RNase T1 mimicking artificial ribonuclease

Recently, artificial ribonucleases (aRNases)—conjugates of oligodeoxyribonucleotides and peptide (LR)4-G-amide—were designed and assessed in terms of the activity and specificity of RNA cleavage. The conjugates were shown to cleave RNA at Pyr-A and G–X sequences. Variations of oligonucleotide length and sequence, peptide and linker structure led to the development of conjugates exhibiting G–X cleavage specificity only. The most efficient catalyst is built of nonadeoxyribonucleotide of unique sequence and peptide (LR)4-G-NH2 connected by the linker of three abasic deoxyribonucleotides (conjugate pep-9). Investigation of the cleavage specificity of conjugate pep-9 showed that the compound is the first single-stranded guanine-specific aRNase, which mimics RNase T1. Rate enhancement of RNA cleavage at G–X linkages catalysed by pep-9 is 108 compared to non-catalysed reaction, pep-9 cleaves these linkages only 105-fold less efficiently than RNase T1 (kcat_RNase T1/kcat_pep-9 = 105)

Laplace invariants for a generalized Boussinesq-Love equation

© 2015, Pleiades Publishing, Ltd. We construct Laplace invariants for an equation with a dominating fourth partial derivative. The determining equations are written out in terms of the Laplace invariants. We single out classes of equations admitting four-dimensional Lie algebras

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© 2015, Pleiades Publishing, Ltd. We construct Laplace invariants for an equation with a dominating fourth partial derivative. The determining equations are written out in terms of the Laplace invariants. We single out classes of equations admitting four-dimensional Lie algebras

Laplace invariants for a fourth-order equation with two independent variables

We construct the Laplace invariants for an equation with the leading partial derivative. We write defining equations in terms of the Laplace invariants. We obtain classes of equations admitting four-dimensional Lie algebras. © 2014 Allerton Press, Inc

On Laplace invariants for equations with dominating third-order partial derivative and two independent variables

© 2016, Pleiades Publishing, Ltd.Laplace invariants are constructed and the constitutive equations are written in terms of them. Classes of equations which admit four-dimensional Lie algebras are distinguished

The minimal compound-complex sentence hierarchy

This article deals with the problem of the study of the subsystem of such type of the Multiple Compound-Complex Sentence as a minimal compound-complex sentence. The authors analyze the formal structure of the multiple compoundcomplex sentences and try to build up the structural models hierarchy of Minimal Compound-Complex SentenceyesBelgorod State Universit

The economic efficiency of european football clubs - Data Envelopment Analysis (DEA) approach

The relevance of this paper lies in the fact that football business has grown significantly in the past 20 years and football clubs have become large companies, which in an effort to be profitable and successful on the field need to improve the efficiency of their business. The aim of this article is to measure economic efficiency of 48 big European football clubs and assess the relationship between efficiency and different financial and sportive indicators (variables). To measure efficiency, we used both widely used Data Envelopment Analysis (DEA) method and its extensions: DEA Super-efficiency and DEA Cross-efficiency models. The results showed that these methods can successively be applied to football clubs’ efficiency measurement and the analysis of the them can help to explain why some clubs are efficient or inefficient and which factors affects the efficiency. This paper will be interesting football clubs’ managers, football analytics, economists and other people interested in football business because we combine in it the most interesting ideas and methods about football clubs’ efficiency measurement. © 2016 Pyatunin et al

Issues of invention in the construction sector in conditions of its digitalization

The article considers the possibility of creating a digital environment of engineering creativity for organizing training for students of construction universities based on cloud technologies, which is an urgent task in the context of the implementation of the State program "Digital Economy of the Russian Federation". The purpose of the study is to develop theoretical grounds for creating a cloud digital environment of engineering creativity (DEEC) for interaction between participants in the creative process in construction universities. The practical value of the study lies in the possibility of applying the proposed solution when implementing distance learning for students of civil engineering universities