Aerothermal Performance of Shroudless Turbine Blade Tips with Relative Casing Movement Effects

Qualitatively different heat transfer characteristics between a transonic blade tip and a subsonic one have recently been discovered. High-resolution experimental data can be acquired for blade-tip heat transfer research using a high-speed linear cascade. A combined experimental and computational fluid dynamics study on several high-pressure turbine blade-tip configurations is conducted to understand the flow physics in both stationary and moving casing setups. Extensive tests measuring aerodynamic loss and heat transfer have been performed on a stationary squealer tip at engine-representative aerodynamic conditions. A systematic validation of the computational fluid dynamics solver (Rolls–Royce, plc. HYDRA code) is introduced, showing good agreement with the experimental data obtained. Relative casing movement effects are then evaluated for two tip configurations at three different tip gaps. The moving casing is shown to affect the aerothermal performance considerably; the trends are consistently captured for the large and medium tip gaps, both in the stationary and moving casing instances. Presented results confirm that, even with a moving casing, the blade tips remain transonic. It is also shown that the heat transfer is not only dependent on the tip gap size but also the tip-geometry configuration. The squealer cavity is subsonic regardless of the tip gap size, whereas the local flow state over a flat tip is much more responsive to tip gap size

Peer support for patients with type 2 diabetes: cluster randomised controlled trial

Objective To test the effectiveness of peer support for patients with type 2 diabetes

H1517+656: the Birth of a BL Lac Object?

H1517+656 is an unusual source, even for a BL Lac object. It is one of the most luminous BL Lacs known, with extreme emission properties at radio, optical, and X-ray frequencies. Furthermore, in our WFPC2 snapshot survey we discovered a series of peculiar arcs describing a 2.4 arcsec radius ring surrounding the source. This paper describes follow-up observations with additional WFPC2 bands and the STIS longpass filter, which have revealed this structure to be the remnants of a very recent galaxy merger. Population synthesis modelling has shown that regions of the arcs have stellar populations with age < 20 Myrs. Additionally, the circularity of the arcs indicates that the plane of the collision and hence accretion is very close to the plane of the sky. Given that BL Lac jets are thought to be aligned with the line of sight, this observation may provide a direct link between the transfer of angular momentum in an interaction and the generation of a radio source.Comment: 29 pages, 9 figures, accepted for publication in Ap

The Host Galaxies of Radio-Loud AGN: The Black Hole--Galaxy Connection

We have studied the host galaxies of a sample of radio-loud AGN spanning more than four decades in the energy output of the nucleus. The core sample includes 40 low-power sources (BL Lac objects) and 22 high-power sources (radio-loud quasars) spanning the redshift range z~0.15 to z~0.5, all imaged with the high spatial resolution of HST. All of the sources are found to lie in luminous elliptical galaxies, which follow the Kormendy relation for normal ellipticals. A very shallow trend is detected between nuclear brightness (corrected for beaming) and host galaxy luminosity. Black hole masses are estimated for the entire sample, using both the bulge luminosity--black hole mass and the velocity dispersion--black hole mass relations for local galaxies. The latter involves a new method, using the host galaxy morphological parameters, mu_e and r_e, to infer the velocity dispersion, sigma, via the fundamental plane correlation. Both methods indicate that the entire sample of radio-loud AGN are powered by very massive central black holes, with M_{black hole} ~ 10^8 to 10^10 M_{sun}$. Eddington ratios range from L/L_{Eddington} ~ 2 x 10^-4 to ~1, with the high- power sources having higher Eddington ratios than the low-power sources. Overall, radio-loud AGN appear to span a very large range in accretion efficiency, which is all but independent of the mass of the host galaxy.Comment: 21 pages, 5 figures. Accepted for publication in Ap

What is the Definition of Cure in Non-small Cell Lung Cancer?

The concept of cure from cancer is important to patients, but can be difficult to communicate in terms that are meaningful. This is because there are a number of definitions of cure that are applied by clinicians, patients and the public, and by policymakers that have a different meaning and significance. In this article, we provide a narrative review of the evidence concerning cure in lung cancer and show how the different definitions may apply in different settings. A better understanding of the various concepts of cure will improve communication with patients on this important topic. This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors

The HST Survey of BL Lacertae Objects. II. Host Galaxies

We have used the HST WFPC2 camera to survey 132 BL Lac objects comprising seven complete radio-, X-ray-, and optically-selected samples. We obtained useful images for 110 targets spanning the redshift range 0 < z < 1.3. In two thirds of the BL Lac images, host galaxies are detected, including nearly all for z < 0.5 (58 of 63). The highest redshift host galaxy detected is in a BL Lac object at z=0.664. In 58 of the 72 resolved host galaxies, a de Vaucouleurs profile is significantly preferred, at >99% confidence, over a pure exponential disk; the two fits are comparable in the remaining 14 cases. These results limit the number of disk systems to at most 8% of BL Lacs (at 99% confidence), and are consistent with all BL~Lac host galaxies being ellipticals. The detected host galaxies are luminous ellipticals with a median absolute K-corrected magnitude of M_R= -23.7 +- 0.6 mag, at least one magnitude brighter than M* and comparable to brightest cluster galaxies. The galaxy morphologies are generally smooth and undisturbed, with small or negligible ellipticities (<0.2). There is no correlation between host galaxy and observed nuclear magnitude or estimated jet power corrected for beaming. If black hole mass is correlated linearly with bulge mass in general, this implies a large range in Eddington ratio. Present data strongly support the unification picture with FR I galaxies constituting the bulk of the parent population of BL Lac objects.Comment: Accepted for publication on ApJ. 38 pages, 8 figure

Language and social/emotional problems identified at a universal developmental assessment at 30 months

Non peer reviewedPublisher PD

The effects of 12 weeks’ resistance training on psychological parameters and quality of life in adults with Facioscapulohumeral, Becker, and Limb–girdle dystrophies

Purpose Investigate the impact of 12-weeks’ moderate-intensity resistance training on psychological parameters in ambulatory adults with Facioscapulohumeral, Becker, and Limb–girdle muscular dystrophy. Methods Seventeen adults with Facioscapulohumeral (n = 6), Limb–girdle (n = 6; types 2A, 2B, 2L, and 2I), or Becker (n = 5) muscular dystrophy took part. Participants were tested at baseline (PRE), after a 12-week control period (PRE2), and after a 12-week supervised resistance training programme (POST). Training included multi-joint and single-joint resistance exercises. Outcomes from self-report questionnaires were health-related quality of life, depressive symptoms, trait anxiety, self-esteem, and physical self-worth. Results No difference in outcome measures, except depressive symptoms, was found in the control period (PRE to PRE2). Symptoms of depression were reduced by 9% from PRE to PRE2 (p < 0.05) and by a further 19% from PRE2 to POST (p < 0.05). Other changes from PRE2 to POST were that trait anxiety reduced by 10%, self-esteem increased by 10%, physical self-worth increased by 20%, and quality of life improved in 8 domains (p < 0.05). Conclusion These findings demonstrate the positive impact of moderate-intensity resistance training on psychological health and quality of life in adults with Facioscapulohumeral, Becker, and Limb–girdle muscular dystrophies. Implications for rehabilitation Resistance training can have a positive impact on psychological health and quality of life in adults with Facioscapulohumeral, Becker, and Limb–girdle muscular dystrophy. Healthcare professionals should consider including moderate-intensity resistance training within the management and treatment programmes of adults with Facioscapulohumeral, Becker, and Limb–girdle muscular dystrophy

Response of the Aerodyne Aerosol Mass Spectrometer to Inorganic Sulfates and Organosulfur Compounds: Applications in Field and Laboratory Measurements

Organosulfur compounds are important components of secondary organic aerosols (SOA). While the Aerodyne high-resolution time-of-flight aerosol mass spectrometer (AMS) has been extensively used in aerosol studies, the response of the AMS to organosulfur compounds is not well-understood. Here, we investigated the fragmentation patterns of organosulfurs and inorganic sulfates in the AMS, developed a method to deconvolve total sulfate into components of inorganic and organic origins, and applied this method in both laboratory and field measurements. Apportionment results from laboratory isoprene photooxidation experiment showed that with inorganic sulfate seed, sulfate functionality of organic origins can contribute ∼7% of SOA mass at peak growth. Results from measurements in the Southeastern U.S. showed that 4% of measured sulfate is from organosulfur compounds. Methanesulfonic acid was estimated for measurements in the coastal and remote marine boundary layer. We explored the application of this method to unit mass-resolution data, where it performed less well due to interferences. Our apportionment results demonstrate that organosulfur compounds could be a non-negligible source of sulfate fragments in AMS laboratory and field data sets. A reevaluation of previous AMS measurements over the full range of atmospheric conditions using this method could provide a global estimate/constraint on the contribution of organosulfur compounds

Overview of the international project on biogenic aerosol formation in the boreal forest (BIOFOR)

Aerosol formation and subsequent particle growth in ambient air have been frequently observed at a boreal forest site (SMEAR II station) in Southern Finland. The EU funded project BIOFOR (Biogenic aerosol formation in the boreal forest) has focused on: (a) determination of formation mechanisms of aerosol particles in the boreal forest site; (b) verification of emissions of secondary organic aerosols from the boreal forest site; and (c) quantification of the amount of condensable vapours produced in photochemical reactions of biogenic volatile organic compounds (BVOC) leading to aerosol formation. The approach of the project was to combine the continuous measurements with a number of intensive field studies. These field studies were organised in three periods, two of which were during the most intense particle production season and one during a non-event season. Although the exact formation route for 3 nm particles remains unclear, the results can be summarised as follows: Nucleation was always connected to Arctic or Polar air advecting over the site, giving conditions for a stable nocturnal boundary layer followed by a rapid formation and growth of a turbulent convective mixed layer closely followed by formation of new particles. The nucleation seems to occur in the mixed layer or entrainment zone. However two more prerequisites seem to be necessary. A certain threshold of high enough sulphuric acid and ammonia concentrations is probably needed as the number of newly formed particles was correlated with the product of the sulphuric acid production and the ammonia concentrations. No such correlation was found with the oxidation products of terpenes. The condensation sink, i.e., effective particle area, is probably of importance as no nucleation was observed at high values of the condensation sink. From measurement of the hygroscopic properties of the nucleation particles it was found that inorganic compounds and hygroscopic organic compounds contributed both to the particle growth during daytime while at night time organic compounds dominated. Emissions rates for several gaseous compounds was determined. Using four independent ways to estimate the amount of the condensable vapour needed for observed growth of aerosol particles we get an estimate of 2–10×107 vapour molecules cm−3. The estimations for source rate give 7.5–11×104 cm−3 s−1. These results lead to the following conclusions: The most probable formation mechanism is ternary nucleation (water-sulphuric acid-ammonia). After nucleation, growth into observable sizes (~3 nm) is required before new particles appear. The major part of this growth is probably due to condensation of organic vapours. However, there is lack of direct proof of this phenomenon because the composition of 1–5 nm size particles is extremely difficult to determine using the present state-of-art instrumentation