inverse variance-weighted meta-analysis. We found Bonferroni adjusted (P < 0.0016) significant evidence for association between OH and the EBF1 locus (rs11953630, per-minor-allele odds ratio, 95 confidence interval: 0.90, 0.850.96; P=0.001), and nominal evidence (P < 0.05) for CYP17A1 (rs11191548: 0.85, 0.750.95; P=0.005), and NPR3-C5orf23 (rs1173771: 0.92, 0.870.98; P=0.009) loci. Among subjects not taking BP-lowering drugs, three SNPs within the NPPA/NPPB locus were nominally associated with increased risk of OH (rs17367504: 1.13, 1.021.24; P=0.02, rs198358: 1.10, 1.011.20; P=0.04, and rs5068: 1.22, 1.041.43; P=0.01). Moreover, an ADM variant was nominally associated with continuous orthostatic systolic BP response in the adjusted model (P=0.04). ConclusionThe overall association between common gene variants in BP loci and OH was generally weak and the direction of effect inconsistent with resting BP findings. These results suggest that OH and resting BP share few genetic components
BINGO: A code for the efficient computation of the scalar bi-spectrum
We present a new and accurate Fortran code, the BI-spectra and
Non-Gaussianity Operator (BINGO), for the efficient numerical computation of
the scalar bi-spectrum and the non-Gaussianity parameter f_{NL} in single field
inflationary models involving the canonical scalar field. The code can
calculate all the different contributions to the bi-spectrum and the parameter
f_{NL} for an arbitrary triangular configuration of the wavevectors. Focusing
firstly on the equilateral limit, we illustrate the accuracy of BINGO by
comparing the results from the code with the spectral dependence of the
bi-spectrum expected in power law inflation. Then, considering an arbitrary
triangular configuration, we contrast the numerical results with the analytical
expression available in the slow roll limit, for, say, the case of the
conventional quadratic potential. Considering a non-trivial scenario involving
deviations from slow roll, we compare the results from the code with the
analytical results that have recently been obtained in the case of the
Starobinsky model in the equilateral limit. As an immediate application, we
utilize BINGO to examine of the power of the non-Gaussianity parameter f_{NL}
to discriminate between various inflationary models that admit departures from
slow roll and lead to similar features in the scalar power spectrum. We close
with a summary and discussion on the implications of the results we obtain.Comment: v1: 5 pages, 5 figures; v2: 35 pages, 11 figures, title changed,
extensively revised; v3: 36 pages, 11 figures, to appear in JCAP. The BINGO
code is available online at
http://www.physics.iitm.ac.in/~sriram/bingo/bingo.htm
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