Candidate genes and clinical-laboratory parameters in pregnant women with preeclampsia

They studied the associations of genetic polymorphisms with clinico-laboratory indicators among pregnant women with preeclampsia depending on hereditary complicatio

Soliton absorption spectroscopy

We analyze optical soliton propagation in the presence of weak absorption lines with much narrower linewidths as compared to the soliton spectrum width using the novel perturbation analysis technique based on an integral representation in the spectral domain. The stable soliton acquires spectral modulation that follows the associated index of refraction of the absorber. The model can be applied to ordinary soliton propagation and to an absorber inside a passively modelocked laser. In the latter case, a comparison with water vapor absorption in a femtosecond Cr:ZnSe laser yields a very good agreement with experiment. Compared to the conventional absorption measurement in a cell of the same length, the signal is increased by an order of magnitude. The obtained analytical expressions allow further improving of the sensitivity and spectroscopic accuracy making the soliton absorption spectroscopy a promising novel measurement technique.Comment: 9 pages, 7 figures

Broadband dispersion measurement of ZBLAN, germanate and silica fibers in MidIR

We report the first ultra-broad band dispersion measurements in short-length ZBLAN, germanate and silica-based optical fibers in the near- and midIR wavelength ranges between 1.7 and 2.0 μ m and from 2.3 to 2.45 μm, using two ultra-broadband light sources: a broadband superluminescent Tm-doped fiber source and a novel femtosecond pulsed mode-locked Cr:ZnS oscillator. The measured second order dispersion characteristics of the fibers correspond to the theoretical predictions (numerical calculations)

Management of the educational and production environment of the enterprise in the dual preparation of students

Рассматривается учебно-производственная среда предприятия, реализуемая в виде наставничества при дуальной подготовке обучающихсяThe article examines the educational and production environment of the enterprise, which is implemented in the form of mentoring with dual training of student

METHODS AND TECHNOLOGY FOR ASSESSMENT OF HUMAN CAPITAL OF A UNIVERSITY GRADUATE

Purpose: The article presents the author's approach to assessing the human capital of a graduate of a regional university. Emphasis is placed on the fact that the problem of assessing of human capital is especially acute for pedagogy, since the contribution of education to the formation of human capital is one of the determining factors, and the contribution of pedagogy to the study of the pedagogical aspects of this phenomenon is extremely small. Methodology: The authors propose a methodology and technology for assessing human capital. In particular, it was proposed to use an integrated approach to the assessment of human capital of a graduate of a regional university, the essence of which is to add the absolute values of indicators of individual components of capital, and then based on the data calculate the relative indicator of the quality of human capital. Result: The result of training and the main goal of improving the quality of training of specialists at a regional university will be to ensure the minimum deviation of the level of the human capital of the graduate achieved during the period of study at the university, from the level of human capital established by regulatory requirements

T-bet syndrome-associated bronchial asthma phenotype

We aimed to evaluate a significance of T-bet transcription factor in bronchial asthma (BA). A total of 102 patients with BA were examined. The control group was represented by healthy subjects (21 people). The study model was represented by peripheral blood mononuclear cells isolated in a density gradient with standard method. It was found that some patients were characterized by high levels of transcription factor T-bet expression (T-bet > 1.0). The bronchial asthma patients with increased T-bet expression were moir often characterized by the severe disease, requiring therapy with systemic glucocorticoids and β2-agonists, did not have genetic predisposal for allergic diseases, the majority of them had excess body weight and concomitant morbidity (mainly, cardiovascular, gastrointestinal and endocrine disorders). The study of rs324011 polymorphism of STAT6 protein gene in these patients revealed CC and CT genotypes, mostly observed in severe BA. Moreover, they were observed in 100% patients with severe clinical course of BA. A positive correlation was found between the number of T allele presentation in loci, and BA severity (r = 0.88, p = 0.002), as well as between the distribution by genotype (CC-CT/TT), and absolute (counts per one L), and relative (%) number of eosinophils in the sputum (r = 0.79, p = 0.034). The detected associations may be referred to as “T-bet elevation syndrome”, being based on the phenomenon of “genetically determined heterogeneity of signaling system defects”. In individuals with an increased T-bet expression, a significant elevation of transcription factors STAT6 and STAT4 was also detected. Taken together, the presented data indicate that this phenomenon reflects a disturbance of the Th1 / Th2 balance, due to increase in both Th1 and Th2 transcriptional activity. Thus, the patients with bronchial asthma with increased expression of T-bet transcription factor revealed a symptom complex, which we have called “T-bet elevation syndrome” (T-bet > 1.0), which is characterized mainly by severe disease and a certain phenotype of patients. Most likely, this feature is caused by genetically determined defects of signaling systems. High T-bet expression has been observed in young patients with mild BA and can be a prognostic sign

ЗАЩИТИТЬ УРОЖАЙ И ЗЕМЛЮ: НОВЫЕ ТЕХНОЛОГИИ В МУЛЬЧИРОВАНИИ

Biodegradable ecovio® plastic films for mulching is a solution of BASF engineering.It offers the excellent mechanical properties, and it is completely destructedas polymer is to be fully composted. Without recycling this covering plastic filmis entirely digested by soil microorganisms. The only thing is to do after harvestingis to bury scraps of plastics into the soil to start the process of biodigestion. Development of ecovio® solution opens new page for wide use of this technology in agriculture. The usage of biodegradable plastic films has shown the good results in plant nursery gardens, vegetable and grape growing.Разработка немецкого концерна BASF – биоразлагаемая пленка ecovio® для мульчирования. Она обладает великолепной механической прочностью, но при этом является полностью разлагаемым и компостируемым полимером. Этот укрывной материал не требует утилизации, его переработают обычные почвенные микроорганизмы, достаточно после сбора урожая закопать остатки пленки, и процесс биоразложения начнется. Создание ecovio® открывает новую страницу в использовании полимеров в сельском хозяйстве в больших объемах. Применение биоразлагаемой пленки показало высокие результаты на овощных культурах, в виноградниках и питомниках

RISK ASSESSMENT OF THE PRESENCE OF SILENT MYOCARDIAL ISCHEMIA IN TYPE 2 DIABETIC PATIENTS

Purpose: testing in clinical practice a mathematical model of risk assessment of the presence of silent myocardial ischemia (SMI) in type 2 diabetic patients.Material and Methods: 55 type 2 diabetic patients have been studied; among them 26 (47,27%) men and 29 (52,73%) women, mean age – 57,79 ± 8,39 years, diabetes duration – 9,65 ± 6,41 years. Identified 11 parameters included in the model. Calculated and assessed the presence of factor SMI. To verify the diagnosis, all patients completed ECG monitoring with mandatory achievement of submaximal heart rate.Results: Higher risk of having SMI was detected in 14 (25.45%) patients, low risk - in 41 (74.54%). SMI was diagnosed in 10 (71.43%) patients at high risk. In patients at low risk SIM was not found. Thus, the sensitivity of the model was 100%, specificity - 91%, the positive predictive value - 71%, and the negative - 100%.Conclusions: This mathematical model assesses the risk of having a SMI in type 2 diabetic patients and can be used in actual practice to optimize early detection of this disease

EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA

We observed sixty patients with allergic bronchial asthma (ABA) and 54 with non-allergic bronchial asthma (NABA). Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectively of pathogenetic form), a significant increase of SOCS3 transcription factor expression was detected in peripheral blood mononuclears, as compared with control group. This increase was more pronounced in NABA group. The mRNA SOCS5 level was significantly decreased in bronchial asthma patients, as compared to control group, especially, in ABA subgroup rather than in NABA patients. Thus, an increased expression of SOCS3 mRNA in BA patients could be regarded as a protective antiinflammatory response Decrease of SOCS5 mRNA expression in patients with bronchial asthma (being more pronounced in ABA), may be indicative for a deficiency in negative feedback regulation of gene transcription in allergic bronchial asthma