318 research outputs found
Differential Expression Of Gap Junction mRNAs And Proteins In The Developing Murine Kidney And In Experimentally Induced Nephric Mesenchymes
The expression of three gap junction (GJ) proteins, alpha-1 (Cx43), beta-1 (Cx32), and beta-2 (Cx26), and their transcripts were examined during the ontogeny of the mouse and rat kidney. These proteins were expressed in two non-overlapping patterns. The alpha-1 GJ protein was first observed in mesenchymal cells in the 12-day mouse kidney. By day 14 and thereafter, the ai protein was detected in the transient S-shaped bodies, but not in the podocytes of the maturing glomeruli. After birth the antigen was retained in a small subset of secretory tubules.The beta-1 and beta-2 GJ proteins were similar in their developmental patterns. They were first detected in a small subset of secretory tubules in the subcortical zone of day 17 embryos. These tubules were identified by immunohistochemical markers to be proximal. At birth, practically all proximal tubules expressed the two antigens.This analysis of GJ proteins was consistent with the results of S1 nuclease protection assays showing that, while the alpha-1 mRNA appeared early during kidney development and declined around birth, the two beta mRNAs appeared later and became intensified during the last days of intrauterine development.In experimentally induced metanephric mesenchymes, a transient expression of the alpha-1 GJ protein was seen during the segregation of the tubular anlagen. beta-1 and beta-2 GJ proteins were not detected in such induced mesenchymes cultivated up to 7 days.These observations provide evidence for the cell-specific utilization of different GJ genes during different stages of kidney organogenesis. The alpha-1 gene is activated during the early segregation of the secretory tubule and might contribute to its compartmentalization, while the beta-1 and beta-2 gene products are not detected until advanced stages of development. The latter gene products might be correlated with the physiological activity of the proximal tubules in vivo, as they are not expressed in experimentally induced tubules detectable with markers for proximal tubules
The Contribution of the Light Quark Condensate to the Pion-Nucleon Sigma Term
There has been a discrepancy between values of the pion-nucleon sigma term
extracted by two different methods for many years. Analysis of recent high
precision pion-nucleon data has widened the gap between the two determinations.
It is argued that the two extractions correspond to different quantities and
that the difference between them can be understood and calculated.Comment: Modern Physics Letters A (in press
Scalar form-factor of the proton with light-cone QCD sum rules
In this article, we calculate the scalar form-factor of the proton in the
framework of the light-cone QCD sum rules approach with the three valence quark
light-cone distribution amplitudes up to twist-6, and observe the scalar
form-factor at intermediate and large momentum transfers has significant contributions from the end-point (or soft) terms. The
numerical values for the are compatible with the calculations
from the chiral quark model and lattice QCD at the region .Comment: 18 pages, 7 figures, revised versio
On the estimate of the sigma^(I = 1)_(KN)(0)-term value from the energy level shift of kaonic hydrogen in the ground state
Using the experimental data on the energy level shift of kaonic hydrogen in
the ground state (the DEAR Collaboration, Phys. Rev. Lett. 94, 212302 (2005))
and the theoretical value of the energy level shift, calculated within the
phenomenological quantum field theoretic approach to the description of strong
low-energy anti-K N and anti-K NN interactions developed at Stefan Meyer
Institut fuer subatomare Physik in Vienna, we estimate the value of the
sigma^(I = 1)_(KN)(0)-term of low-energy anti-K N scattering. We get sigma^(I =
1)_(KN)(0) = (433 +/- 85) MeV. This testifies the absence of strange quarks in
the proton structure.Comment: 7 pages, no figure
Another look at the BL Lacertae flux and spectral variability
The GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope
(WEBT) monitored BL Lacertae in 2008-2009 at radio, near-IR, and optical
frequencies. During this period, high-energy observations were performed by
XMM-Newton, Swift, and Fermi. We analyse these data with particular attention
to the calibration of Swift UV data, and apply a helical jet model to interpret
the source broad-band variability. The GASP-WEBT observations show an optical
flare in 2008 February-March, and oscillations of several tenths of mag on a
few-day time scale afterwards. The radio flux is only mildly variable. The UV
data from both XMM-Newton and Swift seem to confirm a UV excess that is likely
caused by thermal emission from the accretion disc. The X-ray data from
XMM-Newton indicate a strongly concave spectrum, as well as moderate flux
variability on an hour time scale. The Swift X-ray data reveal fast (interday)
flux changes, not correlated with those observed at lower energies. We compare
the spectral energy distribution (SED) corresponding to the 2008 low-brightness
state, which was characterised by a synchrotron dominance, to the 1997 outburst
state, where the inverse-Compton emission was prevailing. A fit with an
inhomogeneous helical jet model suggests that two synchrotron components are at
work with their self inverse-Compton emission. Most likely, they represent the
radiation from two distinct emitting regions in the jet. We show that the
difference between the source SEDs in 2008 and 1997 can be explained in terms
of pure geometrical variations. The outburst state occurred when the
jet-emitting regions were better aligned with the line of sight, producing an
increase of the Doppler beaming factor. Our analysis demonstrates that the jet
geometry can play an extremely important role in the BL Lacertae flux and
spectral variability.Comment: 12 pages, 10 figures, accepted for publication in A&
How do the information needs of cancer patients differ at different stages of the cancer journey? A cross-sectional survey
Renormalization of relativistic baryon chiral perturbation theory and power counting
We discuss a renormalization scheme for relativistic baryon chiral
perturbation theory which provides a simple and consistent power counting for
renormalized diagrams. The method involves finite subtractions of dimensionally
regularized diagrams beyond the standard scheme of chiral
perturbation theory to remove contributions violating the power counting. This
is achieved by a suitable renormalization of the parameters of the most general
effective Lagrangian. In addition to simplicity our method has the benefit that
it can be easily applied to multiloop diagrams. As an application we discuss
the mass and the scalar form factor of the nucleon and compare the results with
the expressions of the infrared regularization of Becher and Leutwyler.Comment: 20 pages, RevTex, 1 figure, published version is shortene
Precision Pion-Proton Elastic Differential Cross Sections at Energies Spanning the Delta Resonance
A precision measurement of absolute pi+p and pi-p elastic differential cross
sections at incident pion laboratory kinetic energies from T_pi= 141.15 to
267.3 MeV is described. Data were obtained detecting the scattered pion and
recoil proton in coincidence at 12 laboratory pion angles from 55 to 155
degrees for pi+p, and six angles from 60 to 155 degrees for pi-p. Single arm
measurements were also obtained for pi+p energies up to 218.1 MeV, with the
scattered pi+ detected at six angles from 20 to 70 degrees. A flat-walled,
super-cooled liquid hydrogen target as well as solid CH2 targets were used. The
data are characterized by small uncertainties, ~1-2% statistical and ~1-1.5%
normalization. The reliability of the cross section results was ensured by
carrying out the measurements under a variety of experimental conditions to
identify and quantify the sources of instrumental uncertainty. Our lowest and
highest energy data are consistent with overlapping results from TRIUMF and
LAMPF. In general, the Virginia Polytechnic Institute SM95 partial wave
analysis solution describes our data well, but the older Karlsruhe-Helsinki PWA
solution KH80 does not.Comment: 39 pages, 22 figures (some with quality reduced to satisfy ArXiv
requirements. Contact M.M. Pavan for originals). Submitted to Physical Review
Determination of the pion-nucleon coupling constant and scattering lengths
We critically evaluate the isovector GMO sum rule for forward pion-nucleon
scattering using the recent precision measurements of negatively charged
pion-proton and pion-deuteron scattering lengths from pionic atoms. We deduce
the charged-pion-nucleon coupling constant, with careful attention to
systematic and statistical uncertainties. This determination gives, directly
from data a pseudoscalar coupling constant of
14.11+-0.05(statistical)+-0.19(systematic) or a pseudovector one of 0.0783(11).
This value is intermediate between that of indirect methods and the direct
determination from backward neutron-proton differential scattering cross
sections. We also use the pionic atom data to deduce the coherent symmetric and
antisymmetric sums of the negatively charged pion-proton and pion-neutron
scattering lengths with high precision. The symmetric sum gives
0.0012+-0.0002(statistical)+-0.0008 (systematic) and the antisymmetric one
0.0895+-0.0003(statistical)+-0.0013(systematic), both in units of inverse
charged pion-mass. For the need of the present analysis, we improve the
theoretical description of the pion-deuteron scattering length.Comment: 27 pages, 5 figures, submitted to Phys. Rev. C, few modifications and
clarifications, no change in substance of the pape
Positive pion absorption on 3He using modern trinucleon wave functions
We study pion absorption on 3He employing trinucleon wave functions
calculated from modern realistic NN interactions (Paris, CD Bonn). Even though
the use of the new wave functions leads to a significant improvement over older
calculations with regard to both cross section and polarization data, there are
hints that polarization data with quasifree kinematics cannot be described by
just two-nucleon absorption mechanisms.Comment: 14 pages, 6 figure
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