Thermal Relics in Modified Cosmologies: Bounds on Evolution Histories of the Early Universe and Cosmological Boosts for PAMELA

Alternative cosmologies, based on extensions of General Relativity, predict modified thermal histories in the Early Universe during the pre Big Bang Nucleosynthesis (BBN) era, epoch which is not directly constrained by cosmological observations. When the expansion rate is enhanced with respect to the standard case, thermal relics typically decouple with larger relic abundances. The correct value of the relic abundance is therefore obtained for larger annihilation cross--sections, as compared to standard cosmology. A direct consequence is that indirect detection rates are enhanced. Extending previous analyses of ours, we derive updated astrophysical bounds on the dark matter annihilation cross sections and use them to constrain alternative cosmologies in the pre--BBN era. We also determine the characteristics of these alternative cosmologies in order to provide the correct value of relic abundance for a thermal relic for the (large) annihilation cross--section required to explain the PAMELA results on the positron fraction, therefore providing a "cosmological boost" solution to the dark matter interpretation of the PAMELA data.Comment: 19 pages, 27 figures, matches published versio

Prosthetic abdominal wall hernia repair in emergency surgery: from polypropylene to biological meshes

The use of nonabsorbable prosthetic materials such as polypropylene, polyester, and ePTFE, have expanded and are now widely used in reparative surgery for abdominal wall hernias

Axion-Dilaton Cosmology and Dark Energy

We discuss a class of flat FRW cosmological models based on D=4 axion-dilaton gravity universally coupled to cosmological background fluids. In particular, we investigate the possibility of recurrent acceleration, which was recently shown to be generically realized in a wide class of axion-dilaton models, but in absence of cosmological background fluids. We observe that, once we impose the existence of radiation -and matter- dominated earlier stages of cosmic evolution, the axion-dilaton dynamics is altered significantly with respect to the case of pure axion-dilaton gravity. During the matter dominated epoch the scalar fields remain either frozen, due to the large expansion rate, or enter a cosmological scaling regime. In both cases, oscillations of the effective equation of state around the acceleration boundary value are impossible. Models which enter an oscillatory stage in the low redshift regime, on the other hand, are disfavored by observations. We also comment on the viability of the axion-dilaton system as a candidate for dynamical dark energy. In a certain subclass of models, an intermediate scaling regime is succeeded by eternal acceleration. We also briefly discuss the issue of dependence on initial conditions.Comment: 28 pages, 11 figure

Analyzing Direct Dark Matter Detection Data by the AMIDAS Website

In this talk I have presented the data analysis results of extracting properties of halo WIMPs: the mass and the (ratios between the) spin-independent and spin-dependent couplings/cross sections on nucleons by the AMIDAS website. Although non-standard astronomical setup has been used to generate pseudodata sets for our analyses, it has been found that, without prior information/assumption about the local density and velocity distribution of halo Dark Matter, these WIMP properties have been reconstructed with ~5% to < ~40% deviations from the input values.Comment: 12 pages, 8 eps figures, 1 table, to appear in the proceedings of the 3rd Workshop on Directional Detection of Dark Matter (CYGNUS 2011), June 7-10, 2011, Aussois, Franc

Dark Matter Relic Abundance and Scalar-Tensor Dark Energy

Scalar-tensor theories of gravity provide a consistent framework to accommodate an ultra-light quintessence scalar field. While the equivalence principle is respected by construction, deviations from General Relativity and standard cosmology may show up at nucleosynthesis, CMB, and solar system tests of gravity. After imposing all the bounds coming from these observations, we consider the expansion rate of the universe at WIMP decoupling, showing that it can lead to an enhancement of the dark matter relic density up to few orders of magnitude with respect to the standard case. This effect can have an impact on supersymmetric candidates for dark matter.Comment: 12 pages, 13 figures; V2: references added, matches published versio

Dynamical Relaxation of the Dark Matter to Baryon Ratio

A scalar field interacting differently with dark matter and baryons may explain why their ratio is of order unity today. We provide three working examples, checking them against the observations of CMB, Large Scale Structure, supernovae Ia, and post-newtonian tests of gravity. Such a scenario could make life much easier for supersymmetric dark matter candidates.Comment: 7 pages, 5 .eps figures. Discussion of the approach of the field to the fixed point added. Figures modified accordingly. Conclusions unchanged. Version to be published on Phys Rev.

Probing the stability of superheavy dark matter particles with high-energy neutrinos

Two of the most fundamental properties of the dark matter particle, the mass and the lifetime, are only weakly constrained by the astronomical and cosmological evidence of dark matter. We derive in this paper lower limits on the lifetime of dark matter particles with masses in the range 10 TeV-10^15 TeV from the non-observation of ultrahigh energy neutrinos in the AMANDA, IceCube, Auger and ANITA experiments. For dark matter particles which produce neutrinos in a two body or a three body decay, we find that the dark matter lifetime must be longer than O(10^26-10^28) s for masses between 10 TeV and the Grand Unification scale. Finally, we also calculate, for concrete particle physics scenarios, the limits on the strength of the interactions that induce the dark matter decay.Comment: 17 pages, 6 figures; v2: references added, discussion improved, matches the version published at JCA

Emergency surgery for recurrent intraabdominal cancer

Recurrent abdominal cancer can manifest in many ways but there are certain situations that are a great challenge to clinicians. Emergency presentation is one such situation. Surgeons are faced with a therapeutic dilemma that on the one hand most of these patients have a limited life expectancy, and on the other surgical procedures are unavoidable. We reviewed our experience of recurrent abdominal cancers presenting with acute abdominal symptoms requiring emergency

Insulin Resistance and High Blood Pressure: Mechanistic Insight on the Role of the Kidney

The metabolic effects of insulin predominate in skeletal muscle, fat, and liver where the hormone binds to its receptor, thereby priming a series of cell-specific and biochemically diverse intracellular mechanisms. In the presence of a good secretory reserve in the pancreatic islets, a decrease in insulin sensitivity in the metabolic target tissues leads to compensatory hyperinsulinemia. A large body of evidence obtained in clinical and experimental studies indicates that insulin resistance and the related hyperinsulinemia are causally involved in some forms of arterial hypertension. Much of this involvement can be ascribed to the impact of insulin on renal sodium transport, although additional mechanisms might be involved. Solid evidence indicates that insulin causes sodium and water retention, and both endogenous and exogenous hyperinsulinemia have been correlated to increased blood pressure. Although important information was gathered on the cellular mechanisms that are triggered by insulin in metabolic tissues and on their abnormalities, knowledge of the insulin-related mechanisms possibly involved in blood pressure regulation is limited. In this review, we summarize the current understanding of the cellular mechanisms that are involved in the pro-hypertensive actions of insulin, focusing on the contribution of insulin to the renal regulation of sodium balance and body fluids

Polyphenols rich diets and risk of type 2 diabetes

Type 2 diabetes is an increasing health concern worldwide. Both genetic and environmental risk factors as improper dietary habits or physical inactivity are known to be crucial in the pathogen-esis of type 2 diabetes. Polyphenols are a group of plant-derived compounds with anti-inflammatory and antioxidant properties that are associated with a low prevalence of metabolic conditions charac-terized by insulin resistance, including obesity, diabetes, and hypertension. Moreover, there is now full awareness that foods that are rich in phytochemicals and polyphenols could play an important role in preserving human cardiovascular health and substantial clinical evidence indicates that regu-lar dietary consumption of such foods affects favorably carbohydrate metabolism. This review briefly summarizes the evidence relating dietary patterns rich in polyphenols with glucose metabolism and highlights the potential benefits of these compounds in the prevention of type 2 diabetes