Role Reinvention, Structural Defense, or Resigned Surrender: Institutional Approaches to Technological Change and Reference Librarianship

In a comparative field study of ten libraries, we show how technological advances in electronic and digital resources have led to an onslaught of technology questions at the reference desk while prompting new and challenging work away from the desk. Libraries in our sample varied in their approaches to dealing with technological change, with institutional factors appearing to strongly shape their choice. Large, four-year academic libraries adopted a role reinvention approach that reduced reference librarians\u27 desk hours and permitted librarians to follow creative, often technical, pursuits. Small, four-year academic libraries took a structural defense approach that maintained the sanctity of the reference desk as the locus for substantive reference questions. Two-year academic and public libraries followed a resigned surrender approach where reference librarians staffed busy desks and were inundated with patron requests to aid with computer equipment. We discuss the implications of each approach for the work of reference librarians

Electron, ion and neutral temperatures at the magnetic equator

Electron density and electron, ion, and neutral temperature profiles at magnetic equato

An objective approach for Burkholderia pseudomallei strain selection as challenge material for medical countermeasures efficacy testing

Burkholderia pseudomallei is the causative agent of melioidosis, a rare disease of biodefense concern with high mortality and extreme difficulty in treatment. No human vaccines are available that protect against B. pseudomallei infection, and with the current limitations of antibiotic treatment, the development of new preventative and therapeutic interventions is crucial. Although clinical trials could be used to test the efficacy of new medical countermeasures (MCMs), the high mortality rates associated with melioidosis raises significant ethical issues concerning treating individuals with new compounds with unknown efficacies. The US Food and Drug Administration (FDA) has formulated a set of guidelines for the licensure of new MCMs to treat diseases in which it would be unethical to test the efficacy of these drugs in humans. The FDA “Animal Rule” 21 CFR 314 calls for consistent, well-characterized B. pseudomallei strains to be used as challenge material in animal models. In order to facilitate the efficacy testing of new MCMs for melioidosis using animal models, we intend to develop a well-characterized panel of strains for use. This panel will comprise of strains that were isolated from human cases, have a low passage history, are virulent in animal models, and are well-characterized phenotypically and genotypically. We have reviewed published and unpublished data on various B. pseudomallei strains to establish an objective method for selecting the strains to be included in the panel of B. pseudomallei strains with attention to five categories: animal infection models, genetic characterization, clinical and passage history, and availability of the strain to the research community. We identified 109 strains with data in at least one of the five categories, scored each strain based on the gathered data and identified six strains as candidate for a B. pseudomallei strain panel

Incoherent backscatter observations of the F region during the November 12, 1966 solar eclipse

Incoherent backscatter observations of F region during solar eclips

Long beating wavelength in the Schwarz-Hora effect

Thirty years ago, H.Schwarz has attempted to modulate an electron beam with optical frequency. When a 50-keV electron beam crossed a thin crystalline dielectric film illuminated with laser light, electrons produced the electron-diffraction pattern not only at a fluorescent target but also at a nonfluorescent target. In the latter case the pattern was of the same color as the laser light (the Schwarz-Hora effect). This effect was discussed extensively in the early 1970s. However, since 1972 no reports on the results of further attempts to repeat those experiments in other groups have appeared, while the failures of the initial such attempts have been explained by Schwarz. The analysis of the literature shows there are several unresolved up to now contradictions between the theory and the Schwarz experiments. In this work we consider the interpretation of the long-wavelength spatial beating of the Schwarz-Hora radiation. A more accurate expression for the spatial period has been obtained, taking into account the mode structure of the laser field within the dielectric film. It is shown that the discrepancy of more than 10% between the experimental and theoretical results for the spatial period cannot be reduced by using the existing quantum models that consider a collimated electron beam.Comment: 3 pages, RevTe

Acoustic Spectroscopy of the DNA in GHz range

We find a parametric resonance in the GHz range of the DNA dynamics, generated by pumping hypersound . There are localized phonon modes caused by the random structure of elastic modulii due to the sequence of base pairs

On the nonlinear dynamics of topological solitons in DNA

Dynamics of topological solitons describing open states in the DNA double helix are studied in the frameworks of the model which takes into account asymmetry of the helix. It is shown that three types of topological solitons can occur in the DNA double chain. Interaction between the solitons, their interactions with the chain inhomogeneities and stability of the solitons with respect to thermal oscillations are investigated.Comment: 16 pages, 16 figure

Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons

Somatosensory thalamocortical (TC) neurons from the ventrobasal (VB) thalamus are central components in the flow of sensory information between the periphery and the cerebral cortex, and participate in the dynamic regulation of thalamocortical states including wakefulness and sleep. This property is reflected at the cellular level by the ability to generate action potentials in two distinct firing modes, called tonic firing and low-threshold bursting. Although the general properties of TC neurons are known, we still lack a detailed characterization of their morphological and electrical properties in the VB thalamus. The aim of this study was to build biophysically-detailed models of VB TC neurons explicitly constrained with experimental data from rats. We recorded the electrical activity of VB neurons (N = 49) and reconstructed morphologies in 3D (N = 50) by applying standardized protocols. After identifying distinct electrical types, we used a multi-objective optimization to fit single neuron electrical models (e-models), which yielded multiple solutions consistent with the experimental data. The models were tested for generalization using electrical stimuli and neuron morphologies not used during fitting. A local sensitivity analysis revealed that the e-models are robust to small parameter changes and that all the parameters were constrained by one or more features. The e-models, when tested in combination with different morphologies, showed that the electrical behavior is substantially preserved when changing dendritic structure and that the e-models were not overfit to a specific morphology. The models and their analysis show that automatic parameter search can be applied to capture complex firing behavior, such as co-existence of tonic firing and low-threshold bursting over a wide range of parameter sets and in combination with different neuron morphologies

Salience-based selection: attentional capture by distractors less salient than the target

Current accounts of attentional capture predict the most salient stimulus to be invariably selected first. However, existing salience and visual search models assume noise in the map computation or selection process. Consequently, they predict the first selection to be stochastically dependent on salience, implying that attention could even be captured first by the second most salient (instead of the most salient) stimulus in the field. Yet, capture by less salient distractors has not been reported and salience-based selection accounts claim that the distractor has to be more salient in order to capture attention. We tested this prediction using an empirical and modeling approach of the visual search distractor paradigm. For the empirical part, we manipulated salience of target and distractor parametrically and measured reaction time interference when a distractor was present compared to absent. Reaction time interference was strongly correlated with distractor salience relative to the target. Moreover, even distractors less salient than the target captured attention, as measured by reaction time interference and oculomotor capture. In the modeling part, we simulated first selection in the distractor paradigm using behavioral measures of salience and considering the time course of selection including noise. We were able to replicate the result pattern we obtained in the empirical part. We conclude that each salience value follows a specific selection time distribution and attentional capture occurs when the selection time distributions of target and distractor overlap. Hence, selection is stochastic in nature and attentional capture occurs with a certain probability depending on relative salience