Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries

Hepatitis D virus (HDV) infection occurs as a coinfection with hepatitis B and increases the risk of hepatocellular carcinoma, decompensated cirrhosis, and mortality compared to hepatitis B virus (HBV) monoinfection. Reliable estimates of the prevalence of HDV infection and disease burden are essential to formulate strategies to find coinfected individuals more effectively and efficiently. The global prevalence of HBV infections was estimated to be 262,240,000 in 2021. Only 1,994,000 of the HBV infections were newly diagnosed in 2021, with more than half of the new diagnoses made in China. Our initial estimates indicated a much lower prevalence of HDV antibody (anti-HDV) and HDV RNA positivity than previously reported in published studies. Accurate estimates of HDV prevalence are needed. The most effective method to generate estimates of the prevalence of anti-HDV and HDV RNA positivity and to find undiagnosed individuals at the national level is to implement double reflex testing. This requires anti-HDV testing of all hepatitis B surface antigen-positive individuals and HDV RNA testing of all anti-HDV-positive individuals. This strategy is manageable for healthcare systems since the number of newly diagnosed HBV cases is low. At the global level, a comprehensive HDV screening strategy would require only 1,994,000 HDV antibody tests and less than 89,000 HDV PCR tests. Double reflex testing is the preferred strategy in countries with a low prevalence of HBV and those with a high prevalence of both HBV and HDV. For example, in the European Union and North America only 35,000 and 22,000 cases, respectively, will require anti-HDV testing annually

Walking Before You Can Run: The Knowledge, Networks, and Institutions for Emerging Market SMEs

Advancing the ability of emerging market small and medium size enterprises (SMEs) to learn, absorb new technologies, and grow is one of the greatest challenges in economic development and to theories of knowledge transfer. This chapter analyzes the mechanisms that can facilitate or impede the participation of Latin American SMEs in global value chains (GVCs), and in turn improve their capabilities and productivity. We attempt to shift the focus of attention that scholars and policy-makers have toward the types of knowledge and network linkages that emerging market SMEs need to sustainably benefit from GVCs. By drawing on recent work from the knowledge theory of the firm, development, and network dynamics, we call into question a core assumption about the necessary benefits that can accrue to SMEs by being tied more closely to sources of pioneering technologies. We argue instead that in order to overcome legacies of resource constraints and technology gaps, these SMEs need access to a variety of applied and experiential knowledge that help them transform their existing organizational capabilities into ones that enable them to implement basic international process and product standards, in turn allowing them to learn from potentially fruitful relationships in GVCs. Because of the way such knowledge is created, through intense interactions and exchanges of tacit knowledge, access is constrained. With a focus on the need for broad based upgrading of SME capabilities, we further suggest that particular constellations of interorganizational networks and public-private institutions, often overlooked in IB research, are best suited to facilitate such access

A carcinicultura do nordeste brasileiro e sua inserção em cadeias globais de produção: foco nos APLs do Ceará

O artigo faz uma análise da forma de inserção da carcinicultura do Nordeste, em particular dos Arranjos Produtivos Locais - APLs de cultivo de camarão do estado do Ceará, em cadeias globais de produção, bem como sua estrutura de governança. Isto porque os sistemas de cultivo destes crustáceos se concentram no Nordeste, sendo, na atualidade, o Ceará o maior produtor do Brasil na forma cultivado, expressando, ao longo de suas bacias hidrográficas, dois APLs bem característicos (litorais leste e oeste), que estiveram intensamente inseridos em mercado internacional por meio de cadeias globais de produção. O estudo teve por base um levantamento de dados secundários e entrevistas junto aos gestores e proprietários das empresas e outros agentes dos APLs. As principais evidências da pesquisa apontam que a inserção das empresas dos APLs ainda ocorre de forma dependente dos grandes compradores internacionais e os benefícios gerados, em grande parte, são apropriados fora da esfera produtiva, influenciando as capacitações produtivas e inovativas dos produtores locais. A estrutura de coordenação é verticalizada, demonstrado certo grau de assimetria nas relações de poder entre diferentes segmentos de agentes, sendo os principais estágios da cadeia de valor, em parte, controlados por agentes externos aos arranjos

A Vocation for Industrial Transformation: Ideology, Organizational Isomorphism, and Upgrading in the Guatemalan Sugar Industry

Between the late 1970s and the 2000s, the Guatemalan sugar industry transitioned from a production model with deplorable labor conditions and low productivity to a highly efficient model with improved conditions. This paper traces the origin and diffusion of this upgraded model to a small team of managers motivated by Elite Solidarism, an interpretation of the Vatican II Catholic Social Doctrine. It suggests that this ideology played the central causal role in this process of industrial transformation, as managers drew upon it to define the specific practices of the new model at one particular mill and then encouraged its diffusion

Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries

: Hepatitis D virus (HDV) infection occurs as a coinfection with hepatitis B and increases the risk of hepatocellular carcinoma, decompensated cirrhosis, and mortality compared to hepatitis B virus (HBV) monoinfection. Reliable estimates of the prevalence of HDV infection and disease burden are essential to formulate strategies to find coinfected individuals more effectively and efficiently. The global prevalence of HBV infections was estimated to be 262,240,000 in 2021. Only 1,994,000 of the HBV infections were newly diagnosed in 2021, with more than half of the new diagnoses made in China. Our initial estimates indicated a much lower prevalence of HDV antibody (anti-HDV) and HDV RNA positivity than previously reported in published studies. Accurate estimates of HDV prevalence are needed. The most effective method to generate estimates of the prevalence of anti-HDV and HDV RNA positivity and to find undiagnosed individuals at the national level is to implement double reflex testing. This requires anti-HDV testing of all hepatitis B surface antigen-positive individuals and HDV RNA testing of all anti-HDV-positive individuals. This strategy is manageable for healthcare systems since the number of newly diagnosed HBV cases is low. At the global level, a comprehensive HDV screening strategy would require only 1,994,000 HDV antibody tests and less than 89,000 HDV PCR tests. Double reflex testing is the preferred strategy in countries with a low prevalence of HBV and those with a high prevalence of both HBV and HDV. For example, in the European Union and North America only 35,000 and 22,000 cases, respectively, will require anti-HDV testing annually