Tuning of Adaptive Weight Depth Map Generation Algorithms Exploratory Data Analysis and Design of Computer Experiments (DOCE)

In depth map generation algorithms, parameters settings to yield an accurate disparity map estimation are usually chosen empirically or based on un planned experiments -- Algorithms' performance is measured based on the distance of the algorithm results vs. the Ground Truth by Middlebury's standards -- This work shows a systematic statistical approach including exploratory data analyses on over 14000 images and designs of experiments using 31 depth maps to measure the relative inf uence of the parameters and to fine-tune them based on the number of bad pixels -- The implemented methodology improves the performance of adaptive weight based dense depth map algorithms -- As a result, the algorithm improves from 16.78% to 14.48% bad pixels using a classical exploratory data analysis of over 14000 existing images, while using designs of computer experiments with 31 runs yielded an even better performance by lowering bad pixels from 16.78% to 13

Low oxygen tension primes aortic endothelial cells to the reparative effect of tissue-protective cytokines

Erythropoietin (EPO) has both erythropoietic and tissue-protective properties. The EPO analogues carbamylated EPO (CEPO) and pyroglutamate helix B surface peptide (pHBSP) lack the erythropoietic activity of EPO but retain the tissue-protective properties that are mediated by a heterocomplex of EPO receptor (EPOR) and the β common receptor (βCR). We studied the action of EPO and its analogues in a model of wound healing where a bovine aortic endothelial cells (BAECs) monolayer was scratched and the scratch closure was assessed over 24 h under different oxygen concentrations. We related the effects of EPO and its analogues on repair to their effect on BAECs proliferation and migration (evaluated using a micro-Boyden chamber). EPO, CEPO and pHBSP enhanced scratch closure only at lower oxygen (5%), while their effect at atmospheric oxygen (21%) was not significant. The mRNA expression of EPOR was doubled in 5% compared to 21% oxygen, and this was associated with increased EPOR assessed by immunofluorescence and Western blot. By contrast βCR mRNA levels were similar in 5% and 21% oxygen. EPO and its analogues increased both BAECs proliferation and migration, suggesting that both may be involved in the reparative process. The priming effect of low oxygen tension on the action of tissue-protective cytokines may be of relevance to vascular disease, including atherogenesis and restenosis

Proteomic Changes of Alveolar Lining Fluid in Illnesses Associated with Exposure to Inhaled Non-Infectious Microbial Particles

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