9,860 research outputs found
Mean first passage time analysis reveals rate-limiting steps, parallel pathways and dead ends in a simple model of protein folding
We have analyzed dynamics on the complex free energy landscape of protein
folding in the FOLD-X model, by calculating for each state of the system the
mean first passage time to the folded state. The resulting kinetic map of the
folding process shows that it proceeds in jumps between well-defined, local
free energy minima. Closer analysis of the different local minima allows us to
reveal secondary, parallel pathways as well as dead ends.Comment: 7 page
Binary morphological shape-based interpolation applied to 3-D tooth reconstruction
In this paper we propose an interpolation algorithm using a mathematical morphology morphing approach. The aim of this algorithm is to reconstruct the -dimensional object from a group of (n-1)-dimensional sets representing sections of that object. The morphing transformation modifies pairs of consecutive sets such that they approach in shape and size. The interpolated set is achieved when the two consecutive sets are made idempotent by the morphing transformation. We prove the convergence of the morphological morphing. The entire object is modeled by successively interpolating a certain number of intermediary sets between each two consecutive given sets. We apply the interpolation algorithm for 3-D tooth reconstruction
Deriving a systematic approach to changeable manufacturing system design
It has long been argued that Factories are long life and complex products. The complexity of designing factories, and their underlying manufacturing systems, is further amplified when dealing with continuously changing customer demands. At the same time, due to research fragmentation, little if any scientific explanations are available supporting and exploiting the paradigm that "factories are products". In order to address this weakness, this paper presents research results arising from a comparative analysis of systematic "product design" and "manufacturing system design" approaches. The contribution emerging from this research is an integrated systematic design approach to changeable manufacturing systems, based on scientific concepts founded upon product design theories, and is explained through a case study in the paper. This research is part of collaboration between the CERU University of Malta and IAO Fraunhofer aimed at developing a digital decision support tool for planning changeable manufacturing systems.peer-reviewe
Compact phases of polymers with hydrogen bonding
We propose an off-lattice model for a self-avoiding homopolymer chain with
two different competing attractive interactions, mimicking the hydrophobic
effect and the hydrogen bond formation respectively. By means of Monte Carlo
simulations, we are able to trace out the complete phase diagram for different
values of the relative strength of the two competing interactions. For strong
enough hydrogen bonding, the ground state is a helical conformation, whereas
with decreasing hydrogen bonding strength, helices get eventually destabilized
at low temperature in favor of more compact conformations resembling
-sheets appearing in native structures of proteins. For weaker hydrogen
bonding helices are not thermodynamically relevant anymore.Comment: 5 pages, 3 figures; revised version published in PR
Constrained dynamic control of traffic junctions
Excessive traffic in our urban environments has detrimental effects on our health, economy and standard of living. To mitigate this problem, an adaptive traffic lights signalling scheme is developed and tested in this paper. This scheme is based on a state space representation of traffic dynamics, controlled via a dynamic programme. To minimise implementation costs, only one loop detector is assumed at each link. The comparative advantages of the proposed system over optimal fixed time control are highlighted through an example. Results will demonstrate the flexibility of the system when applied to different junctions. Monte Carlo runs of the developed scheme highlight the consistency and repeatability of these results.peer-reviewe
Community, work and family in diverse contexts and changing times
The 8th International Community, Work and Family conference took place in Malta at the Valletta campus of the University of Malta between the 23rd to the 25th May 2019. In a pre-COVID-19 world with no traveling restrictions, the conference brought together over 100 experts, academics, and students from a broad range of countries and disciplines to focus on the theme of Community, Work and Family in Diverse Contexts and Changing Times.
The research presented during the conference highlights some of the challenges that communities, organizations and families are facing in the twenty-first century across diverse and rapidly changing contexts. The topics presented spanned from broad studies that analyze the work-life interface of well-studied groups such as fathers and mothers, to other clusters that are generally less well-researched such as the police and the military, migrants, solo entrepreneurs, the LGBTIQ community, and those who work with people with special needs.
The recurrent theme of the gendered division of labor and work-life measures was discussed by various researchers, as were the issues of flexible work, family policy, and the impact of technology. It was refreshing to note that various researchers focused on the issue of community as a source of support, whilst others explored how peer, supervisor and management support impacts work-life issues. Overall, the conference provided a diverse and rich range of scholarly material upon which to develop this special issue for Community, Work & Family. [...
Scale Free Cluster Distributions from Conserving Merging-Fragmentation Processes
We propose a dynamical scheme for the combined processes of fragmentation and
merging as a model system for cluster dynamics in nature and society displaying
scale invariant properties. The clusters merge and fragment with rates
proportional to their sizes, conserving the total mass. The total number of
clusters grows continuously but the full time-dependent distribution can be
rescaled over at least 15 decades onto a universal curve which we derive
analytically. This curve includes a scale free solution with a scaling exponent
of -3/2 for the cluster sizes.Comment: 4 pages, 3 figure
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