Étude expérimentale des transferts d'eau provoqués par l'irrigation sur une parcelle en moyenne vallée du fleuve Sénégal

Alors que l'irrigation paraît être le recours essentiel face aux besoins croissants de la population mondiale en céréales, la dégradation des sols et des eaux annihile presque totalement les efforts d'aménagement. Aussi l'étude de la dégradation des sols dans la moyenne vallée du fleuve Sénégal constitue l'un des quatre objectifs du pôle de recherches sur les systèmes irrigués sahéliens qui regroupe quatre pays dont le Mali, la Mauritanie, le Niger et le Sénégal. Le suivi de l'évolution des eaux et des sols sous culture apparaît indispensable pour garantir une agriculture irriguée rentable et durable dans la zone. Dans cette région, les risques de dégradation des sols font suite à l'effet de deux processus de dégradation que sont l'alcalinisation et la salinisation des sols. Ces types de dégradation sont fortement corrélés à la remontée des nappes d'eaux souterraines. Dans cet article, l'étude des transferts d'eau dans les parcelles irriguées par le biais d'un suivi expérimental " in situ " met en évidence les relations existantes entre les eaux d'irrigation et les mouvements de la nappe. L'étude a permis une meilleure compréhension de la dynamique hydrique au sein de la parcelle : saturation du profil et processus de recharge de la nappe. Elle a également permis de montrer que les échanges avec la nappe pendant la période d'irrigation sont négligeables. Cette pratique de la riziculture inondée, entraîne une variation de stock importante qui représente plus de 40% des apports et qui se traduit par une remontée de nappe de près de 2 mètres.Whereas irrigation appears to be the main approach to satisfy the growing worldwide demand for cereal, soil and water degradation continues to be an on-going problem in agriculture development. One of the main four concerns of the regional group for research on Sahelian irrigated systems (including Mali, Mauritania, Niger and Senegal) is soil degradation in the middle Senegal River valley. These soils are subject to various forms of degradation, mainly from salinisation and/or alkalinisation. These degradation processes are strongly correlated with water table dynamics, with water level fluctuations being significant. Therefore, to guarantee sustainable development of irrigated agriculture in the area, irrigation must be coupled with complete and permanent monitoring of soil and water quality.In this paper, we present a complete study concerning water transfer in irrigated plots and its effects on the groundwater table. The experimental site is located in the Podor region, at 16°.37'N, 14°.52'W in the Donaye irrigated area. The surface area is about 50 ha. Water supply is assured by filling a main channel using a group of pumps on the Doué River. Irrigation of the parcels is performed with siphons from this channel. The experimental plot of 0.33 ha is used for an underwater rice crop. One or two rice crop production harvests are made every year, with the decision been taken by the farmers. There is no drainage system in the area.The experimental plot was equipped with 8 piezometers located along a stream line. One is situated between the plot and the river in order to study the water movements caused by the exchange between the groundwater and the water in the river. Three are situated in the plot, one close to the Doué River, one in the middle of the plot and one near a dam, which is the opposite boundary compared to the river. Four other piezometers are located beyond the dam to estimate groundwater input and output at this boundary. Five tensiometers at 20, 40, 60, 95 and 135 cm depth are placed close to the piezometers located in the plot. Four water content profiles were measured during the irrigation period at depths 20, 40, 60 95 and 135 cm and the irrigation was performed over 84 days.The water table level variations at 2 meters were recorded. The groundwater inflow decreased during the first part of the irrigation period due to infiltration below the irrigated experimental plot. This inflow increased during a second period due to water level variations in the river close to this site. At the output, the head gradient did not vary appreciably and the outflow was assumed to be constant during the observation period. Moreover, this gradient is quite low and the flow rate is very low. The water content and pressure profiles clearly show the infiltration of water in the soil during irrigation. The head gradients show the water movement in the unsaturated soil during infiltration and evaporation. Upward flow due to evaporation is observed at about 10 days after irrigation. The last measured water profile (76 days after the end of irrigation) shows that evaporation modifies the water content profile until at least a depth of 120 cm.The water balance during the irrigation period showed that the input due to irrigation and precipitation was equal to 4150 m3. The evapotranspiration output was estimated to be 2370 m3. Groundwater exchange at the downstream boundary can be neglected during the duration of irrigation (84 days), since the average hydraulic gradient remained low (less than 0.8 %) and the hydraulic conductivity of the aquifer was not important (about 250 cm/day). It was assumed that the water storage quantified with the rise of the groundwater level was equal to the difference between surface input and evapotranspiration (more than 40 % of the contributions), leading to a 27 % change in water content, which is quite reasonable for this type of soil (clay).The stored water was then recovered by evapotranspiration and groundwater outflow at the plot boundaries. We are away from a reasonable irrigation that would reduce the used water quantity and decrease the risk of soil degradation. This study allows a better understanding of the water dynamics in the experimental plot, which includes soil saturation, recharge processes, and exchanges between the aquifer and the river

Efficient Learning of Accurate Surrogates for Simulations of Complex Systems

Machine learning methods are increasingly used to build computationally inexpensive surrogates for complex physical models. The predictive capability of these surrogates suffers when data are noisy, sparse, or time-dependent. As we are interested in finding a surrogate that provides valid predictions of any potential future model evaluations, we introduce an online learning method empowered by optimizer-driven sampling. The method has two advantages over current approaches. First, it ensures that all turning points on the model response surface are included in the training data. Second, after any new model evaluations, surrogates are tested and "retrained" (updated) if the "score" drops below a validity threshold. Tests on benchmark functions reveal that optimizer-directed sampling generally outperforms traditional sampling methods in terms of accuracy around local extrema, even when the scoring metric favors overall accuracy. We apply our method to simulations of nuclear matter to demonstrate that highly accurate surrogates for the nuclear equation of state can be reliably auto-generated from expensive calculations using a few model evaluations.Comment: 13 pages, 6 figures, submitted to Nature Machine Intelligenc

In-situ fluorescence spectroscopy indicates total bacterial abundance and dissolved organic carbon

We explore in-situ fluorescence spectroscopy as an instantaneous indicator of total bacterial abundance and faecal contamination in drinking water. Eighty-four samples were collected outside of the recharge season from groundwater-derived water sources in Dakar, Senegal. Samples were analysed for tryptophan-like (TLF) and humic-like (HLF) fluorescence in-situ, total bacterial cells by flow cytometry, and potential indicators of faecal contamination such as thermotolerant coliforms (TTCs), nitrate, and in a subset of 22 samples, dissolved organic carbon (DOC). Significant single-predictor linear regression models demonstrated that total bacterial cells were the most effective predictor of TLF, followed by on-site sanitation density; TTCs were not a significant predictor. An optimum multiple-predictor model of TLF incorporated total bacterial cells, nitrate, nitrite, on-site sanitation density, and sulphate (r2 0.68). HLF was similarly related to the same parameters as TLF, with total bacterial cells being the best correlated (ρs 0.64). In the subset of 22 sources, DOC clustered with TLF, HLF, and total bacterial cells, and a linear regression model demonstrated HLF was the best predictor of DOC (r2 0.84). The intergranular nature of the aquifer, timing of the study, and/or non-uniqueness of the signal to TTCs can explain the significant associations between TLF/HLF and indicators of faecal contamination such as on-site sanitation density and nutrients but not TTCs. The bacterial population that relates to TLF/HLF is likely to be a subsurface community that develops in-situ based on the availability of organic matter originating from faecal sources. In-situ fluorescence spectroscopy instantly indicates a drinking water source is impacted by faecal contamination but it remains unclear how that relates specifically to microbial risk in this setting

Epidemiological Interactions between Urogenital and Intestinal Human Schistosomiasis in the Context of Praziquantel Treatment across Three West African Countries

© 2015 Knowles et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article

Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report

<p>Abstract</p> <p>Introduction</p> <p>This is the first report of possible direct stimulation of hormone-resistant prostate cancer or interference of docetaxel cytotoxicity of prostate cancer in a patient with biochemical relapse of prostatic-specific antigen. This observation is of clinical and metabolic importance, especially at a time when more than 80 countries have fortified food supplies with folic acid and some contemplate further fortification with vitamin B₁₂.</p> <p>Case presentation</p> <p>Our patient is a 71-year-old Caucasian man who had been diagnosed in 1997 with prostate cancer, stage T1c, and Gleason score 3+4 = 7. His primary treatment included intermittent androgen deprivation therapy including leuprolide + bicalutamide + deutasteride, ketoconazole + hydrocortisone, nilandrone and flutamide to resistance defined as biochemical relapse of PSA. While undergoing docetaxel therapy to treat a continually increasing prostate-specific antigen level, withdrawal of 10 daily doses of a supplement containing 500 μg of vitamin B₁₂as cyanocobalamin, as well as 400 μg of folic acid as pteroylglutamic acid and 400 μg of L-5-methyltetrahydrofolate for a combined total of 800 μg of mixed folates, was associated with a return to a normal serum prostatic-specific antigen level.</p> <p>Conclusion</p> <p>This case report illustrates the importance of the effects of supplements containing large amounts of folic acid, L-5-methyltetrahydrofolate, and cyanocobalamin on the metabolism of prostate cancer cells directly and/or B vitamin interference with docetaxel efficacy. Physicians caring for patients with prostate cancer undergoing watchful waiting, hormone therapy, and/or chemotherapy should consider the possible acceleration of tumor growth and/or metastasis and the development of drug resistance associated with supplement ingestion. We describe several pathways of metabolic and epigenetic interactions that could affect the observed changes in serum levels of prostate-specific antigen.</p

A Multicentre Randomized Controlled Trial of the Efficacy and Safety of Single-Dose Praziquantel at 40 mg/kg vs. 60 mg/kg for Treating Intestinal Schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil

Control of urinary and intestinal schistosomiasis is based on mass administration of praziquantel at the World Health Organization (WHO) recommended dose of 40 mg/kg, though some countries use 60 mg/kg. This multi-country randomized clinical trial compared the efficacy (cure and egg reduction rates three weeks post-treatment) and safety of these two doses for treating intestinal schistosomiasis in 856 patients in Brazil, Mauritania and Tanzania (Schistosoma mansoni), and The Philippines (S. japonicum). Transmission and infection intensities varied across the sites, but there was no bias or heterogeneity in efficacy outcomes. The two doses are equally effective in curing intestinal schistosomiasis; the higher dose may be less well tolerated, though effects are generally mild and transient. In endemic areas people can be re-infected; one year post-treatment patients on 60 mg/kg had fewer re-infections but this finding is difficult to explain. This study was conducted to respond to the demand for evidence about the dose of praziquantel when deployed in endemic countries. The results, along with those of systematic reviews, support the current WHO recommendation for using praziquantel at 40 mg/kg and should inform policy decisions in countries. The Philippines has already changed from 60 to 40 mg/kg after this study