Adverse drug events in patients with dementia and neuropsychiatric/behavioral, and psychological symptoms, a one-year prospective study

Older people usually present with adverse drug events (ADEs) with nonspecific symptoms such as cognitive decline, recurrent falls, reduced mobility, and/or major deterioration. The aims of this study were to assess the ADEs of patients with dementia and presenting neuropsychiatric/behavioral, and psychological symptoms in dementia (BPSD) and to categorize and identify the principal factors that allow to prevent ADEs, and separately ADEs that result in falls. To that end, a one-year prospective study in a psychogeriatric ward (July 2015 to July 2016) was performed. All patients admitted to this ward were eligible for enrolment. Patients who met any of the following criteria were excluded from the study: Patients without cognitive impairment, a length of stay under 7 days, and palliative or previous psychiatric pathology. We included 65 patients (60% women, 84.9 years ± 6.7) with mild to moderate cognitive impairment, moderate to severe functional dependence, and a high prevalence of geriatric syndromes and comorbidity. A total of 87.7% were taking five or more drugs (mean 9.0 ± 3.1). ADEs were identified during the interdisciplinary meeting and the follow up by clinical record. Sixty-eight ADEs (81.5% patients) were identified, of which 73.5% were not related to falls. From these, 80% were related to drugs of the nervous system. The Naranjo algorithm determined that 90% of ADEs were probable. The severity of the ADEs was Category E in 34 patients (68%). The number of preventable ADE according to the Schumork⁻Thornton test was 58%. The main ADE was drowsiness/somnolence (27.7%). ADEs related to falls represented a 26.5%. The balance between effective treatment and safety is complex in these patients. A medication review in interdisciplinary teams is an essential component to optimize safety prevention

Detection of the significant impact of source clustering on higher-order statistics with DES Year 3 weak gravitational lensing data

We demonstrate and measure the impact of source galaxy clustering on higher-order summary statistics of weak gravitational lensing data. By comparing simulated data with galaxies that either trace or do not trace the underlying density field, we show this effect can exceed measurement uncertainties for common higher-order statistics for certain analysis choices. Source clustering effects are larger at small scales and for statistics applied to combinations of low and high redshift samples, and diminish at high redshift. We evaluate the impact on different weak lensing observables, finding that third moments and wavelet phase harmonics are more affected than peak count statistics. Using Dark Energy Survey Year 3 data we construct null tests for the source-clustering-free case, finding a $p$-value of $p=4\times10^{-3}$ (2.6 $\sigma$) using third-order map moments and $p=3\times10^{-11}$ (6.5 $\sigma$) using wavelet phase harmonics. The impact of source clustering on cosmological inference can be either be included in the model or minimized through \textit{ad-hoc} procedures (e.g. scale cuts). We verify that the procedures adopted in existing DES Y3 cosmological analyses (using map moments and peaks) were sufficient to render this effect negligible. Failing to account for source clustering can significantly impact cosmological inference from higher-order gravitational lensing statistics, e.g. higher-order N-point functions, wavelet-moment observables (including phase harmonics and scattering transforms), and deep learning or field level summary statistics of weak lensing maps. We provide recipes both to minimise the impact of source clustering and to incorporate source clustering effects into forward-modelled mock data.Comment: 5 pages, 2 figures, submitted to MNRAS Letter

Beyond the 3rd moment: A practical study of using lensing convergence CDFs for cosmology with DES Y3

Widefield surveys of the sky probe many clustered scalar fields -- such as galaxy counts, lensing potential, gas pressure, etc. -- that are sensitive to different cosmological and astrophysical processes. Our ability to constrain such processes from these fields depends crucially on the statistics chosen to summarize the field. In this work, we explore the cumulative distribution function (CDF) at multiple scales as a summary of the galaxy lensing convergence field. Using a suite of N-body lightcone simulations, we show the CDFs' constraining power is modestly better than that of the 2nd and 3rd moments of the field, as they approximately capture the information from all moments of the field in a concise data vector. We then study the practical aspects of applying the CDFs to observational data, using the first three years of the Dark Energy Survey (DES Y3) data as an example, and compute the impact of different systematics on the CDFs. The contributions from the point spread function are 2-3 orders of magnitude below the cosmological signal, while those from reduced shear approximation contribute $\lesssim 1\%$ to the signal. Source clustering effects and baryon imprints contribute $1-10\%$. Enforcing scale cuts to limit systematics-driven biases in parameter constraints degrades these constraints a noticeable amount, and this degradation is similar for the CDFs and the moments. We also detect correlations between the observed convergence field and the shape noise field at $13\sigma$. We find that the non-Gaussian correlations in the noise field must be modeled accurately to use the CDFs, or other statistics sensitive to all moments, as a rigorous cosmology tool.Comment: 21 pages, 12 figure

Cosmology from Cross-Correlation of ACT-DR4 CMB Lensing and DES-Y3 Cosmic Shear

Cross-correlation between weak lensing of the Cosmic Microwave Background (CMB) and weak lensing of galaxies offers a way to place robust constraints on cosmological and astrophysical parameters with reduced sensitivity to certain systematic effects affecting individual surveys. We measure the angular cross-power spectrum between the Atacama Cosmology Telescope (ACT) DR4 CMB lensing and the galaxy weak lensing measured by the Dark Energy Survey (DES) Y3 data. Our baseline analysis uses the CMB convergence map derived from ACT-DR4 and $\textit{Planck}$ data, where most of the contamination due to the thermal Sunyaev Zel'dovich effect is removed, thus avoiding important systematics in the cross-correlation. In our modelling, we consider the nuisance parameters of the photometric uncertainty, multiplicative shear bias and intrinsic alignment of galaxies. The resulting cross-power spectrum has a signal-to-noise ratio $= 7.1$ and passes a set of null tests. We use it to infer the amplitude of the fluctuations in the matter distribution ($S_8 \equiv \sigma_8 (\Omega_{\rm m}/0.3)^{0.5} = 0.782\pm 0.059$) with informative but well-motivated priors on the nuisance parameters. We also investigate the validity of these priors by significantly relaxing them and checking the consistency of the resulting posteriors, finding them consistent, albeit only with relatively weak constraints. This cross-correlation measurement will improve significantly with the new ACT-DR6 lensing map and form a key component of the joint 6x2pt analysis between DES and ACT.Comment: 26 pages, 30 figures (including appendices). Data associated with this article is available at https://github.com/itrharrison/actdr4kappa-x-desy3gamma-dat

Dark Energy Survey Year 3 results: Curved-sky weak lensing mass map reconstruction

We present reconstructed convergence maps, mass maps, from the Dark Energy Survey (DES) third year (Y3) weak gravitational lensing data set. The mass maps are weighted projections of the density field (primarily dark matter) in the foreground of the observed galaxies. We use four reconstruction methods, each is a maximum a posteriori estimate with a different model for the prior probability of the map: Kaiser-Squires, null B-mode prior, Gaussian prior, and a sparsity prior. All methods are implemented on the celestial sphere to accommodate the large sky coverage of the DES Y3 data. We compare the methods using realistic \u39bCDM simulations with mock data that are closely matched to the DES Y3 data. We quantify the performance of the methods at the map level and then apply the reconstruction methods to the DES Y3 data, performing tests for systematic error effects. The maps are compared with optical foreground cosmic-web structures and are used to evaluate the lensing signal from cosmic-void profiles. The recovered dark matter map covers the largest sky fraction of any galaxy weak lensing map to date

The Dark Energy Survey Year 3 and eBOSS: constraining galaxy intrinsic alignments across luminosity and colour space

We present direct constraints on galaxy intrinsic alignments using the Dark Energy Survey Year 3 (DES Y3), the Extended Baryon Oscillation Spectroscopic Survey (eBOSS) and its precursor, the Baryon Oscillation Spectroscopic Survey (BOSS). Our measurements incorporate photometric red sequence (redMaGiC) galaxies from DES with median redshift $z\sim0.2-1.0$, luminous red galaxies (LRGs) from eBOSS at $z\sim0.8$, and also a SDSS-III BOSS CMASS sample at $z\sim0.5$. We measure two point intrinsic alignment correlations, which we fit using a model that includes lensing, magnification and photometric redshift error. Fitting on scales $6<r_{\rm p} < 70$ Mpc$/h$, we make a detection of intrinsic alignments in each sample, at $5\sigma-22\sigma$ (assuming a simple one parameter model for IAs). Using these red samples, we measure the IA-luminosity relation. Our results are statistically consistent with previous results, but offer a significant improvement in constraining power, particularly at low luminosity. With this improved precision, we see detectable dependence on colour between broadly defined red samples. It is likely that a more sophisticated approach than a binary red/blue split, which jointly considers colour and luminosity dependence in the IA signal, will be needed in future. We also compare the various signal components at the best fitting point in parameter space for each sample, and find that magnification and lensing contribute $\sim2-18\%$ of the total signal. As precision continues to improve, it will certainly be necessary to account for these effects in future direct IA measurements. Finally, we make equivalent measurements on a sample of Emission Line Galaxies (ELGs) from eBOSS at $z\sim 0.8$. We report a null detection, constraining the IA amplitude (assuming the nonlinear alignment model) to be $A_1=0.07^{+0.32}_{-0.42}$ ($|A_1|<0.78$ at $95\%$ CL).Comment: Submitted to MNRAS; 22 pages, 11 figure

SPT Clusters with DES and HST Weak Lensing. I. Cluster Lensing and Bayesian Population Modeling of Multi-Wavelength Cluster Datasets

We present a Bayesian population modeling method to analyze the abundance of galaxy clusters identified by the South Pole Telescope (SPT) with a simultaneous mass calibration using weak gravitational lensing data from the Dark Energy Survey (DES) and the Hubble Space Telescope (HST). We discuss and validate the modeling choices with a particular focus on a robust, weak-lensing-based mass calibration using DES data. For the DES Year 3 data, we report a systematic uncertainty in weak-lensing mass calibration that increases from 1\% at $z=0.25$ to 10\% at $z=0.95$, to which we add 2\% in quadrature to account for uncertainties in the impact of baryonic effects. We implement an analysis pipeline that joins the cluster abundance likelihood with a multi-observable likelihood for the SZ, optical richness, and weak-lensing measurements for each individual cluster. We validate that our analysis pipeline can recover unbiased cosmological constraints by analyzing mocks that closely resemble the cluster sample extracted from the SPT-SZ, SPTpol~ECS, and SPTpol~500d surveys and the DES Year~3 and HST-39 weak-lensing datasets. This work represents a crucial prerequisite for the subsequent cosmological analysis of the real dataset.Comment: submitted to PR

Consistent lensing and clustering in a low-S8 Universe with BOSS, DES Year 3, HSC Year 1, and KiDS-1000

We evaluate the consistency between lensing and clustering based on measurements from Baryon Oscillation Spectroscopic Survey combined with galaxy-galaxy lensing from Dark Energy Survey (DES) Year 3, Hyper Suprime-Cam Subaru Strategic Program (HSC) Year 1, and Kilo-Degree Survey (KiDS)-1000. We find good agreement between these lensing data sets. We model the observations using the DARK EMULATOR and fit the data at two fixed cosmologies: Planck (S8 = 0.83), and a Lensing cosmology (S8 = 0.76). For a joint analysis limited to large scales, we find that both cosmologies provide an acceptable fit to the data. Full utilization of the higher signal-to-noise small-scale measurements is hindered by uncertainty in the impact of baryon feedback and assembly bias, which we account for with a reasoned theoretical error budget. We incorporate a systematic inconsistency parameter for each redshift bin, A, that decouples the lensing and clustering. With a wide range of scales, we find different results for the consistency between the two cosmologies. Limiting the analysis to the bins for which the impact of the lens sample selection is expected to be minimal, for the Lensing cosmology, the measurements are consistent with A = 1; A = 0.91 ± 0.04 (A = 0.97 ± 0.06) using DES+KiDS (HSC). For the Planck case, we find a discrepancy: A = 0.79 ± 0.03 (A = 0.84 ± 0.05) using DES+KiDS (HSC). We demonstrate that a kinematic Sunyaev-Zeldovich-based estimate for baryonic effects alleviates some of the discrepancy in the Planck cosmology. This analysis demonstrates the statistical power of small-scale measurements; however, caution is still warranted given modelling uncertainties and foreground sample selection effects

Joint analysis of DES Year 3 data and CMB lensing from SPT and Planck I: Construction of CMB Lensing Maps and Modeling Choices

Joint analyses of cross-correlations between measurements of galaxy positions, galaxy lensing, and lensing of the cosmic microwave background (CMB) offer powerful constraints on the large-scale structure of the Universe. In a forthcoming analysis, we will present cosmological constraints from the analysis of such cross-correlations measured using Year 3 data from the Dark Energy Survey (DES), and CMB data from the South Pole Telescope (SPT) and Planck. Here we present two key ingredients of this analysis: (1) an improved CMB lensing map in the SPT-SZ survey footprint, and (2) the analysis methodology that will be used to extract cosmological information from the cross-correlation measurements. Relative to previous lensing maps made from the same CMB observations, we have implemented techniques to remove contamination from the thermal Sunyaev Zel'dovich effect, enabling the extraction of cosmological information from smaller angular scales of the cross-correlation measurements than in previous analyses with DES Year 1 data. We describe our model for the cross-correlations between these maps and DES data, and validate our modeling choices to demonstrate the robustness of our analysis. We then forecast the expected cosmological constraints from the galaxy survey-CMB lensing auto and cross-correlations. We find that the galaxy-CMB lensing and galaxy shear-CMB lensing correlations will on their own provide a constraint on $S_8=\sigma_8 \sqrt{\Omega_{\rm m}/0.3}$ at the few percent level, providing a powerful consistency check for the DES-only constraints. We explore scenarios where external priors on shear calibration are removed, finding that the joint analysis of CMB lensing cross-correlations can provide constraints on the shear calibration amplitude at the 5 to 10% level.Comment: 30 pages, 20 figures, To be submitted to PR