441 research outputs found
Prospects for asteroseismology
The observational basis for asteroseismology is being dramatically
strengthened, through more than two years of data from the CoRoT satellite, the
flood of data coming from the Kepler mission and, in the slightly longer term,
from dedicated ground-based facilities. Our ability to utilize these data
depends on further development of techniques for basic data analysis, as well
as on an improved understanding of the relation between the observed
frequencies and the underlying properties of the stars. Also, stellar modelling
must be further developed, to match the increasing diagnostic potential of the
data. Here we discuss some aspects of data interpretation and modelling,
focussing on the important case of stars with solar-like oscillations.Comment: Proc. HELAS Workshop on 'Synergies between solar and stellar
modelling', eds M. Marconi, D. Cardini & M. P. Di Mauro, Astrophys. Space
Sci., in the press Revision: correcting abscissa labels on Figs 1 and
Noise Kernel and Stress Energy Bi-Tensor of Quantum Fields in Hot Flat Space and Gaussian Approximation in the Optical Schwarzschild Metric
Continuing our investigation of the regularization of the noise kernel in
curved spacetimes [N. G. Phillips and B. L. Hu, Phys. Rev. D {\bf 63}, 104001
(2001)] we adopt the modified point separation scheme for the class of optical
spacetimes using the Gaussian approximation for the Green functions a la
Bekenstein-Parker-Page. In the first example we derive the regularized noise
kernel for a thermal field in flat space. It is useful for black hole
nucleation considerations. In the second example of an optical Schwarzschild
spacetime we obtain a finite expression for the noise kernel at the horizon and
recover the hot flat space result at infinity. Knowledge of the noise kernel is
essential for studying issues related to black hole horizon fluctuations and
Hawking radiation backreaction. We show that the Gaussian approximated Green
function which works surprisingly well for the stress tensor at the
Schwarzschild horizon produces significant error in the noise kernel there. We
identify the failure as occurring at the fourth covariant derivative order.Comment: 21 pages, RevTeX
Recent Advances in Modeling Stellar Interiors
Advances in stellar interior modeling are being driven by new data from
large-scale surveys and high-precision photometric and spectroscopic
observations. Here we focus on single stars in normal evolutionary phases; we
will not discuss the many advances in modeling star formation, interacting
binaries, supernovae, or neutron stars. We review briefly: 1) updates to input
physics of stellar models; 2) progress in two and three-dimensional evolution
and hydrodynamic models; 3) insights from oscillation data used to infer
stellar interior structure and validate model predictions (asteroseismology).
We close by highlighting a few outstanding problems, e.g., the driving
mechanisms for hybrid gamma Dor/delta Sct star pulsations, the cause of giant
eruptions seen in luminous blue variables such as eta Car and P Cyg, and the
solar abundance problem.Comment: Proceedings for invited talk at conference High Energy Density
Laboratory Astrophysics 2010, Caltech, March 2010, submitted for special
issue of Astrophysics and Space Science; 7 pages; 5 figure
Energy-Momentum Tensor of Particles Created in an Expanding Universe
We present a general formulation of the time-dependent initial value problem
for a quantum scalar field of arbitrary mass and curvature coupling in a FRW
cosmological model. We introduce an adiabatic number basis which has the virtue
that the divergent parts of the quantum expectation value of the
energy-momentum tensor are isolated in the vacuum piece of , and
may be removed using adiabatic subtraction. The resulting renormalized
is conserved, independent of the cutoff, and has a physically transparent,
quasiclassical form in terms of the average number of created adiabatic
`particles'. By analyzing the evolution of the adiabatic particle number in de
Sitter spacetime we exhibit the time structure of the particle creation
process, which can be understood in terms of the time at which different
momentum scales enter the horizon. A numerical scheme to compute as a
function of time with arbitrary adiabatic initial states (not necessarily de
Sitter invariant) is described. For minimally coupled, massless fields, at late
times the renormalized goes asymptotically to the de Sitter invariant
state previously found by Allen and Folacci, and not to the zero mass limit of
the Bunch-Davies vacuum. If the mass m and the curvature coupling xi differ
from zero, but satisfy m^2+xi R=0, the energy density and pressure of the
scalar field grow linearly in cosmic time demonstrating that, at least in this
case, backreaction effects become significant and cannot be neglected in de
Sitter spacetime.Comment: 28 pages, Revtex, 11 embedded .ps figure
Thermal and photochemical control of nitro-nitrito linkage isomerism in single-crystals of [Ni(medpt)(NO<sub>2</sub>)(η<sup>2</sup>-ONO)]
The known complex [Ni(medpt)(η1-NO2)(η2-ONO)] 1 (medpt = 3,3âČ-diamino-N-methyldipropylamine) crystallises in the monoclinic space group P21/m with 1.5 molecules in the asymmetric unit with two different η1-NO2 ligand environments in the crystal structure. At 298 K the molecule (A) sitting in a general crystallographic site displays a mixture of isomers, 78% of the η1-NO2 isomer and 22% of an endo-nitritoâ(η1-ONO) form. The molecule (B) sitting on a crystallographic mirror plane adopts the η1-NO2 isomeric form exclusively. However, a variable temperature crystallographic study showed that the two isomers were in equilibrium and upon cooling to 150 K the η1-ONO isomer converted completely to the η1-NO2 isomer, so that both independent molecules in the asymmetric unit were 100% in the η1-NO2 form. A kinetic analysis of the equilibrium afforded values of ÎH = â9.6 (±0.4) kJ molâ1, ÎS = â21.5 (±1.8) J Kâ1 molâ1 and EA = â1.6 (±0.05) kJ molâ1. Photoirradiation of single crystals of 1 with 400 nm light, at 100 K, resulted in partial isomerisation of the η1-NO2 isomer to the metastable η1-ONO isomer, with 89% for molecule (A), and 32% for molecule (B). The crystallographic space group also reduced in symmetry to P21 with ZâČ = 3. The metastable state existed up to a temperature of 150 K above which temperature it reverted to the ground state. An analysis of the crystal packing in the ground and metastable states suggests that hydrogen bonding is responsible for the difference in the conversion between molecules (A) and (B)
Development and validation of an electronic health records-based opioid use disorder algorithm by expert clinical adjudication among patients with prescribed opioids
Background: In the US, over 200 lives are lost from opioid overdoses each day. Accurate and prompt diagnosis of opioid use disorders (OUD) may help prevent overdose deaths. However, international classification of disease (ICD) codes for OUD are known to underestimate prevalence, and their specificity and sensitivity are unknown. We developed and validated algorithms to identify OUD in electronic health records (EHR) and examined the validity of OUD ICD codes. Methods: Through four iterations, we developed EHR-based OUD identification algorithms among patients who were prescribed opioids from 2014 to 2017. The algorithms and OUD ICD codes were validated against 169 independent âgold standardâ EHR chart reviews conducted by an expert adjudication panel across four healthcare systems. After using 2014â2020 EHR for validating iteration 1, the experts were advised to use 2014â2017 EHR thereafter. Results: Of the 169 EHR charts, 81 (48%) were reviewed by more than one expert and exhibited 85% expert agreement. The experts identified 54 OUD cases. The experts endorsed all 11 OUD criteria from the Diagnostic and Statistical Manual of Mental Disorders-5, including craving (72%), tolerance (65%), withdrawal (56%), and recurrent use in physically hazardous conditions (50%). The OUD ICD codes had 10% sensitivity and 99% specificity, underscoring large underestimation. In comparison our algorithm identified OUD with 23% sensitivity and 98% specificity. Conclusions and relevance: This is the first study to estimate the validity of OUD ICD codes and develop validated EHR-based OUD identification algorithms. This work will inform future research on early intervention and prevention of OUD
Features that best define the heterogeneity and homogeneity of autism in preschool-age children: A multisite caseâcontrol analysis replicated across two independent samples
The heterogeneous nature of children with symptoms of autism spectrum disorder (ASD) makes it difficult to identify risk factors and effective treatment options. We sought to identify behavioral and developmental features that best define the heterogeneity and homogeneity in 2â5-year-old children classified with ASD and subthreshold ASD characteristics. Children were enrolled in a multisite caseâcontrol study of ASD. Detailed behavioral and developmental data were gathered by maternal telephone interview, parent-administered questionnaires, child cognitive evaluation, and ASD diagnostic measures. Participants with a positive ASD screen score or prior ASD diagnosis were referred for comprehensive evaluation. Children in the ASD group met study criteria based on this evaluation; children who did not meet study criteria were categorized as having subthreshold ASD characteristics. There were 1480 children classified as ASD (81.6% boys) and 594 children classified as having subthreshold ASD characteristics (70.2% boys) in the sample. Factors associated with dysregulation (e.g., aggression, anxiety/depression, sleep problems) followed by developmental abilities (e.g., expressive and receptive language skills) most contributed to heterogeneity in both groups of children. Atypical sensory response contributed to homogeneity in children classified as ASD but not those with subthreshold characteristics. These findings suggest that dysregulation and developmental abilities are clinical features that can impact functioning in children with ASD and other DD, and that documenting these features in pediatric records may help meet the needs of the individual child. Sensory dysfunction could be considered a core feature of ASD and thus used to inform more targeted screening, evaluation, treatment, and research efforts. Lay summary: The diverse nature of autism spectrum disorder (ASD) makes it difficult to find risk factors and treatment options. We identified the most dissimilar and most similar symptom(s) in children classified as ASD and as having subthreshold ASD characteristics. Factors associated with dysregulation and developmental abilities contributed to diversity in both groups of children. Sensory dysfunction was the most common symptom in children with ASD but not those with subthreshold characteristics. Findings can inform clinical practice and research
Modeling the Subsurface Structure of Sunspots
While sunspots are easily observed at the solar surface, determining their
subsurface structure is not trivial. There are two main hypotheses for the
subsurface structure of sunspots: the monolithic model and the cluster model.
Local helioseismology is the only means by which we can investigate
subphotospheric structure. However, as current linear inversion techniques do
not yet allow helioseismology to probe the internal structure with sufficient
confidence to distinguish between the monolith and cluster models, the
development of physically realistic sunspot models are a priority for
helioseismologists. This is because they are not only important indicators of
the variety of physical effects that may influence helioseismic inferences in
active regions, but they also enable detailed assessments of the validity of
helioseismic interpretations through numerical forward modeling. In this paper,
we provide a critical review of the existing sunspot models and an overview of
numerical methods employed to model wave propagation through model sunspots. We
then carry out an helioseismic analysis of the sunspot in Active Region 9787
and address the serious inconsistencies uncovered by
\citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find
that this sunspot is most probably associated with a shallow, positive
wave-speed perturbation (unlike the traditional two-layer model) and that
travel-time measurements are consistent with a horizontal outflow in the
surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic
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