5,711 research outputs found
Scientific applications of radio and radar tracking in the space program Conference proceedings
Radar and radio tracking applications in space progra
ICE Second Halley radial: TDA mission support and DSN operations
The article documents the operations encompassing the International Cometary Explorer (ICE) second Halley radial experiment centered around March 28, 1986. The support was provided by the Deep Space Network (DSN) 64-meter subnetwork. Near continuous support was provided the last two weeks of March and the first two weeks of April to insure the collection of adequate background data for the Halley radial experiment. During the last week of March, plasma wave measurements indicate that ICE was within the Halley heavy ion pick-up region
Cross-correlations in scaling analyses of phase transitions
Thermal or finite-size scaling analyses of importance sampling Monte Carlo
time series in the vicinity of phase transition points often combine different
estimates for the same quantity, such as a critical exponent, with the intent
to reduce statistical fluctuations. We point out that the origin of such
estimates in the same time series results in often pronounced
cross-correlations which are usually ignored even in high-precision studies,
generically leading to significant underestimation of statistical fluctuations.
We suggest to use a simple extension of the conventional analysis taking
correlation effects into account, which leads to improved estimators with often
substantially reduced statistical fluctuations at almost no extra cost in terms
of computation time.Comment: 4 pages, RevTEX4, 3 tables, 1 figur
Optimal discrete stopping times for reliability growth tests
Often, the duration of a reliability growth development test is specified in advance and the decision to terminate or continue testing is conducted at discrete time intervals. These features are normally not captured by reliability growth models. This paper adapts a standard reliability growth model to determine the optimal time for which to plan to terminate testing. The underlying stochastic process is developed from an Order Statistic argument with Bayesian inference used to estimate the number of faults within the design and classical inference procedures used to assess the rate of fault detection. Inference procedures within this framework are explored where it is shown the Maximum Likelihood Estimators possess a small bias and converges to the Minimum Variance Unbiased Estimator after few tests for designs with moderate number of faults. It is shown that the Likelihood function can be bimodal when there is conflict between the observed rate of fault detection and the prior distribution describing the number of faults in the design. An illustrative example is provided
sscMap: An extensible Java application for connecting small-molecule drugs using gene-expression signatures
Background: Connectivity mapping is a process to recognize novel
pharmacological and toxicological properties in small molecules by comparing
their gene expression signatures with others in a database. A simple and robust
method for connectivity mapping with increased specificity and sensitivity was
recently developed, and its utility demonstrated using experimentally derived
gene signatures.
Results: This paper introduces sscMap (statistically significant connections'
map), a Java application designed to undertake connectivity mapping tasks using
the recently published method. The software is bundled with a default
collection of reference gene-expression profiles based on the publicly
available dataset from the Broad Institute Connectivity Map 02, which includes
data from over 7000 Affymetrix microarrays, for over 1000 small-molecule
compounds, and 6100 treatment instances in 5 human cell lines. In addition, the
application allows users to add their custom collections of reference profiles
and is applicable to a wide range of other 'omics technologies.
Conclusions: The utility of sscMap is two fold. First, it serves to make
statistically significant connections between a user-supplied gene signature
and the 6100 core reference profiles based on the Broad Institute expanded
dataset. Second, it allows users to apply the same improved method to
custom-built reference profiles which can be added to the database for future
referencing. The software can be freely downloaded from
http://purl.oclc.org/NET/sscMapComment: 3 pages, 1 table, 1 eps figur
Cost-effectiveness of asthma control: an economic appraisal of the GOAL study
<i>Background</i>: The Gaining Optimal Asthma ControL (GOAL) study has shown the superiority of a combination of salmeterol/fluticasone propionate (SFC) compared with fluticasone propionate alone (FP) in terms of improving guideline defined asthma control.
<i>Methods</i>: Clinical and economic data were taken from the GOAL study, supplemented with data on health related quality of life, in order to estimate the cost per quality adjusted life year (QALY) results for each of three strata (previously corticosteroid-free, low- and moderate-dose corticosteroid users). A series of statistical models of trial outcomes was used to construct cost effectiveness estimates across the strata of the multinational GOAL study including adjustment to the UK experience. Uncertainty was handled using the non-parametric bootstrap. Cost-effectiveness was compared with other treatments for chronic conditions.
<i>Result</i>: Salmeterol/fluticasone propionate improved the proportion of patients achieving totally and well-controlled weeks resulting in a similar QALY gain across the three strata of GOAL. Additional costs of treatment were greatest in stratum 1 and least in stratum 3, with some of the costs offset by reduced health care resource use. Cost-effectiveness by stratum was £7600 (95% CI: £4800–10 700) per QALY gained for stratum 3; £11 000 (£8600–14 600) per QALY gained for stratum 2; and £13 700 (£11 000–18 300) per QALY gained for stratum 1.
<i>Conclusion</i>: The GOAL study previously demonstrated the improvement in total control associated with the use of SFC compared with FP alone. This study suggests that this improvement in control is associated with cost-per-QALY figures that compare favourably with other uses of scarce health care resources
Linear regression for numeric symbolic variables: an ordinary least squares approach based on Wasserstein Distance
In this paper we present a linear regression model for modal symbolic data.
The observed variables are histogram variables according to the definition
given in the framework of Symbolic Data Analysis and the parameters of the
model are estimated using the classic Least Squares method. An appropriate
metric is introduced in order to measure the error between the observed and the
predicted distributions. In particular, the Wasserstein distance is proposed.
Some properties of such metric are exploited to predict the response variable
as direct linear combination of other independent histogram variables. Measures
of goodness of fit are discussed. An application on real data corroborates the
proposed method
Analyzing 2D gel images using a two-component empirical bayes model
<p>Abstract</p> <p>Background</p> <p>Two-dimensional polyacrylomide gel electrophoresis (2D gel, 2D PAGE, 2-DE) is a powerful tool for analyzing the proteome of a organism. Differential analysis of 2D gel images aims at finding proteins that change under different conditions, which leads to large-scale hypothesis testing as in microarray data analysis. Two-component empirical Bayes (EB) models have been widely discussed for large-scale hypothesis testing and applied in the context of genomic data. They have not been implemented for the differential analysis of 2D gel data. In the literature, the mixture and null densities of the test statistics are estimated separately. The estimation of the mixture density does not take into account assumptions about the null density. Thus, there is no guarantee that the estimated null component will be no greater than the mixture density as it should be.</p> <p>Results</p> <p>We present an implementation of a two-component EB model for the analysis of 2D gel images. In contrast to the published estimation method, we propose to estimate the mixture and null densities simultaneously using a constrained estimation approach, which relies on an iteratively re-weighted least-squares algorithm. The assumption about the null density is naturally taken into account in the estimation of the mixture density. This strategy is illustrated using a set of 2D gel images from a factorial experiment. The proposed approach is validated using a set of simulated gels.</p> <p>Conclusions</p> <p>The two-component EB model is a very useful for large-scale hypothesis testing. In proteomic analysis, the theoretical null density is often not appropriate. We demonstrate how to implement a two-component EB model for analyzing a set of 2D gel images. We show that it is necessary to estimate the mixture density and empirical null component simultaneously. The proposed constrained estimation method always yields valid estimates and more stable results. The proposed estimation approach proposed can be applied to other contexts where large-scale hypothesis testing occurs.</p
Randomized Benchmarking of Quantum Gates
A key requirement for scalable quantum computing is that elementary quantum
gates can be implemented with sufficiently low error. One method for
determining the error behavior of a gate implementation is to perform process
tomography. However, standard process tomography is limited by errors in state
preparation, measurement and one-qubit gates. It suffers from inefficient
scaling with number of qubits and does not detect adverse error-compounding
when gates are composed in long sequences. An additional problem is due to the
fact that desirable error probabilities for scalable quantum computing are of
the order of 0.0001 or lower. Experimentally proving such low errors is
challenging. We describe a randomized benchmarking method that yields estimates
of the computationally relevant errors without relying on accurate state
preparation and measurement. Since it involves long sequences of randomly
chosen gates, it also verifies that error behavior is stable when used in long
computations. We implemented randomized benchmarking on trapped atomic ion
qubits, establishing a one-qubit error probability per randomized pi/2 pulse of
0.00482(17) in a particular experiment. We expect this error probability to be
readily improved with straightforward technical modifications.Comment: 13 page
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