New model for inorganic pollutants dissipation on the northern part of the romanian black sea coast

© 2018, Editura Academiei Romane. All rights reserved. Last decades, pollution became one of the significant issues worldwide. Atmospheric pollution has a negative impact on the population health, especially in the urban agglomeration, where the exceedance of the concentration limits of the toxic gases is recorded. Sulphur dioxide is the inorganic pollutants most spread in the atmosphere in industrial areas. One of these areas is situated in Northern part of the Romanian Black Sea Coast. Therefore, we aim at determining a model for SO2 dissipation, based on the data collected at six locations, as a function of the atmospheric variables

An unusual presentation of erythema multiforme in a paediatric patient

Background: Erythema multiforme (EM) is an acute, vesiculobullous disease of skin and mucous membranes with symptoms ranging from mild to severe. A complex interaction of different factors has been implicated the condition; the majority with a preceding herpes simplex infection. This report describes an unusual presentation of erythema multiforme affecting the lips and oral mucosa of a healthy 7-year-old boy in the form of lip adherence. Case report: Two weeks following eruption of oral ulcerations, a 7-year-old healthy boy developed severe erosive ulceration of both lips, causing complete lip adherence. This was accompanied by marked bilateral submandibular and cervical lymphadenopathy, tremor and sweating. Clinical and laboratory investigations led to a diagnosis of erythema multiforme. The patient was treated initially with gentle application of Vaseline between the lips using cotton buds in an attempt to release lip adhesion, followed by surgical release of the lips under general anaesthesia. Analgesics and topical steroid mouthwash were provided. Follow-up: Seven months later, the patient presented with a recurrence of his EM which included lesions on the skin. The patient was treated with antivirals, topical and systematic steroids to suppress the recurrent attacks of EM. Eighteen months following the initial presentation the patient and parent reported considerable decrease in the frequency, severity and duration of the occurrence of intra-oral ulcers, with no major episode of target lesions on the skin. Conclusion: Erythema multiforme is rare in children, however it should be considered in the differential diagnosis of recurrent erosive oral ulcerative lesions especially when the oral lesions resemble those of primary herpetic gingivostomatitis

Ethical considerations and challenges for using digital ethnography to research vulnerable populations

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.The social technologies of the web permit new techniques of research to emerge, often with novel ethical challenges. One such technique is digital ethnography. While there is a robust literature associated with digital approaches to ethnography, there is a lack of development in how digital ethnography can be used when researching vulnerable populations. This article seeks to clarify these methodological considerations, addressing the role of the researcher, data representation, and the ethical considerations necessary to research vulnerable consumers. We consider the various roles that digital ethnography can play in understanding emerging forms of social order in vulnerable consumer contexts, in generating social knowledge that is nuanced, participative, holistic, and practically orientated. We highlight a selection of the core issues concerning the use, practice and dissemination of digital ethnographic research available to social researchers, and how the incorporation of such methods can invigorate research on vulnerable consumers with new methodological innovations

Bi-allelic CAMSAP1 variants cause a clinically recognizable neuronal migration disorder

Non-centrosomal microtubules are essential cytoskeletal filaments that are important for neurite formation, axonal transport, and neuronal migration. They require stabilization by microtubule minus-end-targeting proteins including the CAMSAP family of molecules. Using exome sequencing on samples from five unrelated families, we show that bi-allelic CAMSAP1 loss-of-function variants cause a clinically recognizable, syndromic neuronal migration disorder. The cardinal clinical features of the syndrome include a characteristic craniofacial appearance, primary microcephaly, severe neurodevelopmental delay, cortical visual impairment, and seizures. The neuroradiological phenotype comprises a highly recognizable combination of classic lissencephaly with a posterior more severe than anterior gradient similar to PAFAH1B1(LIS1)-related lissencephaly and severe hypoplasia or absence of the corpus callosum; dysplasia of the basal ganglia, hippocampus, and midbrain; and cerebellar hypodysplasia, similar to the tubulinopathies, a group of monogenic tubulin-associated disorders of cortical dysgenesis. Neural cell rosette lineages derived from affected individuals displayed findings consistent with these phenotypes, including abnormal morphology, decreased cell proliferation, and neuronal differentiation. Camsap1-null mice displayed increased perinatal mortality, and RNAScope studies identified high expression levels in the brain throughout neurogenesis and in facial structures, consistent with the mouse and human neurodevelopmental and craniofacial phenotypes. Together our findings confirm a fundamental role of CAMSAP1 in neuronal migration and brain development and define bi-allelic variants as a cause of a clinically distinct neurodevelopmental disorder in humans and mice

The impact of direct‐acting antiviral agents on liver and kidney transplant costs and outcomes

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146297/1/ajt14895_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146297/2/ajt14895.pd

Center practice drives variation in choice of US kidney transplant induction therapy: a retrospective analysis of contemporary practice

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141776/1/tri13079_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141776/2/tri13079.pd

Characterization and prediction of permanent deformation properties of unbound granular materials for Pavement ME Design

The objective of this study is to characterize and predict the permanent deformation properties of unbound granular materials (UGMs) for Pavement ME Design. First, laboratory repeated load triaxial (RLT) tests are conducted on the UGMs from 11 quarries in Texas to measure the permanent strain curves. The shakedown theory is applied to evaluate the permanent deformation behavior of the selected UGMs. It is found that using Werkmeister's criteria to define the shakedown range boundaries is not suitable for the selected UGMs. Under this circumstance, new criteria are proposed to redefine the shakedown range boundaries for the flexible base materials in Texas. The new criteria are consistent with the current Texas flexible base specification in terms of aggregate classification. Second, the mechanistic-empirical design guide (MEPDG) model is used to determine the permanent deformation properties of the selected UGMs on the basis of the measured permanent strain curves. The determined permanent deformation properties are assigned as target values for the development of permanent deformation prediction models. Third, a series of performance-related base course properties are used to comprehensively characterize the UGMs, which include the dry density, moisture content, aggregate gradation, morphological properties, percent fines content, and methylene blue value. These performance-related base course properties are assigned as the inputs of the permanent deformation prediction models. Fourth, a multiple regression analysis is conducted to develop the prediction models for permanent deformation properties using these performance-related properties. The developed models are capable of accurately predicting the permanent deformation properties of UGMs. Compared to other prediction models (e.g., simple indicators-based models and Pavement ME Design models), the developed models have the highest prediction accuracy. It is also found that the Pavement ME model-predicted permanent strains are much lower than those measured from the RLT tests. This demonstrates that the current Pavement ME Design software substantially underestimates the rutting that occurs in base course. Finally, the developed prediction models are validated by comparing the predicted and measured permanent strains of other four base materials. The obtained R-squared value of 0.81 indicates that the developed models have a desirable accuracy in the prediction of permanent deformation properties of UGMs

Fabrication and Characterization of Electrospun Semiconductor Nanoparticle—Polyelectrolyte Ultra-Fine Fiber Composites for Sensing Applications

Fluorescent composite fibrous assembles of nanoparticle-polyelectrolyte fibers are useful multifunctional materials, utilized in filtration, sensing and tissue engineering applications, with the added benefits of improved mechanical, electrical or structural characteristics over the individual components. Composite fibrous mats were prepared by electrospinning aqueous solutions of 6 wt% poly(acrylic acid) (PAA) loaded with 0.15 and 0.20% v/v, carboxyl functionalized CdSe/ZnS nanoparticles (SNPs). The resulting fluorescent composite fibrous mats exhibits recoverable quenching when exposed to high humidity. The sensor response is sensitive to water concentration and is attributed to the change in the local charges around the SNPs due to deprotonation of the carboxylic acids on the SNPs and the surrounding polymer matrix