A decomposition-based uncertainty quantification approach for environmental impacts of aviation technology and operation

As a measure to manage the climate impact of aviation, significant enhancements to aviation technologies and operations are necessary. When assessing these enhancements and their respective impacts on the climate, it is important that we also quantify the associated uncertainties. This is important to support an effective decision and policymaking process. However, such quantification of uncertainty is challenging, especially in a complex system that comprises multiple interacting components. The uncertainty quantification task can quickly become computationally intractable and cumbersome for one individual or group to manage. Recognizing the challenge of quantifying uncertainty in multicomponent systems, we utilize a divide-and-conquer approach, inspired by the decomposition-based approaches used in multidisciplinary analysis and optimization. Specifically, we perform uncertainty analysis and global sensitivity analysis of our multicomponent aviation system in a decomposition-based manner. In this work, we demonstrate how to handle a high-dimensional multicomponent interface using sensitivity-based dimension reduction and a novel importance sampling method. Our results demonstrate that the decomposition-based uncertainty quantification approach can effectively quantify the uncertainty of a feed-forward multicomponent system for which the component models are housed in different locations and owned by different groups. Keywords: Aviation Environmental Impact; Decomposition; Global Sensitivity Analysis; Uncertainty Quantificatio

Trichinella britovi etiological agent of sylvatic trichinellosis in the Republic of Guinea (West Africa) and a re-evaluation of geographical distribution for encapsulated species in Africa

In West Africa, Trichinella infection was documented in humans and animals from Senegal in the 1960s, and the biological characters of one isolate showed a lower infectivity to domestic pigs and rodents when compared with that of a Trichinella spiralis pig isolate from Europe. To identify the Trichinella species present in West Africa, a survey was conducted in a total of 160 wild animals in the Republic of Guinea. Three Viverridae, one true civet (Viverra civetta) and two African palm civets (Nandinia binotata) from the Fouta Djallon Massif, Pilimini Subprefecture, were found positive by artificial digestion of muscle samples. Trichinella larvae from these three viverrids were identified as Trichinella britovi and no difference was detected in three examined sequences from these African isolates and the reference strain of T. britovi from Europe, indicating common ancestry, an historically continuous geographic distribution, and recent isolation for African and European populations. The detection of T. britovi in West Africa modifies our knowledge about the distribution of encapsulated species of Trichinella in Africa. Thus, Trichinella nelsoni is now considered to have a distribution limited to the Eastern part of the Afrotropical region from Kenya to South Africa. This provides a plausible explanation for the presence of Trichinella T8 in Namibia and South Africa, and further suggests that T. britovi could be the Trichinella species circulating among wild animals of Northern Africa

Estrategias pedagógicas para el desarrollo de una ayuda educativa tecnológica que facilite el proceso orientación aprendizaje de la asignatura seguridad industrial, en los estudiantes del programa de técnico profesional en salud ocupacional de la corporación instituto de artes y ciencias

Especialización en Estudios PedagógicosThe present research work is composed of four chapters that contain everything related to the theoretical, historical, legal and institutional foundations that are part of a comprehensive training of the Professional Technician in Occupational Health of the Institute of Arts and Sciences, as well as the information collected through different techniques of qualitative research and a proposal to implement pedagogical strategies for the development of technological educational aid to facilitate the orientation-learning process of the subject Industrial Safety in the students of the Occupational Health Professional Technician Program of the Institute of Arts and Sciences. Based on the real need to provide the student and the facilitator with optimal didactic resources for their performance and development of the subject.El presente trabajo investigativo está integrado por cuatro capítulos que contienen todo lo relacionado con los fundamentos teóricos, históricos, legales e institucionales que hacen parte de una formación integral del estudiante de técnico Profesional en Salud Ocupacional de la Corporación Instituto de Artes y Ciencias, así como la información recolectada a través de diferentes técnicas de la investigación cualitativa y una propuesta para implementar estrategias pedagógicas para el desarrollo de una ayuda educativa tecnológica para facilitar el proceso orientación-aprendizaje de la asignatura Seguridad Industrial en los estudiantes del Programa de técnico profesional en Salud Ocupacional de la Corporación Instituto de Artes y Ciencias. Basada en la necesidad real de proporcionar al estudiante y al facilitador recursos didácticos óptimos para su desempeño y desarrollo de la asignatura

Phytochemical Characterization and Antiplatelet Activity of Mexican Red Wines and Their By-products

Red wines and their grape pomaces are important sources of phenolic compounds. Inhibition of plateletaggregation is one of the mechanisms proposed for cardioprotective effect of phenolic compounds fromwine and grape pomace; however, phenolic content is affected by region, variety and winemaking process.In the present study, antiplatelet effect of red wines and grape pomaces was related to its phenolic content(determined by spectrophotometric techniques) and profile (determined using HPLC-MS/MS). in vitroAnti-platelet aggregation was determined using human platelets. Results showed that Zinfandel wine andCabernet Sauvignon grape pomace presented the highest phenolic content. Phenolic profiles presenteddifferences in the presence of flavonoids and oligomeric tannins. Results from platelet aggregationshowed that Merlot and Petit Verdot wines and Petit Verdot grape pomace sample presented the highestantiaggregant effect. These results indicate that antiplatelet effect could be related to phenolic profile thanphenolic content in wines and grape pomaces. Cardioprotective effect of red wines and grape pomacecould be related to specific compounds such as monomeric and polymeric flavan-3-ols

Pepper mild mottle virus in different water matrices

Abstract Background Pepper mild mottle virus (PMMoV), a plant virus belonging to Virgoviridae, has recently been suggested as a potential viral indicator for faecal pollution in aquatic environments, since it has been found to be abundantly excreted from healthy human subjects. Methods The occurrence, amount and diversity of PMMoV was investigated in water environments by nested RT-PCR and TaqMan based quantitative PCR. During 2017-2019, 251 water samples (92 urban wastewaters, 32 treated effluents, 16 surface water samples, 9 estuarine samples, 20 seawater samples, 67 groundwater samples, and 15 drinking waters) were analysed. Results PMMoV was detected in 73/92 (79%) wastewater samples, 22/32 (69%) treated sewages, 11/16 (69%) river samples, 6/9 (67%) estuarine samples, 5/20 (25%) bathing waters, and 9/67 (13%) groundwaters, whilst drinking water samples tested always negative. Mean viral concentrations (genome copies/L) were: raw sewage 4.2 × 106, treated sewage 7.4 × 105, river 3.2 × 103, estuarine waters 9.6 × 102, seawaters 3.0 × 102, groundwaters 7.7 × 101. Conclusions This study highlights the significant occurrence of PMMoV in aquatic environment in Italy, and a clear gradient of viral prevalence and concentrations from polluted to clean waters (wastewaters to drinking waters). Key messages PMMoV is ubiquitous throughout the water cycle in Italy with different concentrations. Studies are needed to evaluate the suitability of PMMoV as a viral indicator for human fecal pollution in waters

Prediction equations of skinfold in children of primary school

El objetivo de este trabajo es crear ecuaciones que estimen las medidas de los pliegues cutáneos para escolares de 6 a 13 años de edad. Como resultado se obtuvieron catorce ecuaciones que estiman algunos pliegues cutáneos. Las ecuaciones se validaron con muestras aleatorias de 479 niñas y 541 niños del estado de Puebla y otras 2 muestras aleatorias del estado de Veracruz con 155 niñas y 146 niños respectivamente; las mediciones directas se realizaron con la metodología y unidades ISAK (International Society for the Advancement of Kinanthropometry)The aim of this paper is to create equations that predict the skinfold measures for school children 6 to 13 years old. Fourteen resulting equations were derived to estimate some measures of skinfold. The equations were validated with random samples of 479 girls and 541 boys in the state of Puebla and 2 other random samples of the state of Veracruz with 155 girls and 146 boys respectively; direct measurements were performed with the methodology and units ISAK (International Society for the Advancement of Kinanthropometr

Enhanced Joule Heating in Umbral Dots

We present a study of magnetic profiles of umbral dots (UDs) and its consequences on the Joule heating mechanisms. Hamedivafa (2003) studied Joule heating using vertical component of magnetic field. In this paper UDs magnetic profile has been investigated including the new azimuthal component of magnetic field which might explain the relatively larger enhancement of Joule heating causing more brightness near circumference of UD.Comment: 8 pages, 1 figure, accepted in Solar Physic

Merging of Low-Mass Systems and the Origin of the Fundamental Plane

We present a new set of dissipationless N-body simulations to examine the feasibility of creating bright ellipticals (following the Kormendy relation) by hierarchically merging present-day early-type dwarf galaxies, and to study how the encounter parameters affect the location of the end-product in the $- R_{e}$ plane. We investigate the merging of one-component galaxies of both equal and different masses, the merging of two-component galaxy models to explore the effect of dark halos on the final galaxy characteristics, and the merging of ultracompact dwarf galaxies. We find that the increase of $$ with $R_e$ is attributable to an increase in the initial orbital energy. The merger remnants shift down in the $- R_{e}$ plane and fail to reach the KR. Thus, the KR is not reproducable by mergers of dwarf early-type systems, rendering untenable the theory that present-day dwarfs are responsible for even a small fraction of the present-day ellipticals, unless a considerable amount of dissipation is invoked. However, we do find that present-day dwarfs can be formed by the merger of ultra-compact dwarfs.Comment: 10 pages, 8 figures. Accepted for publication in MNRA

Serafino Zappacosta: An Enlightened Mentor and Educator

With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science. The authors discuss how the combination of Serafino Zappacosta's extraordinary commitment to teaching and passion for science created a fostering educational environment that led to the creation of the “Ruggero Ceppellini Advanced School of Immunology.” The review also illustrates how the research on the MHC and the inspirational scientific context in the Zappacosta's laboratory influenced the authors' early scientific interests, and subsequent professional work as immunologists

Statistical analysis plan for the Dual mTorc Inhibition in advanCed/recurrent Epithelial ovarian, fallopian tube or primary peritoneal cancer (of clear cell, endometrioid and high-grade serous type, and carcinosarcoma) trial (DICE)

Background Treatment for ovarian cancer includes platinum-based chemotherapy, but many women become resistant to chemotherapy, becoming platinum-resistant. Standard of care for these women is weekly paclitaxel chemotherapy, but cancers can often become paclitaxel resistant. TAK228, an investigational dual TORC1/2 inhibitor, is an oral therapy that can be added to standard treatment. The DICE trial is a phase II international multicentre, parallel-group, superiority clinical trial with 1:1, open label randomisation which has the aim of investigating the effectiveness of TAK228 plus weekly paclitaxel. The planned sample size is 124 women (62 per treatment arm) with platinum-resistant ovarian cancer. Objective To outline the planned analyses for DICE in a statistical analysis plan (SAP) before database hard lock and the start of analysis. This ensures that bias is minimised during the analysis phase. Results This SAP provides detailed descriptions of the analysis principles and statistical procedures for analysing primary and secondary outcomes of the trial. The primary outcome is overall progression-free survival (PFS). Secondary outcomes include progression-free survival (PFS) at 24 weeks, overall response rate (ORR), duration of response (DoR), time to progression (TTP), clinical benefit rate (CBR) at 4 months, Cancer Antigen 125 (CA125) response according to Gynaecological Cancer Intergroup (GCIG) criteria, overall survival (OS), safety and tolerability as assessed by adverse events and the quality-of-life questionnaires (EORTC QLQ-C30 and EORTC QLQ-OV28). This detailed description includes significance levels, sensitivity analyses and compliance analysis. Discussion The DICE trial will determine whether the addition of TAK228 to weekly paclitaxel chemotherapy shows a statistically significant improvement to participant’s progression free and overall survival and that the adverse events (AEs) and quality of life (QoL) are not significantly worse than the standard treatment. The study commenced recruitment in September 2018. An interim analysis was performed in early 2021, the results of which advised continuation of the trial. The study recruitment is ongoing and is due to complete by the end of 2021. Trial registration ClinicalTrials.govNCT03648489. Registered on 27 August 201