A State-of-the-Science Review of Arsenic's Effects on Glucose Homeostasis in Experimental Models.

BackgroundThe prevalence of type 2 diabetes (T2D) has more than doubled since 1980. Poor nutrition, sedentary lifestyle, and obesity are among the primary risk factors. While an estimated 70% of cases are attributed to excess adiposity, there is an increased interest in understanding the contribution of environmental agents to diabetes causation and severity. Arsenic is one of these environmental chemicals, with multiple epidemiology studies supporting its association with T2D. Despite extensive research, the molecular mechanism by which arsenic exerts its diabetogenic effects remains unclear.ObjectivesWe conducted a literature search focused on arsenite exposure in vivo and in vitro, using relevant end points to elucidate potential mechanisms of oral arsenic exposure and diabetes development.MethodsWe explored experimental results for potential mechanisms and elucidated the distinct effects that occur at high vs. low exposure. We also performed network analyses relying on publicly available data, which supported our key findings.ResultsWhile several mechanisms may be involved, our findings support that arsenite has effects on whole-body glucose homeostasis, insulin-stimulated glucose uptake, glucose-stimulated insulin secretion, hepatic glucose metabolism, and both adipose and pancreatic β-cell dysfunction.DiscussionThis review applies state-of-the-science approaches to identify the current knowledge gaps in our understanding of arsenite on diabetes development. https://doi.org/10.1289/EHP4517

An operator expansion method for computing nonlinear surface waves on a ferrofluid jet

We present a new numerical method to simulate the time evolution of axisym- metric nonlinear waves on the surface of a ferrofluid jet. It is based on the reduction of this problem to a lower-dimensional computation involving surface variables alone. To do so, we describe the associated Dirichlet–Neumann op- erator in terms of a Taylor series expansion where each term can be efficiently computed by a pseudo-spectral scheme using the fast Fourier transform. We show detailed numerical tests on the convergence of this operator and, to illus- trate the performance of our method, we simulate the long-time propagation and pairwise collisions of axisymmetric solitary waves. Both depression and elevation waves are examined by varying the magnetic field. Comparisons with weakly nonlinear predictions are also provided

UK views towards breastfeeding in public: an analysis of the public's response to the Claridge’s incident

Background: The embarrassment UK mothers experience when breastfeeding in public has often been cited as a key factor in the decision of the mother to discontinue breastfeeding. There is convincing evidence that many UK residents are not comfortable with women breastfeeding in public; however, little is known about the underlying reasons for this discomfort. Objective: To assess views on breastfeeding in public in the United Kingdom and to understand why some UK residents object to this practice. Methods: The comment sections of news media websites and parenting forums were systematically identified and reviewed for statements made in response to an incident widely reported in the British press: a woman was asked to cover up while breastfeeding in public at Claridge’s, a London luxury hotel. Of these, 805 comments (73,108 words) met the inclusion criteria and were thematically analyzed. Results: The majority of commenters were supportive of “discreet” breastfeeding in public, but a significant portion felt that breastfeeding in public is always inappropriate. Sexualization of the breast was mainly evoked as something others may experience while viewing a breastfeeding mother, rather than to reflect the commenters' own views. Common justifications cited against breastfeeding in public were onlookers’ embarrassment (not knowing where to look) and disgust (at bodily fluids and/or functions). Conclusion: Campaigns portraying breastfeeding in public as normal and desirable with a focus on human milk as food rather than a bodily fluid may improve societal acceptance of breastfeeding in public. Keywords: Breastfeeding; public

ECONOMIC IMPACTS RESULTING FROM CO-FIRING BIOMASS FEEDSTOCKS IN SOUTHEASTERN UNITED STATES COAL-FIRED PLANTS

Economic impacts of using biomass in Southeast United States coal-fired plants are estimated using a county-level biomass database; ORCED, a dynamic electricity distribution model that estimates feedstock value; ORIBAS, a GIS model that estimates feedstock transportation costs; and IMPLAN, an input-output model that determines the impacts of co-firing on economic activity.Resource /Energy Economics and Policy,

The diastereoselective Meth-Cohn epoxidation of camphor-derived vinyl sulfones

Some camphor-derived vinyl sulfones bearing oxygen functionality at the allylic position have been synthesized and their nucleophilic epoxidation reactions under Meth-Cohn conditions have been explored. The γ-oxygenated camphor-derived vinyl sulfones underwent mildly diastereoselective nucleophilic epoxidation reactions, affording the derived sulfonyloxiranes in up to 5.8:1 dr. The observed diastereoselectivities were sensitive to the reaction conditions employed. In contrast, no stereoselectivity was observed in the nucleophilic epoxidation of the corresponding γ-oxygenated isobornyl vinyl sulfone. A tentative mechanism has been proposed to explain the origins of the diastereoselectivit

Putting the genome on the map

The maps of our everyday lives are much more than just linear lists of place names. Instead, their colours, symbols, contours and grid lines seek to describe different types of landscape, and to depict the spatial relationships between structural and functional landmarks of the environment (Fig. 1). It was the combination of photography and aviation that revolutionized mapmaking in the early part of this century. In much the same way, it is fluorescence microscopy and digital imaging (Box 1) in combination with molecular genetics that is driving our emerging view of the genome in space and time