232 research outputs found
Pursuing futures through children: crisis, social reproduction, and transformation in Burundiâs transnational families
Based on multisited fieldwork in Kigali, Rwanda, Belgium, and the Netherlands following the political crisis in Burundi in 2015, we explore decisions and plans for the future among Burundians in exile. In this way, we contribute to research about future making and social reproduction in families in a transnational social field affected by crisis. Adding to the literature, we show the specific effects of crisis on transnational familiesâ practices and aspirations, such as parental efforts to prevent traumatic world views and the constant need for families to readjust their plans to ongoing crisis dynamics. We argue that as the violence has disrupted the migrant parentsâ hopes for a better future for themselves, they redirect their efforts towards their childrenâs futures. We thus argue that not only future making practices but also aspirations should be seen as social and relational, particularly in times of crisis. In particular, the Burundians living in Rwanda, Belgium and the Netherlands seek to provide their offspring with the skills to become educated, social and moral beings, even it entails sacrificing their own lives and aspirations. Moreover, adding to debates on migrantsâ efforts to reproduce their own cultural values and practices in host societies, we find that the Burundian parents attempt to change what they perceive as a âculture of hatred and vengeanceâ with parenting practices. As such, we argue that many migrant parents explicitly pursue social transformation through their children.ASC â Publicaties niet-programma gebonde
Finite-temperature scalar fields and the cosmological constant in an Einstein universe
We study the back reaction effect of massless minimally coupled scalar field
at finite temperatures in the background of Einstein universe. Substituting for
the vacuum expectation value of the components of the energy-momentum tensor on
the RHS of the Einstein equation, we deduce a relationship between the radius
of the universe and its temperature. This relationship exhibit a maximum
temperature, below the Planck scale, at which the system changes its behaviour
drastically. The results are compared with the case of a conformally coupled
field. An investigation into the values of the cosmological constant exhibit a
remarkable difference between the conformally coupled case and the minimally
coupled one.Comment: 7 pages, 2 figure
Quintessence and Gravitational Waves
We investigate some aspects of quintessence models with a non-minimally
coupled scalar field and in particular we show that it can behave as a
component of matter with . We study the
properties of gravitational waves in this class of models and discuss their
energy spectrum and the cosmic microwave background anisotropies they induce.
We also show that gravitational waves are damped by the anisotropic stress of
the radiation and that their energy spectrum may help to distinguish between
inverse power law potential and supergravity motivated potential. We finish by
a discussion on the constraints arising from their density parameter
\Omega_\GW.Comment: 21 pages, 18 figures, fianl version, accepted for publication in PR
Applications of scalar attractor solutions to Cosmology
We develop a framework to study the phase space of a system consisting of a
scalar field rolling down an arbitrary potential with varying slope and a
background fluid, in a cosmological setting. We give analytical approximate
solutions of the field evolution and discuss applications of its features to
the issues of quintessence, moduli stabilisation and quintessential inflation.Comment: 9 pages, 7 figures. Accepted for publication in PR
Controversies and priorities in amyotrophic lateral sclerosis
Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS) cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial proportion of the remainder of cases of familial ALS have now been traced to an expansion of the intronic hexanucleotide repeat sequence in C9orf72. This breakthrough provides an opportunity to re-evaluate longstanding concepts regarding the cause and natural history of ALS, coming soon after the pathological unification of ALS with frontotemporal dementia through a shared pathological signature of cytoplasmic inclusions of the ubiquitinated protein TDP-43. However, with profound clinical, prognostic, neuropathological, and now genetic heterogeneity, the concept of ALS as one disease appears increasingly untenable. This background calls for the development of a more sophisticated taxonomy, and an appreciation of ALS as the breakdown of a wider network rather than a discrete vulnerable population of specialised motor neurons. Identification of C9orf72 repeat expansions in patients without a family history of ALS challenges the traditional division between familial and sporadic disease. By contrast, the 90% of apparently sporadic cases and incomplete penetrance of several genes linked to familial cases suggest that at least some forms of ALS arise from the interplay of multiple genes, poorly understood developmental, environmental, and age-related factors, as well as stochastic events
Can forest management based on natural disturbances maintain ecological resilience?
Given the increasingly global stresses on forests, many ecologists argue that managers must maintain ecological resilience: the capacity of ecosystems to absorb disturbances without undergoing fundamental change. In this review we ask: Can the emerging paradigm of natural-disturbance-based management (NDBM) maintain ecological resilience in managed forests? Applying resilience theory requires careful articulation of the ecosystem state under consideration, the disturbances and stresses that affect the persistence of possible alternative states, and the spatial and temporal scales of management relevance. Implementing NDBM while maintaining resilience means recognizing that (i) biodiversity is important for long-term ecosystem persistence, (ii) natural disturbances play a critical role as a generator of structural and compositional heterogeneity at multiple scales, and (iii) traditional management tends to produce forests more homogeneous than those disturbed naturally and increases the likelihood of unexpected catastrophic change by constraining variation of key environmental processes. NDBM may maintain resilience if silvicultural strategies retain the structures and processes that perpetuate desired states while reducing those that enhance resilience of undesirable states. Such strategies require an understanding of harvesting impacts on slow ecosystem processes, such as seed-bank or nutrient dynamics, which in the long term can lead to ecological surprises by altering the forest's capacity to reorganize after disturbance
On exact solutions for quintessential (inflationary) cosmological models with exponential potentials
We first study dark energy models with a minimally-coupled scalar field and
exponential potentials, admitting exact solutions for the cosmological
equations: actually, it turns out that for this class of potentials the
Einstein field equations exhibit alternative Lagrangians, and are completely
integrable and separable (i.e. it is possible to integrate the system
analytically, at least by quadratures). We analyze such solutions, especially
discussing when they are compatible with a late time quintessential expansion
of the universe. As a further issue, we discuss how such quintessential scalar
fields can be connected to the inflationary phase, building up, for this class
of potentials, a quintessential inflationary scenario: actually, it turns out
that the transition from inflation toward late-time exponential quintessential
tail admits a kination period, which is an indispensable ingredient of this
kind of theoretical models. All such considerations have also been done by
including radiation into the model.Comment: Revtex4, 10 figure
Magnetogenesis and the dynamics of internal dimensions
The dynamical evolution of internal space-like dimensions breaks the
invariance of the Maxwell's equations under Weyl rescaling of the (conformally
flat) four-dimensional metric. Depending upon the number and upon the dynamics
of internal dimensions large scale magnetic fields can be created. The
requirements coming from magnetogenesis together with the other cosmological
constraints are examined under the assumption that the internal dimensions
either grow or shrink (in conformal time) prior to a radiation dominated epoch.
If the internal dimensions are growing the magnitude of the generated magnetic
fields can seed the galactic dynamo mechanism.Comment: 27 in RevTex style, four figure
Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1
Background
Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with a genetic contribution to disease liability. Genome-wide association studies (GWAS) have identified ten risk loci to date, including the TNIP1/GPX3 locus on chromosome five. Given association analysis data alone cannot determine the most plausible risk gene for this locus, we undertook a comprehensive suite of in silico, in vivo and in vitro studies to address this.
Methods
The Functional Mapping and Annotation (FUMA) pipeline and five tools (conditional and joint analysis (GCTA-COJO), Stratified Linkage Disequilibrium Score Regression (S-LDSC), Polygenic Priority Scoring (PoPS), Summary-based Mendelian Randomisation (SMR-HEIDI) and transcriptome-wide association study (TWAS) analyses) were used to perform bioinformatic integration of GWAS data (Ncases = 20,806, Ncontrols = 59,804) with âomics reference datasets including the blood (eQTLgen consortium N = 31,684) and brain (N = 2581). This was followed up by specific expression studies in ALS case-control cohorts (microarray Ntotal = 942, protein Ntotal = 300) and gene knockdown (KD) studies of human neuronal iPSC cells and zebrafish-morpholinos (MO).
Results
SMR analyses implicated both TNIP1 and GPX3 (p < 1.15 Ă 10â6), but there was no simple SNP/expression relationship. Integrating multiple datasets using PoPS supported GPX3 but not TNIP1. In vivo expression analyses from blood in ALS cases identified that lower GPX3 expression correlated with a more progressed disease (ALS functional rating score, p = 5.5 Ă 10â3, adjusted R2 = 0.042, Beffect = 27.4 ± 13.3âng/ml/ALSFRS unit) with microarray and protein data suggesting lower expression with risk allele (recessive model p = 0.06, p = 0.02 respectively). Validation in vivo indicated gpx3 KD caused significant motor deficits in zebrafish-MO (mean difference vs. control ± 95% CI, vs. control, swim distance = 112 ± 28âmm, time = 1.29 ± 0.59 s, speed = 32.0 ± 2.53âmm/s, respectively, p for all <â0.0001), which were rescued with gpx3 expression, with no phenotype identified with tnip1 KD or gpx3 overexpression.
Conclusions
These results support GPX3 as a lead ALS risk gene in this locus, with more data needed to confirm/reject a role for TNIP1. This has implications for understanding disease mechanisms (GPX3 acts in the same pathway as SOD1, a well-established ALS-associated gene) and identifying new therapeutic approaches. Few previous examples of in-depth investigations of risk loci in ALS exist and a similar approach could be applied to investigate future expected GWAS findings
Categorizing Different Approaches to the Cosmological Constant Problem
We have found that proposals addressing the old cosmological constant problem
come in various categories. The aim of this paper is to identify as many
different, credible mechanisms as possible and to provide them with a code for
future reference. We find that they all can be classified into five different
schemes of which we indicate the advantages and drawbacks.
Besides, we add a new approach based on a symmetry principle mapping real to
imaginary spacetime.Comment: updated version, accepted for publicatio
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