Electronic and optical properties of new synthesized TTF-based azine derivatives – Experimental and theoretical study

The synthesis and detailed characterization of two tetrathiafulvalene-appended azine derivatives, namely 2-([2,2′-bi(1,3-dithiolylidene)]-4-yl)-6-((2,4-dimethylphenyl)hydrazono) methyl)pyridine (L1) and 5-([2,2′-bi(1,3-dithiolylidene)]-4-yl)-2-((2,4-dimethylphenyl)hydrazono) methyl)pyridine (L2) are described. The crystal structure of ligand L2 indicates that the mentioned molecule is completely planar with the presence of a strong intramolecular N1 [single bond] H1⋯N3 hydrogen bonding. The quantum chemical calculations show that the intermolecular interaction in crystal structure does not affect the HOMO and LUMO orbitals present in isolated molecule. The optical properties of these ligands indicate the presence of intramolecular charge transfer band in the case of ligand L2 while the electrochemical behavior of the two compounds indicates that they are valuable candidates for the construction of crystalline radical cation salts

Theoretical and experimental investigation of multifunctional highly conjugated organic push-pull ligands for NLO applications

International audienc

European survey of newborn bloodspot screening for CF: opportunity to address challenges and improve performance

Background: The aim of this study was to record the current status of newborn bloodspot screening (NBS) for CF across Europe and assess performance. Methods: Survey of representatives of NBS for CF programmes across Europe. Performance was assessed through a framework developed in a previous exercise. Results: In 2022, we identified 22 national and 34 regional programmes in Europe. Barriers to establishing NBS included cost and political inertia. Performance was assessed from 2019 data reported by 21 national and 21 regional programmes. All programmes employed different protocols, with IRT-DNA the most common strategy. Six national and 11 regional programmes did not use DNA analysis. Conclusions: Integrating DNA analysis into the NBS protocol improves PPV, but at the expense of increased carrier and CFSPID recognition. Some programmes employ strategies to mitigate these outcomes. Programmes should constantly strive to improve performance but large datasets are needed to assess outcomes reliably

Preface

International audienc