3,486 research outputs found
Simulation of Cosmic Ray neutrinos Interactions in Water
The program CORSIKA, usually used to simulate extensive cosmic ray air
showers, has been adapted to a water medium in order to study the acoustic
detection of ultra high energy neutrinos. Showers in water from incident
protons and from neutrinos have been generated and their properties are
described. The results obtained from CORSIKA are compared to those from other
available simulation programs such as Geant4.Comment: Talk presented on behalf of the ACoRNE Collaboration at the ARENA
Workshop 200
Tracking the evolution of multiple in vitro HCV replicon mutants under protease inhibitor selection pressure by 454 ultra deep sequencing.
TARGET: toward a solution for the readout electronics of the Cherenkov Telescope Array
TARGET is an application specific integrated circuit (ASIC) designed to read
out signals recorded by the photosensors in cameras of very-high-energy
gamma-ray telescopes exploiting the imaging of Cherenkov radiation from
atmospheric showers. TARGET capabilities include sampling at a high rate
(typically 1 GSample/s), digitization, and triggering on the sum of four
adjacent pixels. The small size, large number of channels read out per ASIC
(16), low cost per channel, and deep buffer for trigger latency (~16 s at
1 GSample/s) make TARGET ideally suited for the readout in systems with a large
number of telescopes instrumented with compact photosensors like multi-anode or
silicon photomultipliers combined with dual-mirror optics. The possible
advantages of such systems are better sensitivity, a larger field of view, and
improved angular resolution. The two latest generations of TARGET ASICs, TARGET
5 and TARGET 7, are soon to be used for the first time in two prototypes of
small-sized and medium-sized dual-mirror telescopes proposed in the framework
of the Cherenkov Telescope Array (CTA) project. In this contribution we report
on the performance of the TARGET ASICs and discuss future developments.Comment: 8 pages, 3 figures. In Proceedings of the 34th International Cosmic
Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions
at arXiv:1508.0589
Development of a SiPM Camera for a Schwarzschild-Couder Cherenkov Telescope for the Cherenkov Telescope Array
We present the development of a novel 11328 pixel silicon photomultiplier
(SiPM) camera for use with a ground-based Cherenkov telescope with
Schwarzschild-Couder optics as a possible medium-sized telescope for the
Cherenkov Telescope Array (CTA). The finely pixelated camera samples air-shower
images with more than twice the optical resolution of cameras that are used in
current Cherenkov telescopes. Advantages of the higher resolution will be a
better event reconstruction yielding improved background suppression and
angular resolution of the reconstructed gamma-ray events, which is crucial in
morphology studies of, for example, Galactic particle accelerators and the
search for gamma-ray halos around extragalactic sources. Packing such a large
number of pixels into an area of only half a square meter and having a fast
readout directly attached to the back of the sensors is a challenging task. For
the prototype camera development, SiPMs from Hamamatsu with through silicon via
(TSV) technology are used. We give a status report of the camera design and
highlight a number of technological advancements that made this development
possible.Comment: 8 pages, 5 figures, In Proceedings of the 34th International Cosmic
Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions
at arXiv:1508.0589
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles
Here, we identified release of extracellular vesicles (EVs) by the choroid plexus epithelium (CPE) as a new mechanism of blood-brain communication. Systemic inflammation induced an increase in EVs and associated pro-inflammatory miRNAs, including miR-146a and miR-155, in the CSF. Interestingly, this was associated with an increase in amount of multivesicular bodies (MVBs) and exosomes per MVB in the CPE cells. Additionally, we could mimic this using LPS-stimulated primary CPE cells and choroid plexus explants. These choroid plexus-derived EVs can enter the brain parenchyma and are taken up by astrocytes and microglia, inducing miRNA target repression and inflammatory gene up-regulation. Interestingly, this could be blocked in vivo by intracerebroventricular (icv) injection of an inhibitor of exosome production. Our data show that CPE cells sense and transmit information about the peripheral inflammatory status to the central nervous system (CNS) via the release of EVs into the CSF, which transfer this pro-inflammatory message to recipient brain cells. Additionally, we revealed that blockage of EV secretion decreases brain inflammation, which opens up new avenues to treat systemic inflammatory diseases such as sepsis
No observational constraints from hypothetical collisions of hypothetical dark halo primordial black holes with galactic objects
It was suggested by several authors that hypothetical primordial black holes
(PBHs) may contribute to the dark matter in our Galaxy. There are strong
constraints based on the Hawking evaporation that practically exclude PBHs with
masses m~1e15-1e16g and smaller as significant contributors to the Galactic
dark matter. Similarly, PBHs with masses greater than about 1e26g are
practically excluded by the gravitational lensing observation. The mass range
between 10e16g<m<10e26g is unconstrained. In this paper, we examine possible
observational signatures in the unexplored mass range, investigating
hypothetical collisions of PBHs with main sequence stars, red giants, white
dwarfs, and neutron stars in our Galaxy. This has previously been discussed as
possibly leading to an observable photon eruption due to shock production
during the encounter. We find that such collisions are either too rare to be
observed (if the PBH masses are typically larger than about 1e20g), or produce
too little power to be detected (if the masses are smaller than about 1e20g).Comment: Accepted for publication in The Astrophysical Journa
21. L’analyse des cancers de l’intervalle dans le dépistage du cancer du sein en Belgique : élaboration de la méthodologie et résultats
74. Mise en place et suivi du contrôle de qualité dans le cadre d’un programme organisé de dépistage du cancer du sein
The PANDA GEM-based TPC Prototype
We report on the development of a GEM-based TPC prototype for the PANDA
experiment. The design and requirements of this device will be illustrated,
with particular emphasis on the properties of the recently tested GEM-detector,
the characterization of the read-out electronics and the development of the
tracking software that allows to evaluate the GEM-TPC data.Comment: submitted to NIMA 4 pages, 6 picture
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