A critical review of South African child and youth resilience studies, 2009-2017

Abstract: In contexts of high levels of structural disadvantage, such as South Africa, resilience among children and youth becomes increasingly important to buffer children and youth from the negative effects of adversity. This article reports on a systematic review of research conducted in South Africa over the period 2009 to 2017 on the resilience of children and youth (ages 0 to 24) from the perspectives of young people themselves. It serves as a follow-up and refinement of an earlier publication in 2010. A total of 61 journal articles are reviewed. Four categories of social-ecological resilience-enablers emerge from these study, viz. personal, relational, structural and spiritual/cultural. Most of the resilience-enablers identified in these studies are in the personal and relational domains. Various reasons for this finding are discussed, and emerging recommendations for service professionals (particularly social worker and educational psychologists) and youth resilience researchers are advanced

Intra-Pelvic Migration of Sliding Hip Screw During Osteosynthesis of Hip Fracture: A Rare Avoidable Intraoperative Complication.

Hip fractures, which are common among old patients, are classified into two groups: intracapsular and extracapsular fractures. Extracapsular fractures can be treated with extramedullary implants [e.g. dynamic hip screw (DHS)] or intramedullary nails. Dynamic hip screw is the treatment of choice in stable pertrochanteric fractures. Intrapelvic migration of the sliding screw is a very rare complication

Comprehensive analysis of the start-up period of a full-scale drinking water biofilter provides guidance for optimization

Abstract. The use of biofilters to produce drinking water from anaerobic groundwater is widespread in some European countries. A major disadvantage of biofilters is the long start-up period required for virgin filter medium to become fully functional. Although individual aspects of biofilter start-up have previously been investigated, no comprehensive study in full-scale using inherent inoculation has previously been documented. A thorough investigation of a full-scale drinking water biofilter was carried out over 10 weeks of start-up. The many spatial and temporal changes taking place during start-up were documented using a holistic approach. In addition to collection of many samples over time (frequency) and space (filter depth), this study entailed the use of multiple sample media (water, backwash water and filter media) and multiple types of analyses (physical, chemical and microbiological). The decrease in filter effluent concentrations of individual substances to compliance levels followed a specific order that was shown to coincide with the spatial-temporal development of bacteria on the filter media. Due to the abiotic nature of the iron removal process, iron disappears first followed by substances that require growth of microorganisms: ammonium, with nitrite appearing briefly near the end of ammonium removal, then manganese. The thorough overall picture obtained by these efforts provides guidance for optimization and monitoring of the start-up. Guidance include to shorten the start-up by focusing on kick-start of the ammonium removal, to limit the monitoring burden to at-line measurements of ammonium in finished water samples supplemented with manual manganese measurements when ammonium removal is complete, and to improve filter design by isolating the removal processes in separate, smaller filters. </jats:p

Curing hemoglobinopathies : challenges and advances of conventional and new gene therapy approaches

Inherited hemoglobin disorders, including beta-thalassemia (BT) and sickle-cell disease (SCD), are the most common monogenic diseases worldwide, with a global carrier frequency of over 5%.1 With migration, they are becoming more common worldwide, making their management and care an increasing concern for health care systems. BT is characterized by an imbalance in the \u3b1/\u3b2-globin chain ratio, ineffective erythropoiesis, chronic hemolytic anemia, and compensatory hemopoietic expansion.1 Globally, there are over 25,000 births each year with transfusion-dependent thalassemia (TDT). The currently available treatment for TDT is lifelong transfusions and iron chelation therapy or allogenic bone marrow transplantation as a curative option. SCD affects 300 million people worldwide2 and severely impacts the quality of life of patients who experience unpredictable, recurrent acute and chronic severe pain, stroke, infections, pulmonary disease, kidney disease, retinopathy, and other complications. While survival has been dramatically extended, quality of life is markedly reduced by disease- and treatment-associated morbidity. The development of safe, tissue-specific and efficient vectors, and efficient gene-editing technologies has led to the development of several gene therapy trials for BT and SCD. However, the complexity of the approach presents its hurdles. Fundamental factors at play include the requirement for myeloablation on a patient with benign disease, the age of the patient, and the consequent bone marrow microenvironment. A successful path from proof-of-concept studies to commercialization must render gene therapy a sustainable and accessible approach for a large number of patients. Furthermore, the cost of these therapies is a considerable challenge for the health care system. While new promising therapeutic options are emerging,3,4 and many others are on the pipeline,5 gene therapy can potentially cure patients. We herein provide an overview of the most recent, likely potentially curative therapies for hemoglobinopathies and a summary of the challenges that these approaches entail

Vertebro-vertebral fistula presenting as a pulsatile tinnitus

Tinnitus is the perception of sound in the absence of a corresponding external acoustic stimulus, resulting in an estimated prevalence of 10% to 15% in adults. Tinnitus may be classified as pulsatile (PT) or continuous (non-PT), and may be subjective (heard only by the patient) or objective (also audible to the examiner). PT is usually related to vascular causes and is pulse synchronous (coinciding with the patient's heartbeat). PT is much less common affecting approximately 4% of patients with tinnitus, but unlike non-PT, usually has a specific identifiable cause. We present a case of a man without previous otological disease or head trauma, with a left-ear subjective PT. MR angiography detected a left vertebro-vertebral arteriovenous fistula, which was treated by endovascular embolisation with important symptomatic relief.info:eu-repo/semantics/publishedVersio

Comprehensive analysis of the start-up period of a full-scale drinking water biofilter provides guidance for optimization

The use of biofilters to produce drinking water from anaerobic groundwater is widespread in some European countries. A major disadvantage of biofilters is the long start-up period required for virgin filter medium to become fully functional. Although individual aspects of biofilter start-up have previously been investigated, no comprehensive study in full scale using inherent inoculation has previously been documented. A thorough investigation of a full-scale drinking water biofilter was carried out over 10 weeks of start-up. The many spatial and temporal changes taking place during start-up were documented using a holistic approach. In addition to collection of many samples over time (frequency) and space (filter depth), this study entailed the use of multiple sample media (water, backwash water and filter media) and multiple types of analyses (physical, chemical and microbiological). The decrease in filter effluent concentrations of individual substances to compliance levels followed a specific order that was shown to coincide with the spatiotemporal development of bacteria on the filter media. Due to the abiotic nature of the iron removal process, iron disappears at the earliest in the start-up period followed by substances that require growth of microorganisms. Ammonium disappears next, with nitrite appearing briefly near the end of ammonium removal, followed by manganese. The thorough overall picture obtained by these efforts provides guidance for optimization and monitoring of the start-up. Guidance for optimization includes shortening the start-up by focusing on kick-starting the ammonium removal; limiting the monitoring burden (at-line measurements of ammonium in finished water supplemented with manual manganese measurements when ammonium removal is complete); and improving filter design by isolating the removal processes in separate, smaller filters.</p

Um Ambiente para Apoio à Tradução Baseado em Conhecimento : Cstudo de Caso com Português-Libras

Esta dissertação apresenta uma proposta de tradução automática baseada em conhecimento, o projeto e a implementação de um sistema de autoria e uso de tradutores automatizados para apoio à tradução, tendo como estudo de caso a tradução de Português para Libras. Esse sistema possui um ambiente para manipulação dos elementos utilizados no processo de tradução automática e um para tradução automática de textos de uma língua-fonte, em forma de texto, para uma língua-alvo, em forma de texto, vídeo e/ou áudio. Os elementos utilizados no processo de tradução são exemplos de tradução da língua-fonte para a língua-alvo e regras de tradução inferidas considerando esses mesmos exemplos. Para isso, o conteúdo deste trabalho apresenta um estudo sobre tradução automática, apontando seus métodos e, brevemente, seus principais paradigmas, além de uma breve exposição sobre memória de tradução. Apresenta também um estudo sobre a definição de linguagens formais e inferência gramatical, apontando seus métodos e, brevemente, a especificação de problemas de inferência gramatical. Apresenta ainda os algoritmos de tradução e de inferência utilizados pelo sistema, bem como as estruturas de dados necessárias e resultados gerados por eles. Ao longo de todo o conteúdo, é possível observar alguns aspectos de usabilidade, navegabilidade, funcionalidade e complexidade do sistema gerado como produto final deste trabalho, um ambiente de apoio à tradução, baseado em exemplos e sintaxe

3D extension at plate boundaries accommodated by interacting fault systems

Complex patterns of normal faults with multiple orientations and/or highly curved shapes have been traditionally explained by successive tectonic phases of 2-dimensional deformation. Alternatively, multiple fault sets have been proposed to develop simultaneously and in orthorhombic symmetry during a single phase of 3-dimensional deformation. We use analogue models of normal faults to demonstrate that, without the influence of pre-existing structures, 3D extension is preferentially accommodated by the alternate, rather than simultaneous, development of faults with different trends. By means of stress-driven interactions, 3D deformation can be partitioned into coupled systems of normal faults, which display geometries commonly observed in tectonic settings affected by interacting plate boundaries. Under radial extension, deformation is accommodated by major curvilinear grabens coupled with minor perpendicular faults, resulting in the triple junctions of grabens observed in Afar. On the other hand, the alternate development of perpendicular faults accommodates synchronous bi-directional and mutually perpendicular extension, giving the same fault pattern observed in the Barents Sea rift-shear margin

3D Extension at Plate Boundaries Accommodated by Interacting Fault Systems

Complex patterns of normal faults with multiple orientations and/or highly curved shapes have been traditionally explained by successive tectonic phases of 2-dimensional deformation. Alternatively, multiple fault sets have been proposed to develop simultaneously and in orthorhombic symmetry during a single phase of 3-dimensional deformation. We use analogue models of normal faults to demonstrate that, without the influence of pre-existing structures, 3D extension is preferentially accommodated by the alternate, rather than simultaneous, development of faults with different trends. By means of stress-driven interactions, 3D deformation can be partitioned into coupled systems of normal faults, which display geometries commonly observed in tectonic settings affected by interacting plate boundaries. Under radial extension, deformation is accommodated by major curvilinear grabens coupled with minor perpendicular faults, resulting in the triple junctions of grabens observed in Afar. On the other hand, the alternate development of perpendicular faults accommodates synchronous bi-directional and mutually perpendicular extension, giving the same fault pattern observed in the Barents Sea rift-shear margin

Management of hypopharyngeal and laryngeal tumours:a 6-year review

info:eu-repo/semantics/publishedVersio