Development of a simple, self-contained flight test data acquisition system

A low cost flight test data acquisition system, applicable to general aviation airplanes, was developed which meets criteria for doing longitudinal and lateral stability analysis. Th package consists of (1) a microprocessor controller and data acquisition module; (2) a transducer module; and (3) a power supply module. The system is easy to install and occupies space in the cabin or baggage compartment of the airplane. All transducers are contained in these modules except the total pressure tube, static pressure air temperature transducer, and control position transducers. The NASA-developed MMLE program was placed on a microcomputer on which all data reduction is done. The flight testing program undertaken proved both the flight testing hardware and the data reduction method to be applicable to the current field of general aviation airplanes

Harnessing Rural Radio for Climate Change Mitigation and Adaptation in the Philippines

The working paper documents the pilot rural radio campaign, dubbed as 'Climate Change i-Broadkas Mo', implemented by the CGIAR Research Program on Climate Change, Agriculture and Food Security in Southeast Asia (CCAFS SEA) and the Philippine Federation of Rural Broadcasters (PFRB)​ in strategic regions of the Philippines from 2015 to 2018. The radio campaign provided PFRB affiliated broadcasters with scripts and ready-to-be-aired (RTBA) interviews on climate-smart agriculture. The lessons learned from the project can be used to enhance the capacities of rural broadcasters on climate change reporting and to create a demand for radio-based distance learning, not only in Northern Philippines, but in similar regions in Southeast Asia

Proteomic fingerprinting facilitates biodiversity assessments in understudied ecosystems: A case study on integrated taxonomy of deep sea copepods

Accurate and reliable biodiversity estimates of marine zooplankton are a prerequisite to understand how changes in diversity can affect whole ecosystems. Species identification in the deep sea is significantly impeded by high numbers of new species and decreasing numbers of taxonomic experts, hampering any assessment of biodiversity. We used in parallel morphological, genetic, and proteomic characteristics of specimens of calanoid copepods from the abyssal South Atlantic to test if proteomic fingerprinting can accelerate estimating biodiversity. We cross-validated the respective molecular discrimination methods with morphological identifications to establish COI and proteomic reference libraries, as they are a pre-requisite to assign taxonomic information to the identified molecular species clusters. Due to the high number of new species only 37% of the individuals could be assigned to species or genus level morphologically. COI sequencing was successful for 70% of the specimens analysed, while proteomic fingerprinting was successful for all specimens examined. Predicted species richness based on morphological and molecular methods was 42 morphospecies, 56 molecular operational taxonomic units (MOTUs) and 79 proteomic operational taxonomic units (POTUs), respectively. Species diversity was predicted based on proteomic profiles using hierarchical cluster analysis followed by application of the variance ratio criterion for identification of species clusters. It was comparable to species diversity calculated based on COI sequence distances. Less than 7% of specimens were misidentified by proteomic profiles when compared with COI derived MOTUs, indicating that unsupervised machine learning using solely proteomic data could be used for quickly assessing species diversity

Uveitis manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study.

The knowledge about risk factors for the onset of uveitis manifestations in patients with inflammatory bowel disease (IBD) is still limited. Here, we aimed to provide an overview of the clinical factors associated with the onset of uveitis in the Swiss IBD Cohort Study (SIBDCS). We included epidemiological and clinical data from 1840 patients with Crohn's disease (CD) and 1426 patients with ulcerative colitis (UC) followed up in the SIBDCS between 2006 and 2018. Associations between disease characteristics and uveitis were assessed in univariate and multivariate analyses. Overall, we identified 285 patients with uveitis. Uveitis was more frequent in patients with CD (11.1%; 205 of 1635) than UC (5.6%; 80 of 1346; odds ratio 2.11, p < 0.001). The occurrence of uveitis manifestations in patients with UC and CD was significantly associated with the onset of other extraintestinal manifestations, also in multivariate analyses. The onset of uveitis was associated with the hallmark features of severe disease in both CD and UC, including a higher clinical disease activity index and the use of immunomodulators or calcineurin inhibitors. In CD, uveitis was more frequent in females and showed a positive correlation with a positive family history of IBD. Our data demonstrate that uveitis in IBD occurs more often in CD as well as in women and is associated with a more severe disease course. This might guide physicians' awareness in at-risk patients to the presence of uveitis extraintestinal manifestations and help to improve patient care

Description of an advanced practice nursing consultative model to reduce restrictive siderail use in nursing homes

Researchers have demonstrated that the use of physical restraints in nursing homes can be reduced, particularly where advanced practice nurses (APNs) are utilized. We examined the link between APN practice, siderail reduction, and the costs of siderail alternatives in 273 residents in four Philadelphia nursing homes. The majority of participants were cognitively and physically impaired with multiple co-morbidities. APNs recommended a total of 1,275 siderail-alternative interventions aimed at reducing fall risk. The median cost of siderail alternatives to prevent falls per resident was $135. Residents with a fall history experienced a significantly higher cost of recommendation compared to non-fallers. Findings suggest that an APN consultation model can effectively be implemented through comprehensive, individualized assessment without incurring substantial costs to the nursing home. © 2007 Wiley Periodicals, Inc. Res Nurs Health 30: 131–140, 2007Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/56001/1/20185_ftp.pd

Model-based probabilistic frequent itemset mining

Data uncertainty is inherent in emerging applications such as location-based services, sensor monitoring systems, and data integration. To handle a large amount of imprecise information, uncertain databases have been recently developed. In this paper, we study how to efficiently discover frequent itemsets from large uncertain databases, interpreted under the Possible World Semantics. This is technically challenging, since an uncertain database induces an exponential number of possible worlds. To tackle this problem, we propose a novel methods to capture the itemset mining process as a probability distribution function taking two models into account: the Poisson distribution and the normal distribution. These model-based approaches extract frequent itemsets with a high degree of accuracy and support large databases. We apply our techniques to improve the performance of the algorithms for (1) finding itemsets whose frequentness probabilities are larger than some threshold and (2) mining itemsets with the {Mathematical expression} highest frequentness probabilities. Our approaches support both tuple and attribute uncertainty models, which are commonly used to represent uncertain databases. Extensive evaluation on real and synthetic datasets shows that our methods are highly accurate and four orders of magnitudes faster than previous approaches. In further theoretical and experimental studies, we give an intuition which model-based approach fits best to different types of data sets. © 2012 The Author(s).published_or_final_versio

UMF-078: A modified flubendazole with potent macrofilaricidal activity against Onchocerca ochengi in African cattle

<p>Abstract</p> <p>Background</p> <p>Human onchocerciasis or river blindness, caused by the filarial nematode <it>Onchocerca volvulus</it>, is currently controlled using the microfilaricidal drug, ivermectin. However, ivermectin does not kill adult <it>O. volvulus</it>, and in areas with less than 65% ivermectin coverage of the population, there is no effect on transmission. Therefore, there is still a need for a macrofilaricidal drug. Using the bovine filarial nematode <it>O. ochengi </it>(found naturally in African cattle), the macrofilaricidal efficacy of the modified flubendazole, UMF-078, was investigated.</p> <p>Methods</p> <p>Groups of 3 cows were treated with one of the following regimens: (a) a single dose of UMF-078 at 150 mg/kg intramuscularly (im), (b) 50 mg/kg im, (c) 150 mg/kg intraabomasally (ia), (d) 50 mg/kg ia, or (e) not treated (controls).</p> <p>Results</p> <p>After treatment at 150 mg/kg im, nodule diameter, worm motility and worm viability (as measured by metabolic reduction of tetrazolium to formazan) declined significantly compared with pre-treatment values and concurrent controls. There was abrogation of embryogenesis and death of all adult worms by 24 weeks post-treatment (pt). Animals treated at 50 mg/kg im showed a decline in nodule diameter together with abrogated reproduction, reduced motility, and lower metabolic activity in isolated worms, culminating in approximately 50% worm mortality by 52 weeks pt. Worms removed from animals treated ia were not killed, but exhibited a temporary embryotoxic effect which had waned by 12 weeks pt in the 50 mg/kg ia group and by 24 weeks pt in the 150 mg/kg ia group. These differences could be explained by the different absorption rates and elimination half-lives for each dose and route of administration.</p> <p>Conclusion</p> <p>Although we did not observe any signs of mammalian toxicity in this trial with a single dose, other studies have raised concerns regarding neuro- and genotoxicity. Consequently, further evaluation of this compound has been suspended. Nonetheless, these results validate the molecular target of the benzimidazoles as a promising lead for rational design of macrofilaricidal drugs.</p

Detailing radio frequency heating induced by coronary stents: a 7.0 tesla magnetic resonance study

The sensitivity gain of ultrahigh field Magnetic Resonance (UHF-MR) holds the promise to enhance spatial and temporal resolution. Such improvements could be beneficial for cardiovascular MR. However, intracoronary stents used for treatment of coronary artery disease are currently considered to be contra-indications for UHF-MR. The antenna effect induced by a stent together with RF wavelength shortening could increase local radiofrequency (RF) power deposition at 7.0 T and bears the potential to induce local heating, which might cause tissue damage. Realizing these constraints, this work examines RF heating effects of stents using electro-magnetic field (EMF) simulations and phantoms with properties that mimic myocardium. For this purpose, RF power deposition that exceeds the clinical limits was induced by a dedicated birdcage coil. Fiber optic probes and MR thermometry were applied for temperature monitoring using agarose phantoms containing copper tubes or coronary stents. The results demonstrate an agreement between RF heating induced temperature changes derived from EMF simulations versus MR thermometry. The birdcage coil tailored for RF heating was capable of irradiating power exceeding the specific-absorption rate (SAR) limits defined by the IEC guidelines by a factor of three. This setup afforded RF induced temperature changes up to +27 K in a reference phantom. The maximum extra temperature increase, induced by a copper tube or a coronary stent was less than 3 K. The coronary stents examined showed an RF heating behavior similar to a copper tube. Our results suggest that, if IEC guidelines for local/global SAR are followed, the extra RF heating induced in myocardial tissue by stents may not be significant versus the baseline heating induced by the energy deposited by a tailored cardiac transmit RF coil at 7.0 T, and may be smaller if not insignificant than the extra RF heating observed under the circumstances used in this study

September 11: Perspectives From the Field of Philanthropy -- Volume Three

Assesses the philanthropic sector's response to September 11 through interviews with leaders in the field. Provides lessons learned in the government-philanthropic relief effort, highlighting unresolved public policy issues. Includes recommendations