Validación del Cuestionario de Salud General de Goldberg (versión 28 ítems) en consultas de Atención Primaria.

Se realiza un estudio para medir la validez del cuestionario GHQ-28 de Goldberg, comparándolo con la entrevista psiquiátrica estructurada PSE-ID, 9ª edición. Se expone el método utilizado en la selección de 150 pacientes de ambos sexos, todos provenientes de consultas de Atención Primaria, para la entrevista psiquiátrica de validación. Se analiza el cuestionario en tres órdenes: como test de "screening", como detector de morbilidad psiquiátrica real y como indicador de severidad clínica. Tras comparar los resultados con otros trabajos similares, se concluye con algunas recomendaciones para el uso del GHQ-28

Validación del Cuestionario de Salud General de Goldberg (versión 28 ítems) en consultas de Atención Primaria.

Se realiza un estudio para medir la validez del cuestionario GHQ-28 de Goldberg, comparándolo con la entrevista psiquiátrica estructurada PSE-ID, 9ª edición. Se expone el método utilizado en la selección de 150 pacientes de ambos sexos, todos provenientes de consultas de Atención Primaria, para la entrevista psiquiátrica de validación. Se analiza el cuestionario en tres órdenes: como test de "screening", como detector de morbilidad psiquiátrica real y como indicador de severidad clínica. Tras comparar los resultados con otros trabajos similares, se concluye con algunas recomendaciones para el uso del GHQ-28

Validación del Cuestionario de Salud General de Goldberg (versión 28 ítems) en consultas de Atención Primaria.

Se realiza un estudio para medir la validez del cuestionario GHQ-28 de Goldberg, comparándolo con la entrevista psiquiátrica estructurada PSE-ID, 9ª edición. Se expone el método utilizado en la selección de 150 pacientes de ambos sexos, todos provenientes de consultas de Atención Primaria, para la entrevista psiquiátrica de validación. Se analiza el cuestionario en tres órdenes: como test de "screening", como detector de morbilidad psiquiátrica real y como indicador de severidad clínica. Tras comparar los resultados con otros trabajos similares, se concluye con algunas recomendaciones para el uso del GHQ-28

Transcriptional portrait of M. bovis BCG during biofilm production shows genes differentially expressed during intercellular aggregation and substrate attachment.

Mycobacterium tuberculosis and M. smegmatis form drug-tolerant biofilms through dedicated genetic programs. In support of a stepwise process regulating biofilm production in mycobacteria, it was shown elsewhere that lsr2 participates in intercellular aggregation, while groEL1 was required for biofilm maturation in M. smegmatis. Here, by means of RNA-Seq, we monitored the early steps of biofilm production in M. bovis BCG, to distinguish intercellular aggregation from attachment to a surface. Genes encoding for the transcriptional regulators dosR and BCG0114 (Rv0081) were significantly regulated and responded differently to intercellular aggregation and surface attachment. Moreover, a M. tuberculosis H37Rv deletion mutant in the Rv3134c-dosS-dosR regulon, formed less biofilm than wild type M. tuberculosis, a phenotype reverted upon reintroduction of this operon into the mutant. Combining RT-qPCR with microbiological assays (colony and surface pellicle morphologies, biofilm quantification, Ziehl-Neelsen staining, growth curve and replication of planktonic cells), we found that BCG0642c affected biofilm production and replication of planktonic BCG, whereas ethR affected only phenotypes linked to planktonic cells despite its downregulation at the intercellular aggregation step. Our results provide evidence for a stage-dependent expression of genes that contribute to biofilm production in slow-growing mycobacteria

Possibilistic classifiers for numerical data

International audienceNaive Bayesian Classifiers, which rely on independence hypotheses, together with a normality assumption to estimate densities for numerical data, are known for their simplicity and their effectiveness. However, estimating densities, even under the normality assumption, may be problematic in case of poor data. In such a situation, possibility distributions may provide a more faithful representation of these data. Naive Possibilistic Classifiers (NPC), based on possibility theory, have been recently proposed as a counterpart of Bayesian classifiers to deal with classification tasks. There are only few works that treat possibilistic classification and most of existing NPC deal only with categorical attributes. This work focuses on the estimation of possibility distributions for continuous data. In this paper we investigate two kinds of possibilistic classifiers. The first one is derived from classical or flexible Bayesian classifiers by applying a probability–possibility transformation to Gaussian distributions, which introduces some further tolerance in the description of classes. The second one is based on a direct interpretation of data in possibilistic formats that exploit an idea of proximity between data values in different ways, which provides a less constrained representation of them. We show that possibilistic classifiers have a better capability to detect new instances for which the classification is ambiguous than Bayesian classifiers, where probabilities may be poorly estimated and illusorily precise. Moreover, we propose, in this case, an hybrid possibilistic classification approach based on a nearest-neighbour heuristics to improve the accuracy of the proposed possibilistic classifiers when the available information is insufficient to choose between classes. Possibilistic classifiers are compared with classical or flexible Bayesian classifiers on a collection of benchmarks databases. The experiments reported show the interest of possibilistic classifiers. In particular, flexible possibilistic classifiers perform well for data agreeing with the normality assumption, while proximity-based possibilistic classifiers outperform others in the other cases. The hybrid possibilistic classification exhibits a good ability for improving accuracy

New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis

Anti-tumor necrosis factor (anti-TNF) drugs are effective against psoriasis, although 20–30% of patients are nonresponders. Few pharmacogenomic studies have been performed to predict the response to anti-TNF drugs in psoriasis. We studied 173 polymorphisms to establish an association with the response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis (N=144). We evaluated the response using PASI75 at 3, 6 and 12 months. The results of the multivariate analysis showed an association between polymorphisms in PGLYR4, ZNF816A, CTNNA2, IL12B, MAP3K1 and HLA-C genes and the response at 3 months. Besides, the results for polymorphisms in IL12B and MAP3K1 were replicated at 6 months. We also obtained significant results for IL12B polymorphism at 1 year. Moreover, polymorphisms in FCGR2A, HTR2A and CDKAL1 were significant at 6 months. This is the first study to show an association with these polymorphisms. However, these biomarkers should be validated in large-scale studies before implementation in clinical practiceThis study was supported by Instituto de Salud Carlos III (FIS PI10/01740), Fundación Teófilo Hernando, and AbbVie. RPP has a grant from Universidad Autónoma de Madrid (FPI program 2013

The inventory of geological heritage of the state of São Paulo, Brazil: Methodological basis, results and perspectives

An inventory of geological sites based on solid and clear criteria is a first step for any geoconservation strategy. This paper describes the method used in the geoheritage inventory of the State of São Paulo, Brazil, and presents its main results. This inventory developed by the geoscientific community aimed to identify geosites with scientific value in the whole state, using a systematic approach. All 142 geosites representative of 11 geological frameworks were characterised and quantitatively evaluated according to their scientific value and risk of degradation, in order to establish priorities for their future management. An online database of the inventory is under construction, which will be available to be easily consulted and updated by the geoscientific community. All data were made available to the State Geological Institute as the backbone for the implementation of a future state geoconservation strategy.The authors acknowledge the Science Without Borders Programme, Process 075/2012, which supported this study and the São Paulo Research Foundation (FAPESP), Process 2011/17261-6. We also thanks C. Mazoca for his help with maps and figures.info:eu-repo/semantics/acceptedVersio

The Zoning of Semi-Enclosed Bodies of Water According to the Sediment Pollution: The Bay of Algeciras as a Case Example

This paper reports a study of the occurrence and levels of polycyclic aromatic hydrocarbons (PAHs) in a bay characterised by a chronic persistent impact. A total of 55 sediment samples were taken at different depths up to 111 m in two sampling campaigns. Chemical analyses were carried out by gas chromatography-mass spectroscopy. The results indicate that: (1) significant spatial variations exist, (2) levels of PAHs are related more strongly to the spatial distribution of sediments than to mineralogy/granulometry, (3) the sediments are slightly-to-moderately contaminated by PAHs, and (4) these PAHs derive from pyrolytic and petrogenic sources. Through use of an innovative data classification system (proposed according to depth and spatial location of sampling points), and using factorial and cluster techniques, five zones have been differentiated depending on the contamination level and source

Coarse graining ππ scattering

We carry out an analysis of ππ scattering in the I J = 00, 11 and 20 channels in configuration space up to a maximal center-of-mass energy √ s = 1.4 GeV. We separate the interaction into two regions marked by an elementarity radius of the system; namely, a long distance region above which pions can be assumed to interact as elementary particles and a short distance region where many physical effects cannot be disentangled. The long distance interaction is described by chiral dynamics, where a two-pionexchange potential is identified, computed and compared to lattice calculations. The short distance piece corresponds to a coarse grained description exemplified by a superposition of delta-shell potentials sampling the interaction with the minimal wavelength. We show how the so constructed nonperturbative scattering amplitude complies with the proper analytic structure, allowing for an explicit N/D type decomposition in terms of the corresponding Jost functions and fulfilling dispersion relations without subtractions. We also address renormalization issues in coordinate space and investigate the role of crossing when fitting the scattering amplitudes above and below threshold to Roy-equation results. At higher energies, we show how inelasticities can be described by one single complex and energy dependent parameter. A successful description of the data can be achieved with a minimal number of fitting parameters, suggesting that coarse graining is a viable approach to analyze hadronic processes.Work partially supported by Spanish MINEICO and European FEDER funds (grants FIS2014-59386-P, FIS2017-85053-C2-1-P and FPA2015- 64041-C2-1-P), Junta de Andalucía (grant FQM-225) and the Swiss National Science Foundation