Atrophic Pancreatitis

Atrophic pancreatitis or chronic pancreatitis is probably more common in dogs than reports in the literature would indicate. It is possible that the disease is mis-diagnosed by many practitioners

Health assessment of elderly patients

BACKGROUND Comprehensive health assessment of the elderly in primary care will become a more important element of general practice as population aging proceeds and evidence of efficacy emerges. OBJECTIVE This article describes approaches to provision of health assessment in primary care based on the best available evidence. DISCUSSION Current best practice includes the use of structured health assessment protocols, an integrated multidisciplinary approach, targeting patient groups with intermediate levels of disability and handicap, in-home assessments and carefully structured follow up mechanisms.Len C Gray, Jonathan W Newbur

Monte Carlo Electron Trajectory Calculations of Electron Interactions in Samples with Special Geometries

Implementing a Monte Carlo simulation for application to electron sample interactions requires use of accurate treatments of elastic and inelastic scattering. In formulating a Monte Carlo simulation, careful testing must be carried out to ensure that the calculation yields sensible and useful results. A suitable testing procedure includes calculation of (1) electron backscatter coefficients as a function of atomic number, including any necessary adjustment of scattering parameters; (2) backscatter coefficients as a function of specimen tilt; (3) backscatter and transmission coefficients for thin foils; (4) backscattered electron energy distributions; (5) electron spatial distributions; and (6) x-rays, including x-ray depth distributions, and relative and absolute yields. Adapting a Monte Carlo simulation to a particular problem involving special sample geometry requires careful consideration of the interaction of the electron with the target. When the electron trajectory crosses a boundary, the segments of the trajectory in each phase must be calculated in a logical, stepwise fashion, allowing for modification of the step lengths due to variable scattering power in phases of different composition. The particular example of a planar boundary between phases of different composition is considered

RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1

Ribonucleases are critically important in many cellular and developmental processes and defects in their expression are associated with human disease. Pacman/XRN1 is a highly conserved cytoplasmic exoribonuclease which degrades RNAs in a 5' - 3' direction. In Drosophila, null mutations in pacman result in small imaginal discs, a delay in onset of pupariation and lethality during the early pupal stage. In this paper, we have used RNA-seq in a genome-wide search for mRNAs misregulated in pacman null wing imaginal discs. Only 4.2% of genes are misregulated ±>2-fold in pacman null mutants compared to controls, in line with previous work showing that Pacman has specificity for particular mRNAs. Further analysis of the most upregulated mRNAs showed that Pacman post-transcriptionally regulates the expression of the secreted insulin-like peptide Dilp8. Dilp8 is related to human IGF-1, and has been shown to co-ordinate tissue growth with developmental timing in Drosophila. The increased expression of Dilp8 is consistent with the developmental delay seen in pacman null mutants. Our analysis, together with our previous results, show that the normal role of this exoribonuclease in imaginal discs is to suppress the expression of transcripts that are crucial in apoptosis and growth control during normal development

The effects of sodium bicarbonate ingestion on swimming interval performance in trained competitive swimmers

The use of sodium bicarbonate (NaHCO) supplementation to improve repeated high-intensity performance is recommended; however, most swimming performance studies examine time trial efforts rather than repeated swims with interspersed recovery that are more indicative of training sessions. The aim of this study, therefore, was to investigate the effects of 0.3 g.kg BM NaHCO supplementation on sprint interval swimming (8 × 50 m) in regionally trained swimmers. Fourteen regionally competitive male swimmers (body mass (BM): 73 ± 8 kg) volunteered for this double-blind, randomised, crossover designed study. Each participant was asked to swim 8 × 50 m (front crawl) at a maximum intensity from a diving block, interspersed with 50 m active recovery swimming. After one familiarisation trial, this was repeated on two separate occasions whereby participants ingested either 0.3 g.kg BM NaHCO or 0.05 g.kg BM sodium chloride (placebo) in solution 60 min prior to exercise. Whilst there were no differences in time to complete between sprints 1-4 (p > 0.05), improvements were observed in sprint 5 (p = 0.011; ES = 0.26), 6 (p = 0.014; ES = 0.39), 7 (p = 0.005; ES = 0.60), and 8 (p = 0.004; ES = 0.79). Following NaHCO supplementation, pH was greater at 60 min (p < 0.001; ES = 3.09), whilst HCO was greater at 60 min (p < 0.001; ES = 3.23) and post-exercise (p = 0.016; ES = 0.53) compared to placebo. These findings suggest NaHCO supplementation can improve the latter stages of sprint interval swimming performance, which is likely due to the augmentation of pH and HCO prior to exercise and the subsequent increase in buffering capacity during exercise

Fundamental noise limitations to supercontinuum generation in microstructure fiber

Broadband noise on supercontinuum spectra generated in microstructure fiber is shown to lead to amplitude fluctuations as large as 50 % for certain input laser pulse parameters. We study this noise using both experimental measurements and numerical simulations with a generalized stochastic nonlinear Schroedinger equation, finding good quantitative agreement over a range of input pulse energies and chirp values. This noise is shown to arise from nonlinear amplification of two quantum noise inputs: the input pulse shot noise and the spontaneous Raman scattering down the fiber.Comment: 16 pages with 6 figure

"Ashkui" Vernal Ice-cover Phenomena and Their Ecological Role in Southern Labrador

This is the first documented incident of River Otter (Lutra canadensis) feeding on Common Goldeneye (Bucephala clangula) in a little studied region, southern Labrador. Our observations were made during spring staging when waterfowl aggregate at open water sites in frozen lakes and rivers, locally known as ashkui. We suggest that otters and raptors opportunistically forage on staging waterfowl at ashkui

The Dynamic Use of the Kawa Model: A Scoping Review

Background: The Kawa model, a framework to guide culturally relevant occupational therapy, has gained recognition and become more widely used in practice. Research on the model thus far, while still relatively sparse, provides guidance for the model’s use, including its strengths and facets that require further exploration to support its use and effectiveness in dynamic ways. Method: A scoping review was completed to gather, organize, appraise, and synthesize the current research evidence on use of the model. Results: Findings support the Kawa model’s culturally flexible application and its capacity to garner client-centered qualitative information, as well as to build therapeutic relationships in a variety of settings. Challenges to the model’s use include therapists’ inexperience limiting effectiveness and the need for additional quantitative assessment measures to supplement the qualitative findings gathered during use of the Kawa. Limitations to this review include author preconceptions, homogeneity among the authors, and inclusion of non-peer-reviewed theses. Conclusion: The Kawa model is an adaptable tool to examine and enhance well-being. It may be most effective when used by experienced therapists and in conjunction with other relevant tools. Further research is recommended to continue to evaluate its dynamic use

Moose, Alces alces, Winter Browse Use in Central Labrador

To determine the effect of forestry practices on the availability of winter Moose forage, we recorded Moose browse along four 250 m transects in each of five forest regeneration ages. Browse use was greater on 20- and 30-year-old regenerating stands as compared with recently clearcut stands (5 and 10 years old) or mature forest (&gt; 150 years old). Willow (Salix sp.) followed by White Birch (Betula papyrifera) had the highest proportion of browsing by Moose

The roles of the exoribonucleases DIS3L2 and XRN1 in disease

RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases which are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 have been well studied, less is known about their specific roles in development of multicellular organisms or human disease. This review focusses on the roles of DIS3L2 and XRN1 in the pathogenesis of human disease, particularly in relation to phenotypes seen in model organisms. The known diseases associated with loss of activity of DIS3L2 and XRN1 are discussed, together with possible mechanisms and cellular pathways leading to these disease conditions