153 research outputs found
The Role of Solid Friction in the Sedimentation of Strongly Attractive Colloidal Gels
We study experimentally and theoretically the sedimentation of gels made of
strongly aggregated colloidal particles, focussing on the long time behavior,
when mechanical equilibrium is asymptotically reached. The asymptotic gel
height is found to vary linearly with the initial height, a finding in stark
contrast with a recent study on similar gels [Manley \textit{et al.} 2005
\textit{Phys. Rev. Lett.} \textbf{94} 218302]. We show that the asymptotic
compaction results from the balance between gravity pull, network elasticity,
and solid friction between the gel and the container walls. Based on these
ingredients, we propose a simple model to account for the dependence of the
height loss on the initial height and volume fraction. As a result of our
analysis, we show that the static friction coefficient between the gel and the
container walls strongly depends on volume fraction: the higher the volume
fraction, the weaker the solid friction. This nonintuitive behavior is
explained using simple scaling arguments.Comment: 13 pages, 5 figures. Submitted to JSTA
The Influence of Different European Cements on the Transport and Early-age Properties of Concrete in the Cover-zone
The use of in situ tests for performance based specification would require demonstration of their suitability to distinguish the quality of concrete. With the introduction of new European Standards for cements, this would mean concretes produced with these new cements should be classified for their quality using the performance tests. It is generally believed that transport properties of concrete are related to their durability and hence the measurement of these properties can form the basis of performance based specifications. This paper reports data indicating that transport properties measured at 28-days for concretes manufactured with different European cements and water-binder ratios can form the basis of classifying concrete for their durability. The results also demonstrated how the different cements specified in European Standards influence the transport properties and other early-age properties
Microrheology, stress fluctuations and active behavior of living cells
We report the first measurements of the intrinsic strain fluctuations of
living cells using a recently-developed tracer correlation technique along with
a theoretical framework for interpreting such data in heterogeneous media with
non-thermal driving. The fluctuations' spatial and temporal correlations
indicate that the cytoskeleton can be treated as a course-grained continuum
with power-law rheology, driven by a spatially random stress tensor field.
Combined with recent cell rheology results, our data imply that intracellular
stress fluctuations have a nearly power spectrum, as expected for
a continuum with a slowly evolving internal prestress.Comment: 4 pages, 2 figures, to appear in Phys. Rev. Let
KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.
Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines. Recently K+ signaling has emerged as an important mediator of the inflammatory response to infection; we therefore investigated whether mice carrying an ENU induced activation of the electroneutral K+ channel KCC1 had an altered response to Plasmodium berghei. Here we show that Kcc1M935K/M935K mice are protected from the development of experimental cerebral malaria, and that this protection is associated with an increased CD4+ and TNFa response. This is the first description of a K+ channel affecting the development of experimental cerebral malaria
Optical microrheology using rotating laser-trapped particles
We demonstrate an optical system that can apply and accurately measure the
torque exerted by the trapping beam on a rotating birefringent probe particle.
This allows the viscosity and surface effects within liquid media to be
measured quantitatively on a micron-size scale using a trapped rotating
spherical probe particle. We use the system to measure the viscosity inside a
prototype cellular structure.Comment: 5 pages, 4 figures. v2: bibliographic details, minor text correction
Recommended from our members
Predicting suicides after outpatient mental health visits in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS).
The 2013 US Veterans Administration/Department of Defense Clinical Practice Guidelines (VA/DoD CPG) require comprehensive suicide risk assessments for VA/DoD patients with mental disorders but provide minimal guidance on how to carry out these assessments. Given that clinician-based assessments are not known to be strong predictors of suicide, we investigated whether a precision medicine model using administrative data after outpatient mental health specialty visits could be developed to predict suicides among outpatients. We focused on male nondeployed Regular US Army soldiers because they account for the vast majority of such suicides. Four machine learning classifiers (naive Bayes, random forests, support vector regression and elastic net penalized regression) were explored. Of the Army suicides in 2004-2009, 41.5% occurred among 12.0% of soldiers seen as outpatient by mental health specialists, with risk especially high within 26 weeks of visits. An elastic net classifier with 10-14 predictors optimized sensitivity (45.6% of suicide deaths occurring after the 15% of visits with highest predicted risk). Good model stability was found for a model using 2004-2007 data to predict 2008-2009 suicides, although stability decreased in a model using 2008-2009 data to predict 2010-2012 suicides. The 5% of visits with highest risk included only 0.1% of soldiers (1047.1 suicides/100 000 person-years in the 5 weeks after the visit). This is a high enough concentration of risk to have implications for targeting preventive interventions. An even better model might be developed in the future by including the enriched information on clinician-evaluated suicide risk mandated by the VA/DoD CPG to be recorded
Microrheology with optical tweezers: data analysis
We present a data analysis procedure that provides the solution to a long-standing issue in microrheology studies, i.e. the evaluation of the fluids' linear viscoelastic properties from the analysis of a finite set of experimental data, describing (for instance) the time-dependent mean-square displacement of suspended probe particles experiencing Brownian fluctuations. We report, for the first time in the literature, the linear viscoelastic response of an optically trapped bead suspended in a Newtonian fluid, over the entire range of experimentally accessible frequencies. The general validity of the proposed method makes it transferable to the majority of microrheology and rheology techniques
Donor–acceptor co-adsorption ratio controls the structure and electronic properties of two-dimensional alkali–organic networks on Ag(100)
P.T.P.R. and P.J.B. acknowledge financial support from Diamond Light Source and EPSRC. G.C. acknowledges financial support from the EU through the ERC Grant “VISUAL-MS” (Project ID: 308115). B.S. and R.J.M. acknowledge doctoral studentship funding from the EPSRC and the National Productivity Investment Fund (NPIF). R.J.M. acknowledges financial support via a UKRI Future Leaders Fellowship (MR/S016023/1).The results are presented of a detailed combined experimental and theoretical investigation of the influence of coadsorbed electron-donating alkali atoms and the prototypical electron acceptor molecule 7,7,8,8-tetracyanoquinodimethane (TCNQ) on the Ag(100) surface. Several coadsorption phases were characterized by scanning tunneling microscopy, low-energy electron diffraction, and soft X-ray photoelectron spectroscopy. Quantitative structural data were obtained using normal-incidence X-ray standing wave (NIXSW) measurements and compared with the results of density functional theory (DFT) calculations using several different methods of dispersion correction. Generally, good agreement between theory and experiment was achieved for the quantitative structures, albeit with the prediction of the alkali atom heights being challenging for some methods. The adsorption structures depend sensitively on the interplay of molecule–metal charge transfer and long-range dispersion forces, which are controlled by the composition ratio between alkali atoms and TCNQ. The large difference in atomic size between K and Cs has negligible effects on stability, whereas increasing the ratio of K/TCNQ from 1:4 to 1:1 leads to a weakening of molecule–metal interaction strength in favor of stronger ionic bonds within the two-dimensional alkali–organic network. A strong dependence of the work function on the alkali donor–TCNQ acceptor coadsorption ratio is predicted.Publisher PDFPeer reviewe
The performance of concrete exposed to marine environments: predictive modelling and use of laboratory/on site test method
This paper reports an approach by which laboratory based testing and numerical modelling can be combined to predict the long term performance of a range of concretes exposed to marine environments. Firstly, a critical review of the test methods for assessing the chloride penetration resistance of concrete is given. The repeatability of the different test results is also included. In addition to the test methods, a numerical simulation model is used to explore the test data further to obtain long-term chloride ingress trends. The combined use of testing and modelling is validated with the help of long-term chloride ingress data from a North Sea exposure site. In summary, the paper outlines a methodology for determining the long term performance of concrete in marine environments
- …