Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation.

Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, however, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients

A geometric bound on F-term inflation

We discuss a general bound on the possibility to realise inflation in any minimal supergravity with F-terms. The derivation crucially depends on the sGoldstini, the scalar field directions that are singled out by spontaneous supersymmetry breaking. The resulting bound involves both slow-roll parameters and the geometry of the K\"ahler manifold of the chiral scalars. We analyse the inflationary implications of this bound, and in particular discuss to what extent the requirements of single field and slow-roll can both be met in F-term inflation.Comment: 14 pages, improved analysis, references added, matches published versio

Effects of heavy modes on vacuum stability in supersymmetric theories

We study the effects induced by heavy fields on the masses of light fields in supersymmetric theories, under the assumption that the heavy mass scale is much higher than the supersymmetry breaking scale. We show that the square-masses of light scalar fields can get two different types of significant corrections when a heavy multiplet is integrated out. The first is an indirect level-repulsion effect, which may arise from heavy chiral multiplets and is always negative. The second is a direct coupling contribution, which may arise from heavy vector multiplets and can have any sign. We then apply these results to the sGoldstino mass and study the implications for the vacuum metastability condition. We find that the correction from heavy chiral multiplets is always negative and tends to compromise vacuum metastability, whereas the contribution from heavy vector multiplets is always positive and tends on the contrary to reinforce it. These two effects are controlled respectively by Yukawa couplings and gauge charges, which mix one heavy and two light fields respectively in the superpotential and the Kahler potential. Finally we also comment on similar effects induced in soft scalar masses when the heavy multiplets couple both to the visible and the hidden sector.Comment: LaTex, 24 pages, no figures; v2 some comments and references adde

Minimal Stability in Maximal Supergravity

Recently, it has been shown that maximal supergravity allows for non-supersymmetric AdS critical points that are perturbatively stable. We investigate this phenomenon of stability without supersymmetry from the sGoldstino point of view. In particular, we calculate the projection of the mass matrix onto the sGoldstino directions, and derive the necessary conditions for stability. Indeed we find a narrow window allowing for stable SUSY breaking points. As a by-product of our analysis, we find that it seems impossible to perturb supersymmetric critical points into non-supersymmetric ones: there is a minimal amount of SUSY breaking in maximal supergravity.Comment: 27 pages, 1 figure. v2: two typos corrected, published versio

A no-go for no-go theorems prohibiting cosmic acceleration in extra dimensional models

A four-dimensional effective theory that arises as the low-energy limit of some extra-dimensional model is constrained by the higher dimensional Einstein equations. Steinhardt & Wesley use this to show that accelerated expansion in our four large dimensions can only be transient in a large class of Kaluza-Klein models that satisfy the (higher dimensional) null energy condition [1]. We point out that these no-go theorems are based on a rather ad-hoc assumption on the metric, without which no strong statements can be made.Comment: 20 page

Metastable de Sitter vacua in N=2 to N=1 truncated supergravity

We study the possibility of achieving metastable de Sitter vacua in general N=2 to N=1 truncated supergravities without vector multiplets, and compare with the situations arising in N=2 theories with only hypermultiplets and N=1 theories with only chiral multiplets. In N=2 theories based on a quaternionic manifold and a graviphoton gauging, de Sitter vacua are necessarily unstable, as a result of the peculiar properties of the geometry. In N=1 theories based on a Kahler manifold and a superpotential, de Sitter vacua can instead be metastable provided the geometry satisfies some constraint and the superpotential can be freely adjusted. In N=2 to N=1 truncations, the crucial requirement is then that the tachyon of the mother theory be projected out from the daughter theory, so that the original unstable vacuum is projected to a metastable vacuum. We study the circumstances under which this may happen and derive general constraints for metastability on the geometry and the gauging. We then study in full detail the simplest case of quaternionic manifolds of dimension four with at least one isometry, for which there exists a general parametrization, and study two types of truncations defining Kahler submanifolds of dimension two. As an application, we finally discuss the case of the universal hypermultiplet of N=2 superstrings and its truncations to the dilaton chiral multiplet of N=1 superstrings. We argue that de Sitter vacua in such theories are necessarily unstable in weakly coupled situations, while they can in principle be metastable in strongly coupled regimes.Comment: 40 pages, no figure

Metastable supergravity vacua with F and D supersymmetry breaking

We study the conditions under which a generic supergravity model involving chiral and vector multiplets can admit viable metastable vacua with spontaneously broken supersymmetry and realistic cosmological constant. To do so, we impose that on the vacuum the scalar potential and all its first derivatives vanish, and derive a necessary condition for the matrix of its second derivatives to be positive definite. We study then the constraints set by the combination of the flatness condition needed for the tuning of the cosmological constant and the stability condition that is necessary to avoid unstable modes. We find that the existence of such a viable vacuum implies a condition involving the curvature tensor for the scalar geometry and the charge and mass matrices for the vector fields. Moreover, for given curvature, charges and masses satisfying this constraint, the vector of F and D auxiliary fields defining the Goldstino direction is constrained to lie within a certain domain. The effect of vector multiplets relative to chiral multiplets is maximal when the masses of the vector fields are comparable to the gravitino mass. When the masses are instead much larger or much smaller than the gravitino mass, the effect becomes small and translates into a correction to the effective curvature. We finally apply our results to some simple classes of examples, to illustrate their relevance.Comment: 40 pages; v2 some clarifications added in the introduction; v3 some typos correcte

Moduli stabilization with positive vacuum energy

We study the effect of anomalous U(1) gauge groups in string theory compactification with fluxes. We find that, in a gauge invariant formulation, consistent AdS vacua appear breaking spontaneously supergravity. Non vanishing D-terms from the anomalous symmetry act as an uplifting potential and could allow for de Sitter vacua. However, we show that in this case the gravitino is generically (but not always) much heavier than the electroweak scale. We show that alternative uplifting scheme based on corrections to the Kahler potential can be compatible with a gravitino mass in the TeV range.Comment: 20 pages, 1 figur

Scalar geometry and masses in Calabi-Yau string models

We study the geometry of the scalar manifolds emerging in the no-scale sector of Kahler moduli and matter fields in generic Calabi-Yau string compactifications, and describe its implications on scalar masses. We consider both heterotic and orientifold models and compare their characteristics. We start from a general formula for the Kahler potential as a function of the topological compactification data and study the structure of the curvature tensor. We then determine the conditions for the space to be symmetric and show that whenever this is the case the heterotic and the orientifold models give the same scalar manifold. We finally study the structure of scalar masses in this type of geometries, assuming that a generic superpotential triggers spontaneous supersymmetry breaking. We show in particular that their behavior crucially depends on the parameters controlling the departure of the geometry from the coset situation. We first investigate the average sGoldstino mass in the hidden sector and its sign, and study the implications on vacuum metastability and the mass of the lightest scalar. We next examine the soft scalar masses in the visible sector and their flavor structure, and study the possibility of realizing a mild form of sequestering relying on a global symmetry.Comment: 36 pages, no figure