251 research outputs found
Acquistion Of Soft Skills And Affective Outcomes In Online Distance Education: A Secondary School Study
Supervisor:
Dr. Martha (Marti) Cleveland-Innes, PhDCanada is facing a shortage of workers skilled in affective outcomes, specifically soft skills. Some fingers are pointing to the primary and secondary institutions for failing to aptly prepare future employees with those skills. While these skills have been considered a part of the ‘hidden’ curriculum in the education of children, outcomes from our education curriculum, especially in primary and secondary schools, appears to not be meeting the soft skill requirements essential to today’s job market. While much literature explains the necessary inclusion of soft skill instruction in distance education, empirical evidence of its permeation and levels of success is limited. Is it possible to teach soft skill via distance educational media? If so, what practices accommodate them and how does this acquisition compare to traditional models of education? A mixed mode method was planned for the collection and analysis of data. Students within three Alberta school districts were invited to participate in this study; however, a lack of student involvement limited the quantifiable results collected from the six online distance education students. Six teachers were interviewed on their school’s policy and individual techniques teaching effective communication, working cooperatively in groups, acting responsibly, flexibility in learning, and creative problem-solving skills. Interviews were held with both online distance education and traditional school settings so that comparisons of methodology of soft skill teaching/modeling could be made. While soft skill teaching and practice is apparent in both types of educational settings, there appears to be a lack of continuity between school and the work force. That the online distance educational setting is effectively teaching the soft skills within the affective domain, with possibly greater degrees of success than their traditional counterparts. Comments and ideas by teachers and administrators are discussed along with possible explanations to be considered. Limitations to this study are also described with the recommendation of further studies into this Canadian problem
Attachment and couple sexual functioning
Within the last several years, there has been a surge in the publications that focus on attachment within the couple relationships, including how it pertains to infidelity treatment. Despite the interest in couple relationships and attachment, however, a limited amount of literature focuses on how varying styles of attachment manifest in a couple\u27s level of sexual functioning. This study is a response to the need to explore the literature and related gaps in literature
Casimir force between sharp-shaped conductors
Casimir forces between conductors at the sub-micron scale cannot be ignored
in the design and operation of micro-electromechanical (MEM) devices. However,
these forces depend non-trivially on geometry, and existing formulae and
approximations cannot deal with realistic micro-machinery components with sharp
edges and tips. Here, we employ a novel approach to electromagnetic scattering,
appropriate to perfect conductors with sharp edges and tips, specifically to
wedges and cones. The interaction of these objects with a metal plate (and
among themselves) is then computed systematically by a multiple-scattering
series. For the wedge, we obtain analytical expressions for the interaction
with a plate, as functions of opening angle and tilt, which should provide a
particularly useful tool for the design of MEMs. Our result for the Casimir
interactions between conducting cones and plates applies directly to the force
on the tip of a scanning tunneling probe; the unexpectedly large temperature
dependence of the force in these configurations should attract immediate
experimental interest
Tunability of Critical Casimir Interactions by Boundary Conditions
We experimentally demonstrate that critical Casimir forces in colloidal
systems can be continuously tuned by the choice of boundary conditions. The
interaction potential of a colloidal particle in a mixture of water and
2,6-lutidine has been measured above a substrate with a gradient in its
preferential adsorption properties for the mixture's components. We find that
the interaction potentials at constant temperature but different positions
relative to the gradient continuously change from attraction to repulsion. This
demonstrates that critical Casimir forces respond not only to minute
temperature changes but also to small changes in the surface properties.Comment: 4 figures;
http://www.iop.org/EJ/article/0295-5075/88/2/26001/epl_88_2_26001.htm
Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila
Recent work in several model organisms has revealed that apoptotic cells are able to stimulate neighboring surviving cells to undergo additional proliferation, a phenomenon termed apoptosis-induced proliferation. This process depends critically on apoptotic caspases such as Dronc, the Caspase-9 ortholog in Drosophila, and may have important implications for tumorigenesis. While it is known that Dronc can induce the activity of Jun N-terminal kinase (JNK) for apoptosis-induced proliferation, the mechanistic details of this activation are largely unknown. It is also controversial if JNK activity occurs in dying or in surviving cells. Signaling molecules of the Wnt and BMP families have been implicated in apoptosis-induced proliferation, but it is unclear if they are the only ones. To address these questions, we have developed an efficient assay for screening and identification of genes that regulate or mediate apoptosis-induced proliferation. We have identified a subset of genes acting upstream of JNK activity including Rho1. We also demonstrate that JNK activation occurs both in apoptotic cells as well as in neighboring surviving cells. In a genetic screen, we identified signaling by the EGFR pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling. These data underscore the importance of genetic screening and promise an improved understanding of the mechanisms of apoptosis-induced proliferation
Recommended from our members
The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia.
The study of long noncoding RNAs (lncRNAs) is an emerging area of cancer research, in part due to their ability to serve as disease biomarkers. However, few studies have investigated lncRNAs in chronic lymphocytic leukemia (CLL). We have identified one particular lncRNA, treRNA, which is overexpressed in CLL B-cells. We measured transcript expression in 144 CLL patient samples and separated samples into high or low expression of treRNA relative to the overall median. We found that high expression of treRNA is significantly associated with shorter time to treatment. High treRNA also correlates with poor prognostic indicators such as unmutated IGHV and high ZAP70 protein expression. We validated these initial findings in samples collected in a clinical trial comparing the nucleoside analog fludarabine alone or in combination with the alkylating agent cyclophosphamide in untreated CLL samples collected prior to starting therapy (E2997). High expression of treRNA was independently prognostic for shorter progression free survival in patients receiving fludarabine plus cyclophosphamide. Given these results, in order to study the role of treRNA in DNA damage response we generated a model cell line system where treRNA was over-expressed in the human B-CLL cell line OSU-CLL. Relative to the vector control line, there was less cell death in OSU-CLL over-expressing treRNA after exposure to fludarabine and mafosfamide, due in part to a reduction in DNA damage. Therefore, we suggest that treRNA is a novel biomarker in CLL associated with aggressive disease and poor response to chemotherapy through enhanced protection against cytotoxic mediated DNA damage
Critical Casimir effect in classical binary liquid mixtures
If a fluctuating medium is confined, the ensuing perturbation of its
fluctuation spectrum generates Casimir-like effective forces acting on its
confining surfaces. Near a continuous phase transition of such a medium the
corresponding order parameter fluctuations occur on all length scales and
therefore close to the critical point this effect acquires a universal
character, i.e., to a large extent it is independent of the microscopic details
of the actual system. Accordingly it can be calculated theoretically by
studying suitable representative model systems.
We report on the direct measurement of critical Casimir forces by total
internal reflection microscopy (TIRM), with femto-Newton resolution. The
corresponding potentials are determined for individual colloidal particles
floating above a substrate under the action of the critical thermal noise in
the solvent medium, constituted by a binary liquid mixture of water and
2,6-lutidine near its lower consolute point. Depending on the relative
adsorption preferences of the colloid and substrate surfaces with respect to
the two components of the binary liquid mixture, we observe that, upon
approaching the critical point of the solvent, attractive or repulsive forces
emerge and supersede those prevailing away from it. Based on the knowledge of
the critical Casimir forces acting in film geometries within the Ising
universality class and with equal or opposing boundary conditions, we provide
the corresponding theoretical predictions for the sphere-planar wall geometry
of the experiment. The experimental data for the effective potential can be
interpreted consistently in terms of these predictions and a remarkable
quantitative agreement is observed.Comment: 30 pages, 17 figure
Normal and lateral critical Casimir forces between colloids and patterned substrates
We study the normal and lateral effective critical Casimir forces acting on a
spherical colloid immersed in a critical binary solvent and close to a
chemically structured substrate with alternating adsorption preference. We
calculate the universal scaling function for the corresponding potential and
compare our results with recent experimental data [Soyka F., Zvyagolskaya O.,
Hertlein C., Helden L., and Bechinger C., Phys. Rev. Lett., 101, 208301
(2008)]. The experimental potentials are properly captured by our predictions
only by accounting for geometrical details of the substrate pattern for which,
according to our theory, critical Casimir forces turn out to be a sensitive
probe.Comment: 6 pages, 3 figure
Phase separation transition in liquids and polymers induced by electric field gradients
Spatially uniform electric fields have been used to induce instabilities in
liquids and polymers, and to orient and deform ordered phases of
block-copolymers. Here we discuss the demixing phase transition occurring in
liquid mixtures when they are subject to spatially nonuniform fields. Above the
critical value of potential, a phase-separation transition occurs, and two
coexisting phases appear separated by a sharp interface. Analytical and
numerical composition profiles are given, and the interface location as a
function of charge or voltage is found. The possible influence of demixing on
the stability of suspensions and on inter-colloid interaction is discussed.Comment: 7 pages, 3 figures. Special issue of the J. Phys. Soc. Ja
Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides
This is the final version of the article. Available from the publisher via the DOI in this record.The impact of neonicotinoid insecticides on the health of bee pollinators is a topic of intensive research and considerable current debate [1]. As insecticides, certain neonicotinoids, i.e., N-nitroguanidine compounds such as imidacloprid and thiamethoxam, are as intrinsically toxic to bees as to the insect pests they target. However, this is not the case for all neonicotinoids, with honeybees orders of magnitude less sensitive to N-cyanoamidine compounds such as thiacloprid [2]. Although previous work has suggested that this is due to rapid metabolism of these compounds [2, 3, 4, 5], the specific gene(s) or enzyme(s) involved remain unknown. Here, we show that the sensitivity of the two most economically important bee species to neonicotinoids is determined by cytochrome P450s of the CYP9Q subfamily. Radioligand binding and inhibitor assays showed that variation in honeybee sensitivity to N-nitroguanidine and N-cyanoamidine neonicotinoids does not reside in differences in their affinity for the receptor but rather in divergent metabolism by P450s. Functional expression of the entire CYP3 clade of P450s from honeybees identified a single P450, CYP9Q3, that metabolizes thiacloprid with high efficiency but has little activity against imidacloprid. We demonstrate that bumble bees also exhibit profound differences in their sensitivity to different neonicotinoids, and we identify CYP9Q4 as a functional ortholog of honeybee CYP9Q3 and a key metabolic determinant of neonicotinoid sensitivity in this species. Our results demonstrate that bee pollinators are equipped with biochemical defense systems that define their sensitivity to insecticides and this knowledge can be leveraged to safeguard bee health.his study received funding from Bayer AG. C.B. received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 646625 ). C.B. and K.B. received funding from Biotechnology and Biological Sciences Research Council (BBSRC, award number 15076182 ). The work at Rothamsted forms part of the Smart Crop Protection (SCP) strategic programme ( BBS/OS/CP/000001 ) funded through the Biotechnology and Biological Sciences Research Council’s Industrial Strategy Challenge Fund
- …