Evidence for the reliability and validity, and some support for the practical utility of the two-factor Consideration of Future Consequences Scale-14

Researchers have proposed 1-factor, 2-factor, and bifactor solutions to the 12-item Consideration of Future Consequences Scale (CFCS-12). In order to overcome some measurement problems and to create a robust and conceptually useful two-factor scale the CFCS-12 was recently modified to include two new items and to become the CFCS-14. Using a University sample, we tested four competing models for the CFCS-14: (a) a 12-item unidimensional model, (b) a model fitted for two uncorrelated factors (CFC-Immediate and CFC-Future), (c) a model fitted for two correlated factors (CFC-I and CFC-F), and (d) a bifactor model. Results suggested that the addition of the two new items has strengthened the viability of a two factor solution of the CFCS-14. Results of linear regression models suggest that the CFC-F factor is redundant. Further studies using alcohol and mental health indicators are required to test this redundancy

The radial pulsation of AI Aurigae

We present an analysis of eleven years of Stromgren by photometry of the red semiregular variable star AI Aurigae. An early period determination of 63.9 days is confirmed by the long-term light curve behaviour. The light curve shows semi-regular changes with a mean period of 65 days reaching an amplitude of 0.6 mag in some cycles. The b-y colour changes perfectly parallel the V light curve, suggesting radial oscillation to be the main reason for the observed variations. We estimate the main characteristics of the star (mass, radius, effective temperature) that suggest radial pulsation in fundamental or first overtone mode.Comment: 7 pages, 3 figures, accepted for publication in A&

Total syntheses of conformationally-locked difluorinated pentopyranose analogues and a pentopyranosyl phosphate mimetic

Trifluoroethanol has been elaborated, via a telescoped sequence involving a metalated difluoroenol, a difluoroallylic alcohol, [2,3]-Wittig rearrangement, and ultimately an RCM reaction and requiring minimal intermediate purification, to a number of cyclooctenone intermediates. Epoxidation of these intermediates followed by transannular ring opening or dihydroxylation, then transannular hemiacetalization delivers novel bicyclic analogues of pentopyranoses, which were elaborated (in one case) to an analogue of a glycosyl phosphate

Drop deployment system for crystal growth apparatus

A crystal growth apparatus is presented. It utilizes a vapor diffusion method for growing protein crystals, and particularly such an apparatus wherein a ball mixer is used to mix the fluids that form a drop within which crystals are grown. Particular novelty of this invention lies in utilizing a ball mixer to completely mix the precipitate and protein solutions prior to forming the drop. Additional novelty lies in details of construction of the vials, the fluid deployment system, and the fluid storage system of the preferred embodiment

Direct Use of Low Enthalpy Deep Geothermal Resources in the East African Rift Valley

Geothermal energy is already harnessed across East Africa to provide hundreds of megawatts of electricity, with significant plans for future expansion towards generation at the gigawatt scale. This power generation utilizes the high steam temperatures (typically more than 200 °C) that are available in several locations in Kenya, Ethiopia and elsewhere. The presence of these high enthalpy resources has deflected attention from the often attractive low and medium enthalpy resources present across a more extensive portion of the region. Geothermally heated water at cooler temperatures (less than 90 °C) could be widely produced by drilling shallower and cheaper boreholes than those required for power production. This low enthalpy resource could be widely exploitable throughout the Rift Valley, offering a low carbon, sustainable, reliable and commercially competitive source of heating, drying and cooling (via absorption chillers) to local farmers and growers, and for low temperature commercial and industrial uses. Applications of this type would displace expensive fossil fuels, reducing costs and carbon emissions as well as improving the region’s energy and food security. The power input for pump systems can be accommodated by relatively small generators, so direct heat projects could be beneficial to consumers in areas with no grid access

The paralytic shellfish toxin profiles and global distribution of the dinoflagellate Alexandrium minutum Halim

A comprehensive review was undertaken of the distribution of the toxic dinoflagellate Alexandrium minutum Halim. The primary threat to humans caused by A. minutum is because of the production of paralytic shellfish toxins (PSTs) which can accumulate in seafood vectors, which if consumed lead to the human condition known as paralytic shellfish poisoning. Within this work it became apparent that the known global spread of this important species has increased, either due to range expansion, as a consequence of improved or novel investigation, or as a combination of these factors. Those populations of A. minutum capable of producing PSTs display a range of different toxin profiles with differing saxitoxin derivatives or differing proportions of common toxins being present. As yet no genetic basis for these differences in toxin productivity has been isolated although there are currently 4 recognised clades within the A. minutum species the two principle clades being the Pacific and the Global. A novel analysis of A. minutum toxin profiles was undertaken by applying K means clustering to PST profiles extracted from the literature. This analysis generated 5 distinctive clusters, each relating to a statistically separable toxin profile. Interestingly examples of each of the two major clades had representatives from different toxin profile clusters. This suggests further, currently undetermined genetic separation or relatedness between clades, as the differences in the ITS region of the ribosome upon which the clades are based, does not seem to be coupled to the specifics of the toxin profile. It also raises the possibility that there is an environmental driver for the differing toxin profiles, although profiles clustered geographically in some cases in others they were either cosmopolitan or spatially isolated. This new approach offers an additional tool with which to examine the relationships between populations and target further genetic research

Stereotactic Magnetic Resonance-guided Online Adaptive Radiotherapy for Oligometastatic Breast Cancer: A Case Report.

We present a case of durable local control achieved in a patient treated with stereotactic magnetic resonance-guided adaptive radiation therapy (SMART) for an abdominal lymph node in the setting of oligometastatic breast cancer. A 50-year-old woman with a history of triple positive metastatic invasive ductal carcinoma of the left breast, stage IV (T3N2M1), underwent neoadjuvant chemotherapy, mastectomy, adjuvant radiotherapy and maintenance hormonal treatment with HER2 targeted therapies. At 20 months after definitive treatment of her primary, imaging showed an isolated progressive enlargement of lymph nodes between hepatic segment V/IVB and the neck of the pancreas. Radiofrequency ablation was considered, however, this approach was decided not to be optimal due to the proximity to stomach, and pancreatic duct. The patient was treated with SMART for 40 Gray in 5 fractions. Two and a half years later, the patient remains without evidence of disease progression. She experienced Grade 2 acute and late toxicity that was successfully managed with medications. This experience shows that SMART is a feasible and effective treatment to control the abdominal oligometastatic disease for breast cancer

A Note on Warped String Compactification

We give a short review of a large class of warped string geometries, obtained via F-theory compactified on Calabi-Yau fourfolds, that upon reduction to 5 dimensions give consistent supersymmetric realizations of the RS compactification scenario.Comment: 11 pages, 3 figures; v3 corrected spelling of Calab