Estrategias didácticas para favorecer el aprendizaje en las carreras de Ingeniería utilizando tecnologías de información y comunicación (TICS)

En el proceso de formación de los estudiantes de carreras de ingeniería existe regularmente un índice considerable de reprobación y deserción. Se analizan los factores que inciden en esta problemática y se proponen distintas estrategias didácticas con TICs (Tecnologías para la Educación) para favorecer el proceso de enseñanza-aprendizaje en las materias de Física clásica. Se utilizó el software “Easy Java Simulations” (EJS) basado en applets para la creación de simulaciones discretas y facilitar un proceso de aprendizaje significativo de los conceptos matemáticos y físicos que constituyen la base de su carrera profesional. El uso de simuladores provocó en el estudiante su propia compresión acerca de los fenómenos y leyes físicas desarrollando una compresión de las relaciones entre conceptos físicos, variables y fenómenos

Drivers of and barriers to the SME internationalisation process in a small open economy

Small and medium-sized enterprises (SMEs) have actively increased their participation in international markets. This research's primary objective was to identify, based on 11 case studies, the main barriers to and drivers of the SME internationalisation process in a small open economy. Content analysis of in-depth interviews used Leximancer software to identify 7 themes that describe both internal and external barriers and 12 themes that characterise drivers, which were classified into five groups: SME human capital, technology, institutional support, networks and other drivers.info:eu-repo/semantics/publishedVersio

Early copper metallurgy in Northern Chile

The Central Andean region of South America has a long tradition of mining and metallurgy. Such activities were fundamental to the economic, socio-political and ideological dynamics of the pre-Columbian cultures that inhabited this area. In spite of their importance, few archaeological investigations of metallurgy have been carried out in the Central Andes in general, and in current Chilean territory in particular. The present project investigates archaeometallurgical sites in northern Chile using scientific analysis, as a first step towards a large-scale map of prehistoric copper production and exchange across South America. This research involves documentation and sampling of already excavated archaeological materials from a number of copper-producing sites located in the Atacama District. Preliminary results of XRF analysis of artefacts from the collection of the R. P. Gustavo Le Paige Archaeological Museum, San Pedro de Atacama, have been obtained and enabled us to characterise the different elements present in the metal objects. These results might provide information on the nature of the raw materials used

Diatom Proteomics Reveals Unique Acclimation Strategies to Mitigate Fe Limitation

Phytoplankton growth rates are limited by the supply of iron (Fe) in approximately one third of the open ocean, with major implications for carbon dioxide sequestration and carbon (C) biogeochemistry. To date, understanding how alteration of Fe supply changes phytoplankton physiology has focused on traditional metrics such as growth rate, elemental composition, and biophysical measurements such as photosynthetic competence (Fv/Fm). Researchers have subsequently employed transcriptomics to probe relationships between changes in Fe supply and phytoplankton physiology. Recently, studies have investigated longer-term (i.e. following acclimation) responses of phytoplankton to various Fe conditions. In the present study, the coastal diatom, Thalassiosira pseudonana, was acclimated (10 generations) to either low or high Fe conditions, i.e. Fe-limiting and Fe-replete. Quantitative proteomics and a newly developed proteomic profiling technique that identifies low abundance proteins were employed to examine the full complement of expressed proteins and consequently the metabolic pathways utilized by the diatom under the two Fe conditions. A total of 1850 proteins were confidently identified, nearly tripling previous identifications made from differential expression in diatoms. Given sufficient time to acclimate to Fe limitation, T. pseudonana up-regulates proteins involved in pathways associated with intracellular protein recycling, thereby decreasing dependence on extracellular nitrogen (N), C and Fe. The relative increase in the abundance of photorespiration and pentose phosphate pathway proteins reveal novel metabolic shifts, which create substrates that could support other well-established physiological responses, such as heavily silicified frustules observed for Fe-limited diatoms. Here, we discovered that proteins and hence pathways observed to be down-regulated in short-term Fe starvation studies are constitutively expressed when T. pseudonana is acclimated (i.e., nitrate and nitrite transporters, Photosystem II and Photosystem I complexes). Acclimation of the diatom to the desired Fe conditions and the comprehensive proteomic approach provides a more robust interpretation of this dynamic proteome than previous studies.This work was supported by National Science Foundation grants OCE1233014 (BLN) and the Office of Polar Programs Postdoctoral Fellowship grant 0444148 (BLN). DRG was supported by National Institutes of Health 5P30ES007033-10. AH and MTM were supported by Natural Sciences and Engineering Research Council of Canada. RFS and PWB were supported by the New Zealand Royal Society Marsden Fund and the Ministry of Science. This work is supported in part by the University of Washington's Proteomics Computer Resource Centre (UWPR95794). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

The fecal resistome of dairy cattle is associated with diet during nursing.

Antimicrobial resistance is a global public health concern, and livestock play a significant role in selecting for resistance and maintaining such reservoirs. Here we study the succession of dairy cattle resistome during early life using metagenomic sequencing, as well as the relationship between resistome, gut microbiota, and diet. In our dataset, the gut of dairy calves serves as a reservoir of 329 antimicrobial resistance genes (ARGs) presumably conferring resistance to 17 classes of antibiotics, and the abundance of ARGs declines gradually during nursing. ARGs appear to co-occur with antibacterial biocide or metal resistance genes. Colostrum is a potential source of ARGs observed in calves at day 2. The dynamic changes in the resistome are likely a result of gut microbiota assembly, which is closely associated with diet transition in dairy calves. Modifications in the resistome may be possible via early-life dietary interventions to reduce overall antimicrobial resistance