566 research outputs found

    Diploidy-based Genetic Algorithm in Nonstationary Environment

    Get PDF

    The PJSC “Novatek” activity efficiency reserves identification based on the economic and accounting analysis

    Get PDF
    A comparative analysis of three large Russian companies – PJSC “Novatek”, PJSC “Gazprom”, PJSC “Surgutneftegaz”, – is presented. The study relevance is caused by the gas industry strategic importance of the country as a whole as well as the specifics of its current situation: a large-scale drop of world gas prices, the ruble depreciation in relation to the US dollar, the introduction of sanctions on Russia. The financial and economic activities of the company PJSC “Novatek” is examined in the article. Various approaches to the analysis and identification of the company’s activities potential are studied. The investment attractiveness of competitors’ companies is evaluated. The research methodology included: complex, empirical, retrospective types of analysis (since the calculations of the companies’ financial conditions indicators are based on their consolidated financial statements data as of December 31, 2015); comparative, horizontal and vertical types of analysis; grouping method is categorization. As a result methodological principles of carrying out an economic analysis of gas producing companies’ activities are formed in order to make effective management decisions in conditions of risk and uncertainty

    Бренд работодателя как стратегия привлечения и удержания талантов

    Full text link
    Показана роль Службы по управлению человеческими ресурсами в создании бренда работодателя с целью привлечения и удержания талантливых сотрудников для создания эффективной организации в условиях жесткой конкурентной борьбы.Examines the role of Services in human resource management in employer branding to attract and retain talented employees to create effective organization in the conditions of rigid competitive struggle

    The main tasks of technical courses’ lecturers in forming future engineers’ technical mindset

    Full text link
    The article is devoted to examining the essence of technical mindset and the tasks the technical courses’ lecturers face in forming this mindset as a professionally important quality of future engineersВ статье рассматриваются сущность технического мышления и задачи, стоящие перед преподавателями технических дисциплин, по формированию данного вида мышления как профессионально важного качества будущих инженеро

    The role of podocytes dysfunction in chronic glomerulonephritis progression

    Get PDF
    In the review, the mechanisms of podocytes damage underlying the development of proteinuria and progression of glomerulosclerosis in chronic glomerulonephritis are discussed in detail. The results of experimental and clinical studies are presented. Under the different immune and non-immune factors the podocytes form a stereotyped response to damage consisting in the reorganization of the actin cytoskeleton, foot process effacement, the detachment of podocytes from the glomerular basement membrane, and the appearance of specific podocyte proteins and whole cells (podocyturia) in the urine. Massive podocyturia in a limited proliferative capacity of podocytes leads to reduce their total count in the glomerulus (podocytopenia) and the development of glomerulosclerosis. The authors describe the line of markers of the podocyte injury and invasive and non-invasive methods of their assessment. In addition, the relationship of podocyturia level with proteinuria and renal dysfunction are discussed, the prospects of assessment the podocyte proteins in urine for assessing of glomerular damage severity and glomerulosclerosis risk are examined

    Atypical Goodpasture’s disease: a clinical case report and literature review

    Get PDF
    Goodpasture’s disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease
    corecore