Extracorporeal CO2 removal in hypercapnic patients who fail noni nvasive ventialtion and refuse endotracheal intubation. a case series

Noninvasive ventilation (NIV) represents the standard of care for patients with exacerbation of chronic obstructive pulmonary disease. However, NIV fails in almost 40% of the most severe forms of acute hypercapnic respiratory failure and patients must undergo endotracheal intubation and invasive ventilation. Such transition from NIV to invasive ventilation is associated to increased mortality. Under these circumstances, patients may express a clear intention not to be intubated

Controlling the Er content of porous silicon using the doping current intensity

The results of an investigation on the Er doping of porous silicon are presented. Electrochemical impedance spectroscopy, optical reflectivity, and spatially resolved energy dispersive spectroscopy (EDS) coupled to scanning electron microscopy measurements were used to investigate on the transient during the first stages of constant current Er doping. Depending on the applied current intensity, the voltage transient displays two very different behaviors, signature of two different chemical processes. The measurements show that, for equal transferred charge and identical porous silicon (PSi) layers, the applied current intensity also influences the final Er content. An interpretative model is proposed in order to describe the two distinct chemical processes. The results can be useful for a better control over the doping process

A multilevel study of social networks and collective reactions to organizational change

The purpose of this study is to examine the micro-level dynamics underlying macro-level associations between organizational change and its outcomes, focusing in particular on the role of networks in shaping individual reactions to change. Drawing upon multilevel research on situational and individual antecedents of change, we first argue that the magnitude of change at the unit level has a nonlinear effect on change recipients' tendency to resist change, which in turn influences their adaptive behaviors. We argue, further, that the attitudinal and structural composition of the professional networks in which change recipients are embedded account for differences in their adaptive behaviors. Finally, we argue that individual adaptivity coalesces at the collective, that is, unit level, and predicts the attainment of desired change goals. We find general support for our arguments in a longitudinal study using multi-source data on 170 physicians in 29 units of a large hospital that experienced a major restructuring intervention. Results confirm that multilevel mechanisms involving individuals and their social context fundamentally undergird macro-level outcomes of change. We discuss the theoretical and practical implications of bringing a network perspective to bear on issues of individual and collective reactions to organizational change

Emotional intelligence, self-regulation, smartphone addiction: which relationship with student well-being and quality of life?

This study emphasizes the importance of analyzing factors that contribute to student well-being, as a result of the multiplicity of factors that can affect their quality of life (QoL). The literature indicates that, among these factors, emotional intelligence and self-regulation play a central role in influencing adolescents’ psychological and scholastic well-being. Technology is a fundamental aspect of adolescent life but addiction to the use of smartphones is increasing, which can affect both emotional intelligence and self-regulation, and in turn individual well-being and QoL. Therefore, this study explores the role of smartphone use with respect to these aspects. Participants were 215 Italian students attending middle school. By applying partial least squares structural equation modeling (PLS-SEM), the results confirm that self-regulation affects the QoL of students, but its role varies according to the degree of smartphone addiction. In conclusion, we confirm the relevance of the relationship between self-regulation and smartphone addiction in teaching students to be aware of their time spent using smartphones. Emotional intelligence and, in general, self-regulation should be encouraged to support the well-being and QoL of students in their adolescence at school

Effect of potential and chlorides on photoelectrochemical removal of diethyl phthalate from water

Removal of persistent pollutants from water by photoelectrocatalysis has emerged as a promising powerful process. Applied potential plays a key role in the photocatalytic activity of the semi-conductor as well as the possible presence of chloride ions in the solution. This work aims to investigate these effects on the photoelectrocatalytic oxidation of diethyl phthalate (DEP) by using TiO2 nanotubular anodes under solar light irradiation. PEC tests were performed at constant potentials under different concentration of NaCl. The process is able to remove DEP following a pseudo-first order kinetics: values of kapp of 1.25 × 10−3 min−1 and 1.56 × 10−4 min−1 have been obtained at applied potentials of 1.8 and 0.2 V, respectively. Results showed that, depending on the applied potential, the presence of chloride ions in the solution affects the degradation rate resulting in a negative effect: the presence of 500 mM of Cl− reduces the value of kapp by 50 and 80% at 0.2 and 1.8 V respectively

Metastability of solitary roll wave solutions of the St. Venant equations with viscosity

We study by a combination of numerical and analytical Evans function techniques the stability of solitary wave solutions of the St. Venant equations for viscous shallow-water flow down an incline, and related models. Our main result is to exhibit examples of metastable solitary waves for the St. Venant equations, with stable point spectrum indicating coherence of the wave profile but unstable essential spectrum indicating oscillatory convective instabilities shed in its wake. We propose a mechanism based on ``dynamic spectrum'' of the wave profile, by which a wave train of solitary pulses can stabilize each other by de-amplification of convective instabilities as they pass through successive waves. We present numerical time evolution studies supporting these conclusions, which bear also on the possibility of stable periodic solutions close to the homoclinic. For the closely related viscous Jin-Xin model, by contrast, for which the essential spectrum is stable, we show using the stability index of Gardner--Zumbrun that solitary wave pulses are always exponentially unstable, possessing point spectra with positive real part.Comment: 42 pages, 9 figure

Synergistic interactions between kainate and mGlu receptors regulate bouton Ca2+ signalling and mossy fibre LTP

It is currently unknown why glutamatergic presynaptic terminals express multiple types of glutamate receptors. We have addressed this question by studying both acute and long-term regulation of mossy fibre function in the hippocampus. We find that inhibition of both mGlu1 and mGlu5 receptors together can block the induction of mossy fibre LTP. Furthermore, mossy fibre LTP can be induced by the pharmacological activation of either mGlu1 or mGlu5 receptors, provided that kainate receptors are also stimulated. Like conventional mossy fibre LTP, chemically-induced mossy fibre LTP (chem-LTPm) depends on Ca2+ release from intracellular stores and the activation of PKA. Similar synergistic interactions between mGlu receptors and kainate receptors were observed at the level of Ca2+ signalling in individual giant mossy fibre boutons. Thus three distinct glutamate receptors interact, in both an AND and OR gate fashion, to regulate both immediate and long-term presynaptic function in the brain

How Much Can We Trust Major Element Quantification in Bioapatite Investigation?

Bioapatite is probably the key factor in the unreplicated success of vertebrates. Chemical data on bioapatite composition can be achieved on a solid sample by using different analytical tools such as spectroscopic and spectrometric methods. As analytical outputs can be affected by the physical-chemical characteristics of the sample matrix, an internal standard is usually required to correct and validate the results. Bioapatite lattice can accommodate iso- and heterovalent substitutions during life or diagenesis varying its chemical composition through (geological) time. If on the one hand, this makes bioapatite a unique archive of physical and chemical information for both the living cycle and the events occurring after death, on the other, it excludes the identification of a sole internal standard. Here, we propose a method to measure major element concentration with specific care for P, Ca, Mg, Na, K, Si, Al, and Fe, which are the main substituent atoms in bioapatite, through homemade matrix-matched external calibration standards for laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS). We tested the method on living and fossil shark teeth, critically comparing the results obtained using other analytical techniques and certified external standards. We demonstrated that matrix-matched calibration in LA-ICPMS is mandatory for obtaining a reliable chemical characterization even if factors such as matrix aggregation variability, diverse presence of volatile compounds, the fossilization footprint, and the instrumental variability can represent further variability parameters

Electrochemical synthesis of polyaniline/metal-based anodes and their use in microbial fuel cell

A limited number of metals may be suitable as bioanode material: noble metals, such as gold and platinum, could be the optimum choice being electrochemically inert in the operational potential window of the bioelectrochemical system. However, high costs limit their wide scale application. Even though its antimicrobial nature, copper is being considered as a promising alternative anode material, due to its high conductivity, that allows minimising the electrode material costs. Literature research indicated that high-performing electrochemically active biofilms may be grown on this metal. In the present work, gold and copper substrates have been coated by a conductive polymer (PANI), using a layer – by – layer procedure: surface grafting by reduction of 4-nitrobenzendiazonium salt was followed by reduction of nitro- to amino-groups; PANI was electrodeposited on this under-layer. The synthesized anodes were tested as working electrodes (WE) in a microbial fuel cell fed with anaerobic sludge and acetate; to assess the growth of the biofilm on the WE surface, the trend of the bioelectrocatalytic current of acetate oxidation was monitored over time. Cyclic voltammetries reveal the presence of typical redox couples related to the presence of electroactive microorganisms on the electrode surface. Preliminary data show bioelectrochemical activity on polyaniline-coated metal surfaces

Smartphone Distraction: Italian Validation of the Smartphone Distraction Scale (SDS)

This work aimed to validate the use of the Smartphone Distraction Scale (SDS) in Italy. The SDS was devised to assess distraction related to smartphone use in adult populations. A cross-sectional study was conducted among n = 609 adults (females = 76.4%; mean age = 30.26; SD age = 9.90). An assessment of the factorial structure of the Italian version was carried out using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). The four factors identified by Throuvala and colleagues were confirmed (i.e., attention impulsiveness, online vigilance, multitasking and emotion regulation). Reliability was assessed using Cronbach's alpha coefficient (0.703-0.889). The scale's scores showed significant linear correlations with validated instruments, including the Mobile Phone Problematic Use Scale (MPPUS)and the Cognitive Failures Questionnaire (CFQ). A multivariate analysis of variance showed significant differences in the means among participants belonging to different age groups (born before 1995 vs. born after 1996). In summary, the good psychometric properties observed led us to assume that this instrument can be applied and used in Italian studies to assess the cognitive dimension of distraction related to the use of smartphones