4,753 research outputs found
Recommended from our members
A case of porphyria cutanea tarda in the setting of hepatitis C infection and tobacco usage
Porphyria cutanea tarda (PCT) is the most common type of porphyria, presenting in middle-aged patients with a photodistributed vesiculobullous eruption, milia, and scars. Porphyria cutanea tarda occurs in relation to inhibition of uroporphyrinogen decarboxylase, a key enzyme in the heme biosynthesis pathway. A number of genetic and acquired factors increase susceptibility to PCT by reducing uroporphyrinogen decarboxylase activity. A handful of other vesiculobullous conditions may mimic PCT both clinically and histologically; therefore, both skin biopsy and laboratory evaluation are helpful in confirming the diagnosis. We report a case of PCT in the setting of cigarette usage and untreated hepatitis C infection
Recommended from our members
Erythroderma with circulating atypical T-cells, likely Sézary syndrome
The erythrodermic patient is often challenging and requires careful evaluation. Work-up should include an extensive and careful medication history, histological and laboratory testing, and if necessary, molecular studies for the evaluation of underlying malignancy. Herein, we present an erythrodermic patient with repeated biopsies demonstrating a spongiotic process who was found to have circulating atypical T-cells concerning for an underlying erythrodermic T-cell leukemia, most closely related to Sézary syndrome
29-Day Analysis of Scale Heights and the Inference of the Topside Ionosphere over Millstone Hill during the 2002 Incoherent Scatter Radar Campaign
Ionospheric scale height is a measure of the topside altitude dependence of electron density and is a key ionospheric parameter due to its intrinsic connection to ionospheric dynamics, plasma temperature, and composition. A longtime problem has been that information on the bottomside ionospheric profile is readily available, but the observation of the topside ionosphere is still challenging. Despite numerous data techniques to characterize the topside ionosphere, the knowledge of the behavior of the topside ionosphere and its subsequent scale heights remains insufficient. The goal of this study is to evaluate whether or not we can characterize the topside ionospheric density and temperature profiles in the event that neither temperature nor electron density are measured by using a cost-effective method.
In a simple model, the electron density in the F-region topside decreases exponentially with height. This exponential decay is mainly driven by thermal diffusive equilibrium, but also dependent on the dominant ion species, as well as other drivers during nondiffusive conditions. A scale height based on observations of the temperature can generate topside electron density profiles. While a measure of the electron density profile enables a scale height to be inferred, hence yielding temperature information.
We found a new way to represent how much total electron content (TEC) is allotted for the topside ionosphere. We then used this information to successfully determine TEC using ionosonde data containing only bottomside electron density information. For the first time, slab thickness, which is directly proportional to scale height, was found to be correlated to the peak density height and introduced as a new index, k. Ultimately, k relates electron density parameters and can be a very useful tool for describing the topside ionosphere shape and subsequently, scale height. The methodology of using cost-effective, readily available ionosonde bottomside electron density data combined with GPS TEC was discovered to be capable of inferring the topside ionosphere. This was verified by incoherent scatter radar (ISR) data, though major issues surrounding the availability of ionogram data during nighttime hours greatly limited our study, especially during diffusive equilibrium conditions. Also, significant differences were found between ISR and ionosonde-determined peak density parameters, NmF2 and hmF2, and raised concerns in how the instruments were calibrated
- …