A variational principle for volume-preserving dynamics

We provide a variational description of any Liouville (i.e. volume preserving) autonomous vector fields on a smooth manifold. This is obtained via a ``maximal degree'' variational principle; critical sections for this are integral manifolds for the Liouville vector field. We work in coordinates and provide explicit formulae

On the geometry of lambda-symmetries, and PDEs reduction

We give a geometrical characterization of $\lambda$-prolongations of vector fields, and hence of $\lambda$-symmetries of ODEs. This allows an extension to the case of PDEs and systems of PDEs; in this context the central object is a horizontal one-form $\mu$, and we speak of $\mu$-prolongations of vector fields and $\mu$-symmetries of PDEs. We show that these are as good as standard symmetries in providing symmetry reduction of PDEs and systems, and explicit invariant solutions

OpenCoesione and Monithon - a Transparency Effort

Context OpenCoesione is the first portal about the fulfilment of investments and projects planned by the Italian central government and by the Italian Regions using the 2007­2013 European Cohesion funds. Together with Monithon, it is a “transparency tool” whose aim is to foster participation of the citizens and efficiency of the public sector bodies in order to improve the implementation of development policies. By now it is one of the best Open Data portal in Italy quality­wise. Objective Our goal is to show the utility of these portals, how this open information is supposed to help the civil society and how data quality might affect reuse. Method We engage in the empirical observation on how data are exposed and used, discussing specific examples, and applying some data quality metrics. Results We present some evidences on how open data can positively affect the public sector bodies and the spending of funds. Conclusions Under­spending of EU Cohesion funds is a serious problem in Italy. OpenCoesione and Monithon can contribute solving this inefficiency, e.g., by presenting data in such a (standardised) way to enable their elaboration by third partie

Clutter and rainfall discrimination by means of doppler-polarimetric measurements and vertical reflectivity profile analysis

International audienceThe estimation of rainfall rate and other parameters from radar scattering volume is heavily affected by the presence of intense sea and ground clutter and echoes which appears in anomalous propagation condition. To deal with these non meteorological echoes we present a new clutter removal algorithm which combines the results of previous works. The algorithm fully exploits both the Doppler and polarimetric capabilities of the radar used and the analysis of vertical reflectivity profile in order to achieve the better identification of the meteorological and non-meteorological targets. The algorithm has been applied to the C-band radar of Monte Settepani (Savona, Italy), which runs in a high-topography environment. Preliminary results are presented

Clutter and rainfall discrimination by means of doppler-polarimetric measurements and vertical reflectivity profile analysis

The estimation of rainfall rate and other parameters from radar scattering volume is heavily affected by the presence of intense sea and ground clutter and echoes which appears in anomalous propagation condition. To deal with these non meteorological echoes we present a new clutter removal algorithm which combines the results of previous works. The algorithm fully exploits both the Doppler and polarimetric capabilities of the radar used and the analysis of vertical reflectivity profile in order to achieve the better identification of the meteorological and non-meteorological targets. The algorithm has been applied to the C-band radar of Monte Settepani (Savona, Italy), which runs in a high-topography environment. Preliminary results are presented

An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase

Phosphorylation of the activation loop is a fundamental step in the activation of most protein kinases. In the case of the Src tyrosine kinase, a prototypical kinase due to its role in cancer and its historic importance, phosphorylation of tyrosine 416 in the activation loop is known to rigidify the structure and contribute to the switch from the inactive to a fully active form. However, whether or not phosphorylation is able per-se to induce a fully active conformation, that efficiently binds ATP and phosphorylates the substrate, is less clear. Here we employ a combination of solution NMR and enhanced-sampling molecular dynamics simulations to fully map the effects of phosphorylation and ATP/ADP cofactor loading on the conformational landscape of Src tyrosine kinase. We find that both phosphorylation and cofactor binding are needed to induce a fully active conformation. What is more, we find a complex interplay between the A-loop and the hinge motion where the phosphorylation of the activation-loop has a significant allosteric effect on the dynamics of the C-lobe