2,589 research outputs found
Gene Expression Signature in Adipose Tissue of Acromegaly Patients.
To study the effect of chronic excess growth hormone on adipose tissue, we performed RNA sequencing in adipose tissue biopsies from patients with acromegaly (n = 7) or non-functioning pituitary adenomas (n = 11). The patients underwent clinical and metabolic profiling including assessment of HOMA-IR. Explants of adipose tissue were assayed ex vivo for lipolysis and ceramide levels. Patients with acromegaly had higher glucose, higher insulin levels and higher HOMA-IR score. We observed several previously reported transcriptional changes (IGF1, IGFBP3, CISH, SOCS2) that are known to be induced by GH/IGF-1 in liver but are also induced in adipose tissue. We also identified several novel transcriptional changes, some of which may be important for GH/IGF responses (PTPN3 and PTPN4) and the effects of acromegaly on growth and proliferation. Several differentially expressed transcripts may be important in GH/IGF-1-induced metabolic changes. Specifically, induction of LPL, ABHD5, and NRIP1 can contribute to enhanced lipolysis and may explain the elevated adipose tissue lipolysis in acromegalic patients. Higher expression of TCF7L2 and the fatty acid desaturases FADS1, FADS2 and SCD could contribute to insulin resistance. Ceramides were not different between the two groups. In summary, we have identified the acromegaly gene expression signature in human adipose tissue. The significance of altered expression of specific transcripts will enhance our understanding of the metabolic and proliferative changes associated with acromegaly
Energy Density of Non-Minimally Coupled Scalar Field Cosmologies
Scalar fields coupled to gravity via in arbitrary
Friedmann-Robertson-Walker backgrounds can be represented by an effective flat
space field theory. We derive an expression for the scalar energy density where
the effective scalar mass becomes an explicit function of and the scale
factor. The scalar quartic self-coupling gets shifted and can vanish for a
particular choice of . Gravitationally induced symmetry breaking and
de-stabilization are possible in this theory.Comment: 18 pages in standard Late
Geometric structure of the generic static traversable wormhole throat
Traversable wormholes have traditionally been viewed as intrinsically
topological entities in some multiply connected spacetime. Here, we show that
topology is too limited a tool to accurately characterize a generic traversable
wormhole: in general one needs geometric information to detect the presence of
a wormhole, or more precisely to locate the wormhole throat. For an arbitrary
static spacetime we shall define the wormhole throat in terms of a
2-dimensional constant-time hypersurface of minimal area. (Zero trace for the
extrinsic curvature plus a "flare-out" condition.) This enables us to severely
constrain the geometry of spacetime at the wormhole throat and to derive
generalized theorems regarding violations of the energy conditions-theorems
that do not involve geodesic averaging but nevertheless apply to situations
much more general than the spherically symmetric Morris-Thorne traversable
wormhole. [For example: the null energy condition (NEC), when suitably weighted
and integrated over the wormhole throat, must be violated.] The major technical
limitation of the current approach is that we work in a static spacetime-this
is already a quite rich and complicated system.Comment: 25 pages; plain LaTeX; uses epsf.sty (four encapsulated postscript
figures
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Overestimating the Role of Environment in Cancers
In a recent article, Wu and colleagues (Nature 2016;529:43-47) review previous studies and present new estimates for the contribution of extrinsic factors to cancer development. The new estimates are generally close to 100%, even for bone and brain cancers that have no known associations with lifestyle and are typically not considered to be preventable. We find that the results of Wu and colleagues are incompatible with previous estimates derived from epidemiological and genetic data. We further argue that their methods are fundamentally flawed because they overlook important effects of tissue type on cancer risk. We therefore conclude that their results give a misleading view of cancer etiology and preventability. Cancer Prev Res; 9(10); 773-6. ©2016 AACR
Tolman wormholes violate the strong energy condition
For an arbitrary Tolman wormhole, unconstrained by symmetry, we shall define
the bounce in terms of a three-dimensional edgeless achronal spacelike
hypersurface of minimal volume. (Zero trace for the extrinsic curvature plus a
"flare-out" condition.) This enables us to severely constrain the geometry of
spacetime at and near the bounce and to derive general theorems regarding
violations of the energy conditions--theorems that do not involve geodesic
averaging but nevertheless apply to situations much more general than the
highly symmetric FRW-based subclass of Tolman wormholes. [For example: even
under the mildest of hypotheses, the strong energy condition (SEC) must be
violated.] Alternatively, one can dispense with the minimal volume condition
and define a generic bounce entirely in terms of the motion of test particles
(future-pointing timelike geodesics), by looking at the expansion of their
timelike geodesic congruences. One re-confirms that the SEC must be violated at
or near the bounce. In contrast, it is easy to arrange for all the other
standard energy conditions to be satisfied.Comment: 8 pages, ReV-TeX 3.
Heat kernel regularization of the effective action for stochastic reaction-diffusion equations
The presence of fluctuations and non-linear interactions can lead to scale
dependence in the parameters appearing in stochastic differential equations.
Stochastic dynamics can be formulated in terms of functional integrals. In this
paper we apply the heat kernel method to study the short distance
renormalizability of a stochastic (polynomial) reaction-diffusion equation with
real additive noise. We calculate the one-loop {\emph{effective action}} and
its ultraviolet scale dependent divergences. We show that for white noise a
polynomial reaction-diffusion equation is one-loop {\emph{finite}} in and
, and is one-loop renormalizable in and space dimensions. We
obtain the one-loop renormalization group equations and find they run with
scale only in .Comment: 21 pages, uses ReV-TeX 3.
Vacuum decay via Lorentzian wormholes
We speculate about the spacetime description due to the presence of
Lorentzian wormholes (handles in spacetime joining two distant regions or other
universes) in quantum gravity. The semiclassical rate of production of these
Lorentzian wormholes in Reissner-Nordstr\"om spacetimes is calculated as a
result of the spontaneous decay of vacuum due to a real tunneling
configuration. In the magnetic case it only depends on the field theoretical
fine structure constant. We predict that the quantum probability corresponding
to the nucleation of such geodesically complete spacetimes should be actually
negligible in our physical Universe
Low-dose solumatrix meloxicam demonstrates low systemic exposure and efficacy in patients with osteoarthitis pain in clinical studies
of the quantized fields in the Unruh state in the Schwarzschild spacetime
The renormalized expectation value of the stress energy tensor of the
conformally invariant massless fields in the Unruh state in the Schwarzschild
spacetime is constructed. It is achieved through solving the conservation
equation in conformal space and utilizing the regularity conditions in the
physical metric. The relations of obtained results to the existing
approximations are analysed.Comment: 17 pages, REVTE
Semiclassical charged black holes with a quantized massive scalar field
Semiclassical perturbations to the Reissner-Nordstrom metric caused by the
presence of a quantized massive scalar field with arbitrary curvature coupling
are found to first order in \epsilon = \hbar/M^2. The DeWitt-Schwinger
approximation is used to determine the vacuum stress-energy tensor of the
massive scalar field. When the semiclassical perturbation are taken into
account, we find extreme black holes will have a charge-to-mass ratio that
exceeds unity, as measured at infinity. The effects of the perturbations on the
black hole temperature (surface gravity) are studied in detail, with particular
emphasis on near extreme ``bare'' states that might become precisely zero
temperature ``dressed'' semiclassical black hole states. We find that for
minimally or conformally coupled scalar fields there are no zero temperature
solutions among the perturbed black holes.Comment: 19 pages; 1 figure; ReVTe
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