Basic operations and preliminary results on the growth and survival rates of tench (Tinca tinca L.) and lettuce (Lactuca sativa L.) in an aquaponic prototype

Este trabajo presenta el manejo básico de un prototipo acuapónico así como resultados preliminares sobre el crecimiento de tencas y lechugas en dicho prototipo. El sistema consta de una instalación de recirculación de agua con cuatro elementos en el siguiente orden de dirección del agua: depósito de peces, del que parten dos ramas: una de ellas hacia un biofiltro, zona de hidropónicos en NFT (“Nutrient Film Technique”) y colector; y la otra hacia la zona de hidropónicos en raíz flotante, que desemboca igualmente en el colector. Los resultados obtenidos durante 66 días de ensayo, criando las tencas a densidades entre 0,68 kg/m3 y 1,19 kg/m3, con raciones diarias entre el 0,8 y 1,23% de la biomasa, un volumen total de la instalación de 2.800 litros con tasa media diaria de recambio de agua del 1,26% y parámetros variables de la misma, con máximos y mínimos, respectivamente, de temperaturas, entre 15 y 25ºC; de nitratos, entre 32 y 105 ppm; y de pH entre 7,3 y 8,25, muestran una elevada supervivencia de las tencas (99,32%) y las lechugas (98%); y la finalización del ciclo de estas últimas alcanzando tamaños comerciales. El control de los parámetros citados, más los niveles de oxígeno, y una instalación sencilla de baja densidad de peces sin dispositivos de separación de sólidos, permitió la regulación óptima del sistema.This paper presents the basic operations of an aquaponic prototype and preliminary results on the growth of tench and lettuce. This prototype consisting in a water recirculating system made up of: fish rearing tank with two outlet pipes, one of this connected to a biofilter, NFT hydroponics device and sump; and the other one, to a raft hydroponic device draining to the same sump. Results showed a high survival rate of tenchs (99,32%) and lettuces (98%), and finalization of vegetative cycle of lettuce with commercial sizes, under the following assay conditions: tench stock densities between 0,68 kg/m3 and 1,19 kg/m3, with daily food rates between 0,88 y 1,23% of fishes biomass, a total system water volume of 2,8 m3 and 1,26% of water reposition daily rate, and water variables parameters between 15 and 25ºC temperature; 32 and 105 ppm of nitrate levels; and 8,25 and 7,3 pH values. Control of the above mentioned parameters, plus oxygen levels in water, maintaining fish at low densities and without solids removal devices, reached the optimum regulation syste

Rapid Decreasing in the Orbital Period of the Detached White Dwarf?main Sequence Binary SDSS J143547.87+373338.5

SDSS J143547.87+373338.5 is a detached eclipsing binary that contains a white dwarf with a mass of 0.5 M⊙ and a fully convective star with a mass of 0.21 M⊙. The eclipsing binary was monitored photometrically from 2009 March 24 to 2015 April 10, by using two 2.4-m telescopes in China and in Thailand. The changes in the orbital period are analyzed based on eight newly determined eclipse times together with those compiled from the literature. It is found that the observed?calculated (O?C) diagram shows a downward parabolic change that reveals a continuous period decrease at a rate of dot{P}=-8.04× {10}-11 s s‑1. According to the standard theory of cataclysmic variables, angular momentum loss (AML) via magnetic braking (MB) is stopped for fully convective stars. However, this period decrease is too large to be caused by AML via gravitational radiation (GR), indicating that there could be some extra source of AML beyond GR, but the predicted mass-loss rates from MB seem unrealistically large. The other possibility is that the O?C diagram may show a cyclic oscillation with a period of 7.72 years and a small amplitude of 0.ͩ000525. The cyclic change can be explained as the light-travel-time effect via the presence of a third body because the required energy for the magnetic activity cycle is much larger than that radiated from the secondary in a whole cycle. The mass of the potential third body is determined to be {M}3{sin}{i}prime =0.0189(+/- 0.0016) M⊙ when a total mass of 0.71 M⊙ for SDSS J143547.87+373338.5 is adopted. For orbital inclinations {i}prime ≥slant 15uildrel{circ}over{.} 9, it would be below the stable hydrogen-burning limit of M3 ∼ 0.072 M⊙, and thus the third body would be a brown dwarf.Fil: Qian, S. B.. Chinese Academy of Sciences; República de ChinaFil: Han, Z. T.. Chinese Academy of Sciences; República de ChinaFil: Soonthornthum, B.. National Astronomical Research Institute of Thailand; TailandiaFil: Zhu, L. Y.. Chinese Academy of Sciences; República de ChinaFil: He, J. J.. Chinese Academy of Sciences; República de ChinaFil: Rattanasoon, S.. National Astronomical Research Institute of Thailand; TailandiaFil: Aukkaravittayapun, S.. National Astronomical Research Institute of Thailand; TailandiaFil: Liao, W. P.. Chinese Academy of Sciences; República de ChinaFil: Zhao, E. G.. Chinese Academy of Sciences; República de ChinaFil: Zhang, J.. Chinese Academy of Sciences; República de ChinaFil: Fernandez Lajus, Eduardo Eusebio. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica la Plata; Argentin

Photometric study of three ultrashort-period contact binaries

We carried out high-precision photometric observations of three eclipsing ultrashort-period contact binaries (USPCBs). Theoretical models were fitted to the light curves by means of the Wilson-Devinney code. The solutions suggest that the three targets have evolved to a contact phase. The photometric results are as follows: (a) 1SWASP J030749.87−365201.7, q= 0.439 ± 0.003 , f= 0.0 ± 3.6 % ; (b) 1SWASP J213252.93−441822.6, q= 0.560 ± 0.003 , f= 14.2 ± 1.9 % ; (c) 1SWASP J200059.78+054408.9, q= 0.436 ± 0.008 , f= 58.4 ± 1.8 %. The light curves show O’Connell effects, which can be modeled by the assumed cool spots. The cool spots models are strongly supported by the night-to-night variations in the I-band light curves of 1SWASP J030749.87−365201.7. For a comparative study, we collected the whole set of 28 well-studied USPCBs with P 50 %). Generally, contact binaries with deep fill-out factors are going to merge, but it is believed that USPCBs have just evolved to a contact phase. Hence, the deep USPCB 1SWASP J200059.78+054408.9 seems to be a contradiction, making it very interesting. Particularly, 1SWASP J030749.87−365201.7 is a zero contact binary in thermal equilibrium, implying that it should be a turn-off sample as predicted by the thermal relaxation oscillation (TRO) theory.Instituto de Astrofísica de La Plat

Photometric study of three ultrashort-period contact binaries

We carried out high-precision photometric observations of three eclipsing ultrashort-period contact binaries (USPCBs). Theoretical models were fitted to the light curves by means of the Wilson-Devinney code. The solutions suggest that the three targets have evolved to a contact phase. The photometric results are as follows: (a) 1SWASP J030749.87−365201.7, q= 0.439 ± 0.003 , f= 0.0 ± 3.6 % ; (b) 1SWASP J213252.93−441822.6, q= 0.560 ± 0.003 , f= 14.2 ± 1.9 % ; (c) 1SWASP J200059.78+054408.9, q= 0.436 ± 0.008 , f= 58.4 ± 1.8 %. The light curves show O’Connell effects, which can be modeled by the assumed cool spots. The cool spots models are strongly supported by the night-to-night variations in the I-band light curves of 1SWASP J030749.87−365201.7. For a comparative study, we collected the whole set of 28 well-studied USPCBs with P 50 %). Generally, contact binaries with deep fill-out factors are going to merge, but it is believed that USPCBs have just evolved to a contact phase. Hence, the deep USPCB 1SWASP J200059.78+054408.9 seems to be a contradiction, making it very interesting. Particularly, 1SWASP J030749.87−365201.7 is a zero contact binary in thermal equilibrium, implying that it should be a turn-off sample as predicted by the thermal relaxation oscillation (TRO) theory.Instituto de Astrofísica de La Plat

Aberrant repair and fibrosis development in skeletal muscle

The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem cells orchestrate their activities to restore tissue homeostasis. However, during chronic tissue damage, such as in muscular dystrophies, the inflammatory-cell infiltration and fibroblast activation persists, while the reparative capacity of stem cells (satellite cells) is attenuated. Abnormal dystrophic muscle repair and its end stage, fibrosis, represent the final common pathway of virtually all chronic neurodegenerative muscular diseases. As our understanding of the pathogenesis of muscle fibrosis has progressed, it has become evident that the muscle provides a useful model for the regulation of tissue repair by the local microenvironment, showing interplay among muscle-specific stem cells, inflammatory cells, fibroblasts and extracellular matrix components of the mammalian wound-healing response. This article reviews the emerging findings of the mechanisms that underlie normal versus aberrant muscle-tissue repair

Photometric study of three ultrashort-period contact binaries

We carried out high-precision photometric observations of three eclipsing ultrashort-period contact binaries (USPCBs). Theoretical models were fitted to the light curves by means of the Wilson-Devinney code. The solutions suggest that the three targets have evolved to a contact phase. The photometric results are as follows: (a) 1SWASP J030749.87−365201.7, q= 0.439 ± 0.003 , f= 0.0 ± 3.6 % ; (b) 1SWASP J213252.93−441822.6, q= 0.560 ± 0.003 , f= 14.2 ± 1.9 % ; (c) 1SWASP J200059.78+054408.9, q= 0.436 ± 0.008 , f= 58.4 ± 1.8 %. The light curves show O’Connell effects, which can be modeled by the assumed cool spots. The cool spots models are strongly supported by the night-to-night variations in the I-band light curves of 1SWASP J030749.87−365201.7. For a comparative study, we collected the whole set of 28 well-studied USPCBs with P 50 %). Generally, contact binaries with deep fill-out factors are going to merge, but it is believed that USPCBs have just evolved to a contact phase. Hence, the deep USPCB 1SWASP J200059.78+054408.9 seems to be a contradiction, making it very interesting. Particularly, 1SWASP J030749.87−365201.7 is a zero contact binary in thermal equilibrium, implying that it should be a turn-off sample as predicted by the thermal relaxation oscillation (TRO) theory.Fil: Liu, L.. Chinese Academy of Sciences; República de ChinaFil: Qian, S. B.. Chinese Academy of Sciences; República de ChinaFil: Fernandez Lajus, Eduardo Eusebio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Essam, A.. National Research Institute of Astronomy and Geophysics; EgiptoFil: El Sadek, M. A.. National Research Institute of Astronomy and Geophysics; EgiptoFil: Xiong, X.. Chinese Academy of Sciences; República de Chin

Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients

Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 mu s; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides.Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V.Conclusion The findings suggest that DBS can suppress pathological 11-30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective

Evolutionary states of the two shortest period O-type overcontact binaries V382 Cyg and TU Mus

Up to now, V382 Cyg and TU Mus are the only two discovered O-type overcontact binary stars with periods less than two days (P = 1.8855 and 1.3873 d). Both systems contain a visual companion. New eclipse times and analyses of orbital period variations of the two systems are presented. It is discovered that the periods of both binaries show cyclic oscillations with periods of 47.70 and 47.73 yr, while they undergo continuous increases at rates of dP/dt = +4.4 × 10−7 and +4.0 × 10−7 d yr−1, respectively. The periodic variations can be interpreted as light travel times effects caused by the presence of invisible tertiary components suggesting that they may be quadruple systems. It is possible that the additional bodies may play an important role in the formation and evolution of the two massive overcontact binaries by removing angular momentum from the central systems, and causing the eclipsing pairs to have lower angular momentum and shorter initial orbital periods. In this way, the original detached systems can evolve into the present overcontact configurations via a Case A mass transfer. This is in agreement with the observed long-term period increase of V382 Cyg and TU Mus, which can be explained by mass transfers from the less massive components to the more massive ones. It is found that the time-scales of the long-term period variations of both systems are much longer than the thermal time-scales of the secondary components, but are close to their nuclear time-scales. This suggests that the two massive binaries have been through the rapid mass-transfer evolutionary stage on the thermal time-scales of the secondaries, and they are now on the slow phase of Case A mass transfer. It is shown that massive overcontact binaries are going through a short-lived overcontact configuration during the evolutionary phases of Case A mass transfer, which is different from the situation of late-type overcontact binary stars where components remain in good overcontact configuration driving by a combination of thermal relaxation oscillation and variable angular momentum loss via change in overcontact depth. This conclusion is in agreement with the distribution of overcontact binary stars along with the orbital period.Facultad de Ciencias Astronómicas y GeofísicasInstituto de Astrofísica de La Plat

Evolutionary states of the two shortest period O-type overcontact binaries V382 Cyg and TU Mus

Up to now, V382 Cyg and TU Mus are the only two discovered O-type overcontact binary stars with periods less than two days (P = 1.8855 and 1.3873 d). Both systems contain a visual companion. New eclipse times and analyses of orbital period variations of the two systems are presented. It is discovered that the periods of both binaries show cyclic oscillations with periods of 47.70 and 47.73 yr, while they undergo continuous increases at rates of dP/dt = +4.4 × 10−7 and +4.0 × 10−7 d yr−1, respectively. The periodic variations can be interpreted as light travel times effects caused by the presence of invisible tertiary components suggesting that they may be quadruple systems. It is possible that the additional bodies may play an important role in the formation and evolution of the two massive overcontact binaries by removing angular momentum from the central systems, and causing the eclipsing pairs to have lower angular momentum and shorter initial orbital periods. In this way, the original detached systems can evolve into the present overcontact configurations via a Case A mass transfer. This is in agreement with the observed long-term period increase of V382 Cyg and TU Mus, which can be explained by mass transfers from the less massive components to the more massive ones. It is found that the time-scales of the long-term period variations of both systems are much longer than the thermal time-scales of the secondary components, but are close to their nuclear time-scales. This suggests that the two massive binaries have been through the rapid mass-transfer evolutionary stage on the thermal time-scales of the secondaries, and they are now on the slow phase of Case A mass transfer. It is shown that massive overcontact binaries are going through a short-lived overcontact configuration during the evolutionary phases of Case A mass transfer, which is different from the situation of late-type overcontact binary stars where components remain in good overcontact configuration driving by a combination of thermal relaxation oscillation and variable angular momentum loss via change in overcontact depth. This conclusion is in agreement with the distribution of overcontact binary stars along with the orbital period.Facultad de Ciencias Astronómicas y GeofísicasInstituto de Astrofísica de La Plat

Context-dependent roles of cellular senescence in normal, aged, and disease states.

Cellular senescence is a state of irreversible cell cycle arrest that often emerges after tissue damage and in age-related diseases. Through the production of a multicomponent secretory phenotype (SASP), senescent cells can impact the regeneration and function of tissues. However, the effects of senescent cells and their SASP are very heterogeneous and depend on the tissue environment and type as well as the duration of injury, the degree of persistence of senescent cells and the organism's age. While the transient presence of senescent cells is widely believed to be beneficial, recent data suggest that it is detrimental for tissue regeneration after acute damage. Furthermore, although senescent cell persistence is typically associated with the progression of age-related chronic degenerative diseases, it now appears to be also necessary for correct tissue function in the elderly. Here, we discuss what is currently known about the roles of senescent cells and their SASP in tissue regeneration in ageing and age-related diseases, highlighting their (negative and/or positive) contributions. We provide insight for future research, including the possibility of senolytic-based therapies and cellular reprogramming, with aims ranging from enhancing tissue repair to extending a healthy lifespan.Work in the authors’ laboratory is supported by MINECO-Spain (RTI2018-096068), H2020 European Research Council-2016-AdG-741966, LaCaixaHEALTH-HR17-00040, MWRF, French Muscular Dystrophy Association, Muscular Dystrophy Association, Fundacio LaMarató TV3 (80/19-202021 and 137/ 38-202033) and UPGRADE-H2020-825825; and María-de-Maeztu-Program for Units of Excellence to UPF (MDM-2014-0370), Severo Ochoa-Program for Centers of Excellence to CNIC (SEV-2015-0505).S