932 research outputs found

    The Truth in Compatibilism and the truth of Libertarianism

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    The paper offers the outlines of a response to the often-made suggestion is that it is impossible to see how indeterminism could possibly provide us with anything that we might want in the way of freedom, anything that could really amount to control, as opposed merely to an openness in the flow of reality that would constitute merely the injection of chance, or randomness, into the unfolding of the processes which underlie our activity. It is suggested that the best first move for the libertarian is to make a number of important concessions to the compatibilist. It should be conceded, in particular, that certain sorts of alternative possibilities are neither truly available to real, worldly agents, nor required in order that those agents should act freely; and it should be admitted also that it is the compatibilist who tends to give the most plausible sorts of analyses of many of the ‘can’ and ‘could have’ statements which seem to need to be assertible of those agents we regard as free. But these concessions do not bring compatibilism itself in their wake. The most promising version of libertarianism, it is argued, should be based on the idea that agency itself (and not merely some special instances of it which we might designate with the honorific appellation ‘free’) is inconsistent with determinism. This version of libertarianism, it is claimed, can avoid the objection that indeterminism is as difficult to square with true agential control as determinism can sometimes seem to be

    Judgment and the identity theory of truth

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    The identity theory of truth takes on different forms depending on whether it is combined with a dual relation or a multiple relation theory of judgment. This paper argues that there are two significant problems for the dual relation identity theorist regarding thought's answerability to reality, neither of which takes a grip on the multiple relation identity theory

    The linear tearing instability in three dimensional, toroidal gyrokinetic simulations

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    Linear gyro-kinetic simulations of the classical tearing mode in three-dimensional toroidal geometry were performed using the global gyro kinetic turbulence code, GKW . The results were benchmarked against a cylindrical ideal MHD and analytical theory calculations. The stability, growth rate and frequency of the mode were investigated by varying the current profile, collisionality and the pressure gradients. Both collision-less and semi-collisional tearing modes were found with a smooth transition between the two. A residual, finite, rotation frequency of the mode even in the absense of a pressure gradient is observed which is attributed to toroidal finite Larmor-radius effects. When a pressure gradient is present at low collisionality, the mode rotates at the expected electron diamagnetic frequency. However the island rotation reverses direction at high collisionality. The growth rate is found to follow a η1/7\eta^{1/7} scaling with collisional resistivity in the semi-collisional regime, closely following the semi-collisional scaling found by Fitzpatrick. The stability of the mode closely follows the stability using resistive MHD theory, however a modification due to toroidal coupling and pressure effects is seen

    Reducing the susceptibility of lumped-element KIDs to two-level system effects

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    Arrays of lumped-element kinetic inductance detectors (LEKIDs) optically coupled through an antenna-coupled transmission line are a promising candidate for future cosmic microwave background (CMB) experiments. However, the dielectric materials used for the microstrip architecture are known to degrade the performance of superconducting resonators. In this paper, we investigate the feasibility of microstrip coupling to a LEKID, focusing on a systematic study of the effect of depositing amorphous silicon-nitride on a LEKID. The discrete and spatially-separated inductive and capacitive regions of the LEKID allow us to vary the degree of dielectric coverage and determine the limitations of the microstrip coupling architecture. We show that by careful removal of dielectric from regions of high electric field in the capacitor, there is minimal degradation in dielectric loss tangent of a partially covered lumped-element resonator. We present the effects on the resonant frequency and noise power spectral density and, using the dark responsivity, provide an estimate for the resulting detector sensitivity.Comment: Presented at the 18th International Workshop on Low Temperature Detectors. Published in the Journal of Low Temperature Physic

    The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation.

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    An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important extra-hypothalamic functions, such as enhancing synaptic plasticity and hippocampal neurogenesis. The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation. The results revealed that peripheral treatment of rats with acyl-ghrelin enhanced both adult hippocampal neurogenesis and performance on SLR when measured 8-10 days after the end of acyl-ghrelin treatment. Our data show that systemic administration of physiological levels of acyl-ghrelin can produce long-lasting improvements in spatial memory that persist following the end of treatment. As ghrelin is potentially involved in regulating the relationship between metabolic and cognitive dysfunction in ageing and neurodegenerative disease, elucidating the underlying mechanisms holds promise for identifying novel therapeutic targets and modifiable lifestyle factors that may have beneficial effects on the brain.This work was supported by grants from the Medical Research Council (grant G0902250/94306), The Royal Society and the Biotechnology and Biological Sciences Research Council (grant BB/G019002/1).This is the final version. It was first published by Elsevier at http://www.sciencedirect.com/science/article/pii/S030645301400399

    The effect of elastic therapeutic taping on lumbar extensor isokinetic performance

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    Objective: To investigate the effects of elastic therapeutic tape when applied overlaying the lumbar extensors on different measures of muscle performance, compared to a placebo taping technique and a no-tape control. Relevance: Elastic therapeutic tape is frequently used as an adjunct to enhance athletic performance amongst athletes. However, limited research exists supporting its application on isokinetic performance of the lumbar extensor muscles. Methods: A cross-sectional experimental study. 21 participants received three taping conditions in a randomised order: elastic therapeutic tape, a placebo tape and a no-tape control. Peak torque, the time taken to reach peak torque and peak velocity were measured using an isokinetic dynamometer. Analysis: Friedman’s test and post-hoc Wilcoxon signed-rank test were used to determine the statistical differences between the three taping conditions. Level of significance was set at 0.05. Results: A statistically significant improvement in peak lumbar extensor torque was observed when comparing elastic therapeutic tape with the no-tape control (p 0.05). Conclusions: Results demonstrate that the application of elastic therapeutic tape overlaying the primary lumbar extensors significantly improves the maximal lumbar extension peak torque in healthy, asymptomatic adults

    Original paper Cell free DNA as a marker of training status in weightlifters

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    The purpose of this investigation was to elucidate the changes in cf-DNA as it relates to fluctuations in resistance training workloads and intensities. The relationship between cell free DNA (cf-DNA), C-reactive protein (CRP), creatine kinase (CK), testosterone (T), cortisol (C), testosterone-cortisol ratio (T:C), body mass and body composition were also examined. Eight weightlifters (5 males and 3 females, age = 25 ± 3.5 yr, body mass = 88.3 ± 22.7 kg, height = 173.8 ±8.4 cm) volunteered to participate in this study. Venous blood samples, body mass and body composition were taken six times, each corresponding to the end of a training phase. CK (p = 0.018, η² = 0.409) and CK %Δ (p \u3c 0.001, η² = 0.594) were the only biochemical variables to reach statistical significance at any point. A number of statistically significant correlations were found among variables. VLD4wk was related to CK %Δ (r = 0.86), VLD4wk %Δ was related CK %Δ (r = 0.86) and TID1wk was related to CRP (r = 0.83). cf-DNA %Δ was correlated with CRP and CRP %Δ (r = 0.83 and 0.86, respectively). CRP and CRP %Δ were correlated with BF % (r = 0.94 and 0.92, respectively). CK and CK %Δ were both related to T:C (r = 0.94 and 0.89, respectively) and T:C %Δ (r = 0.87 and 0.86, respectively). The correlation between cf-DNA and CRP suggests that cf-DNA may be a valuable indicator of inflammation in weightlifters
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