A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels

Haptoglobin is an acute phase inflammatory marker. Its main function is to bind hemoglobin released from erythrocytes to aid its elimination, and thereby haptoglobin prevents the generation of reactive oxygen species in the blood. Haptoglobin levels have been repeatedly associated with a variety of inflammation-linked infectious and non-infectious diseases, including malaria, tuberculosis, human immunodeficiency virus, hepatitis C, diabetes, carotid atherosclerosis, and acute myocardial infarction. However, a comprehensive genetic assessment of the inter-individual variability of circulating haptoglobin levels has not been conducted so far

Les parents connaissent-ils les fiches d'information contenues dans le carnet de santé ? ( Exemple de la fiche d'information sur la diarrhée aiguë de l'enfant)

LE KREMLIN-B.- PARIS 11-BU Méd (940432101) / SudocSudocFranceF

Manhattan plot of the GWAS of the discovery cohort comprising 631 children.

<p><b>A</b>, A Manhattan plot showing the −log₁₀(<i>P</i> values) of SNPs from the association analysis of the 631 SFS children from stage 1. <b>B</b>, An overview of the −log₁₀(<i>P</i> values) of Chromosome 16. <b>C</b>, The genomic region of the 618 LD block displayed in UCSC Genome Browser.</p

Estimates of familial correlations ± standard error for serum haptoglobin concentration (656 familles/2680 individuals).

<p>* <i>P</i>≤0.05, ** <i>P</i>≤0.01, *** <i>P</i>≤0.001: compared to zero.</p><p>Model 1 estimated all eight correlations without adjustment.</p><p>Model 2 estimated all eight correlations with adjustment for age and BMI,</p><p>Model 3 estimated three correlations with adjustment for age and BMI with no gender effect on parent or offspring correlations: FS = MS = MD = FD and SS = SD = DD.</p><p>Model 4 estimated three correlations with adjustment for age, BMI and rs2000999 allelic frequency with no gender effect on parent or offspring correlations: FS = MS = MD = FD and SS = SD = DD.</p><p>Values in brackets were constrained to be equal to a preceding value according to the hypotheses of the model.</p><p>BMI: body mass index.</p