The most massive galaxies in clusters are already fully grown at z∼0.5z \sim 0.5

By constructing scaling relations for galaxies in the massive cluster MACSJ0717.5 at $z=0.545$ and comparing with those of Coma, we model the luminosity evolution of the stellar populations and the structural evolution of the galaxies. We calculate magnitudes, surface brightnesses and effective radii using HST/ACS images and velocity dispersions using Gemini/GMOS spectra, and present a catalogue of our measurements for 17 galaxies. We also generate photometric catalogues for $\sim 3000$ galaxies from the HST imaging. With these, we construct the colour-magnitude relation, the fundamental plane, the mass-to-light versus mass relation, the mass-size relation and the mass-velocity dispersion relation for both clusters. We present a new, coherent way of modelling these scaling relations simultaneously using a simple physical model in order to infer the evolution in luminosity, size and velocity dispersion as a function of redshift, and show that the data can be fully accounted for with this model. We find that (a) the evolution in size and velocity dispersion undergone by these galaxies between $z \sim 0.5$ and $z \sim 0$ is mild, with $R_e(z) \sim (1+z)^{-0.40\pm0.32}$ and $\sigma(z) \sim (1+z)^{0.09 \pm 0.27}$, and (b) the stellar populations are old, $\sim 10$ Gyr, with a $\sim 3$ Gyr dispersion in age, and are consistent with evolving purely passively since $z \sim 0.5$ with $\Delta \log M/L_B = -0.55_{-0.07}^{+0.15} z$. The implication is that these galaxies formed their stars early and subsequently grew dissipationlessly so as to have their mass already in place by $z \sim 0.5$, and suggests a dominant role for dry mergers, which may have accelerated the growth in these high-density cluster environments.Comment: 20 pages; accepted for publication in MNRA

The fundamental plane of evolving red nuggets

We present an exploration of the mass structure of a sample of 12 strongly lensed massive, compact early-type galaxies at redshifts $z\sim0.6$ to provide further possible evidence for their inside-out growth. We obtain new ESI/Keck spectroscopy and infer the kinematics of both lens and source galaxies, and combine these with existing photometry to construct (a) the fundamental plane (FP) of the source galaxies and (b) physical models for their dark and luminous mass structure. We find their FP to be tilted towards the virial plane relative to the local FP, and attribute this to their unusual compactness, which causes their kinematics to be totally dominated by the stellar mass as opposed to their dark matter; that their FP is nevertheless still inconsistent with the virial plane implies that both the stellar and dark structure of early-type galaxies is non-homologous. We also find the intrinsic scatter of their FP to be comparable to the local value, indicating that variations in the stellar mass structure outweight variations in the dark halo in the central regions of early-type galaxies. Finally, we show that inference on the dark halo structure -- and, in turn, the underlying physics -- is sensitive to assumptions about the stellar initial mass function (IMF), but that physically-motivated assumptions about the IMF imply haloes with sub-NFW inner density slopes, and may present further evidence for the inside-out growth of compact early-type galaxies via minor mergers and accretion.Comment: 10 pages, 3 figures, 3 tables; submitted to MNRA

Insights from the x-ray crystal structure of coral 8R-lipoxygenase: Calcium activation via a C2-like domain and a structural basis of product chirality

Lipoxygenases (LOXs) catalyze the regio- and stereospecific dioxygenation of polyunsaturated membrane-embedded fatty acids. We report here the 3.2 Å resolution structure of 8R-LOX from the Caribbean sea whip coral Plexaura homomalla, a LOX isozyme with calcium dependence and the uncommon R chiral stereospecificity. Structural and spectroscopic analyses demonstrated calcium binding in a C2-like membrane-binding domain, illuminating the function of similar amino acids in calcium-activated mammalian 5-LOX, the key enzyme in the pathway to the pro-inflammatory leukotrienes. Mutation of Ca2+- ligating amino acids in 8R-LOX resulted not only in a diminished capacity to bind membranes, as monitored by fluorescence resonance energy transfer, but also in an associated loss of Ca2+-regulated enzyme activity. Moreover, a structural basis for R chiral specificity is also revealed; creation of a small oxygen pocket next to Gly428 (Ala in all S-LOX isozymes) promoted C-8 oxygenation with R chirality on the activated fatty acid substrate. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc

Structural geomorphic analysis of the Virginia Mountains, Washoe County, Nevada

Online access for this thesis was created in part with support from the Institute of Museum and Library Services (IMLS) administered by the Nevada State Library, Archives and Public Records through the Library Services and Technology Act (LSTA). To obtain a high quality image or document please contact the DeLaMare Library at https://unr.libanswers.com/ or call: 775-784-6945.The Virginia Mountains of Washoe County, Nevada, is an uplifted and collapsed anticlinal structure having a N-S trend but bending toward the southeast at the southern end of the range. NW and NNW fault trends in Winnemucca Valley and within the low hills on the eastern range front are believed to be a part of the Walker Lane lineament. Topographic, structural, and geologic evidence yields confidently a first-order, right-lateral, strike-slip fault interpretation. Also indicated are second-order left-lateral, strike slip movements along the eastern mountain front. The structurally very complex southern one-fifth of the range together with the northern portion of the Pah Rah Range suggest distributive branching of the Walker Lane lineament in the brittle Hartford Hill rhyolite as the lineament nears termination in southern Washoe County. The present topography of the Virginia Mountains is the result of bending of layers of volcanic rocks, high- angle and strike-slip faulting, and erosion in an arid to semi-arid climate. Major and minor drainage is controlled almost exclusively by the structure. Fault valleys are characteristic of the entire range and are the principal topographic forms, but many other types of drainage are present. The higher elevations are representative of old erosion surfaces

Red nuggets grow inside-out: evidence from gravitational lensing

We present a new sample of strong gravitational lens systems where both the foreground lenses and background sources are early-type galaxies. Using imaging from HST/ACS and Keck/NIRC2, we model the surface brightness distributions and show that the sources form a distinct population of massive, compact galaxies at redshifts $0.4 \lesssim z \lesssim 0.7$, lying systematically below the size-mass relation of the global elliptical galaxy population at those redshifts. These may therefore represent relics of high-redshift red nuggets or their partly-evolved descendants. We exploit the magnifying effect of lensing to investigate the structural properties, stellar masses and stellar populations of these objects with a view to understanding their evolution. We model these objects parametrically and find that they generally require two S\'ersic components to properly describe their light profiles, with one more spheroidal component alongside a more envelope-like component, which is slightly more extended though still compact. This is consistent with the hypothesis of the inside-out growth of these objects via minor mergers. We also find that the sources can be characterised by red-to-blue colour gradients as a function of radius which are stronger at low redshift -- indicative of ongoing accretion -- but that their environments generally appear consistent with that of the general elliptical galaxy population, contrary to recent suggestions that these objects are predominantly associated with clusters.Comment: 21 pages; accepted for publication in MNRA

Association of the Covid-19 lockdown with smoking, drinking, and attempts to quit in England: an analysis of 2019-2020 data

Aim: To examine changes in smoking, drinking and quitting/reduction behaviour following the COVID‐19 lockdown in England. Design/setting: Monthly cross‐sectional surveys representative of the adult population in England, aggregated before (April 2019–February 2020) versus after (April 2020) lockdown. Participants: A total of 20 558 adults (≥ 16 years). Measurements: The independent variable was the timing of the COVID‐19 lockdown (before versus after March 2020). Dependent variables were: prevalence of smoking and high‐risk drinking, past‐year cessation and quit attempts (among past‐year smokers), past‐year attempts to reduce alcohol consumption (among high‐risk drinkers) and use of evidence‐based (e.g. prescription medication/face‐to‐face behavioural support) and remote support [telephone support/websites/applications (apps)] for smoking cessation and alcohol reduction (among smokers/high‐risk drinkers who made a quit/reduction attempt). Covariates included age, sex, social grade, region and level of nicotine and alcohol dependence (as relevant). Findings: The COVID‐19 lockdown was not associated with a significant change in smoking prevalence [17.0% (after) versus 15.9% (before), odds ratio (OR) = 1.09, 95% CI = 0.95–1.24], but was associated with increases in quit attempts [39.6 versus 29.1%, adjusted odds ratio (ORadj) = 1.56, 95% CI = 1.23–1.98], quit success (21.3 versus 13.9%, ORadj = 2.01, 95% CI = 1.22–3.33) and cessation (8.8 versus 4.1%, ORadj = 2.63, 95% CI = 1.69–4.09) among past‐year smokers. Among smokers who tried to quit, there was no significant change in use of evidence‐based support (50.0 versus 51.5%, ORadj = 1.10, 95% CI = 0.72–1.68) but use of remote support increased (10.9 versus 2.7%, ORadj = 3.59, 95% CI = 1.56–8.23). Lockdown was associated with increases in high‐risk drinking (38.3 versus 25.1%, OR = 1.85, CI = 1.67–2.06), but also alcohol reduction attempts by high‐risk drinkers (28.5 versus 15.3%, ORadj = 2.16, 95% CI = 1.77–2.64). Among high‐risk drinkers who made a reduction attempt, use of evidence‐based support decreased (1.2 versus 4.0%, ORadj = 0.23, 95% CI = 0.05–0.97) and there was no significant change in use of remote support (6.9 versus 6.1%, ORadj = 1.32, 95% CI = 0.64–2.75). Conclusions: Following the March 2020 COVID‐19 lockdown, smokers and high‐risk drinkers in England were more likely than before lockdown to report trying to quit smoking or reduce alcohol consumption and rates of smoking cessation and use of remote cessation support were higher. However, high‐risk drinking prevalence increased post‐lockdown and use of evidence‐based support for alcohol reduction by high‐risk drinkers decreased with no compensatory increase in use of remote support

Radiation Test Challenges for Scaled Commerical Memories

As sub-100nm CMOS technologies gather interest, the radiation effects performance of these technologies provide a significant challenge. In this talk, we shall discuss the radiation testing challenges as related to commercial memory devices. The focus will be on complex test and failure modes emerging in state-of-the-art Flash non-volatile memories (NVMs) and synchronous dynamic random access memories (SDRAMs), which are volatile. Due to their very high bit density, these device types are highly desirable for use in the natural space environment. In this presentation, we shall discuss these devices with emphasis on considerations for test and qualification methods required