The culture and economic attributes of pusostreet food industry: Basis for a contextualized framework of pusoteaching model

Recognizing the cultural and economic attributes of pusois an essential part of Cebuanostreet food culture and industry that serves as the basis for a contextualized framework of pusoteaching model. The study used a grounded theorydesign with interviews among 18 key research participants. The attributes of pusomirror a social identity in Cebu’s street food industry and culture. Its orientation as a ritual object has shifted to a pragmatic orientation reflecting Cebu city’s fast paced-life. Its new identification creates a changing perspective; its characteristics remain integral to the Cebuano cultural identity; its rapid changes serve as one of the basesfor local government units to regulate the industry’s management operations; and serve as a framework in the creation and dissemination of a contextualizedteaching framework known as the Contextualized PUSO Teaching Model (CPTM). This innovative and culture-based teaching model addresses all teachers in academia to develop a sufficient grounding of cultural orientation and traditions that may warrant best learning opportunities

Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis

CLN7 neuronal ceroid lipofuscinosis is an inherited lysosomal storage neurodegenerative disease highly prevalent in children. CLN7/MFSD8 gene encodes a lysosomal membrane glycoprotein, but the biochemical processes affected by CLN7-loss of function are unexplored thus preventing development of potential treatments. Here, we found, in the Cln7∆ex2 mouse model of CLN7 disease, that failure in autophagy causes accumulation of structurally and bioenergetically impaired neuronal mitochondria. In vivo genetic approach reveals elevated mitochondrial reactive oxygen species (mROS) in Cln7∆ex2 neurons that mediates glycolytic enzyme PFKFB3 activation and contributes to CLN7 pathogenesis. Mechanistically, mROS sustains a signaling cascade leading to protein stabilization of PFKFB3, normally unstable in healthy neurons. Administration of the highly selective PFKFB3 inhibitor AZ67 in Cln7∆ex2 mouse brain in vivo and in CLN7 patients-derived cells rectifies key disease hallmarks. Thus, aberrant upregulation of the glycolytic enzyme PFKFB3 in neurons may contribute to CLN7 pathogenesis and targeting PFKFB3 could alleviate this and other lysosomal storage diseases

New national and regional bryophyte records, 69

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An Overview of the Potential Environmental Impacts of Large Scale Microalgae Cultivation

Cultivation of microalgae for applications such as fuel, food, pharmaceuticals and farming is a rapidly developing area of research and investment. Whilst microalgae promises to deliver many environmental benefits compared with existing biofuel technology, there are also issues to overcome in relation to wastewater management, emissions control, land use change and responsible development of genetically modified organisms. This review seeks to highlight both the positive and negative impacts of microalgae cultivation, focusing on impacts to the aquatic, atmospheric and terrestrial biospheres that may occur and would need to be managed should the microalgae cultivation industry continue to grow

Perancangan Alat Rehabilitasi Pergelangan Tangan Pasien Pasca Stroke yang Digerakkan Motor Servo

Stroke merupakan kondisi yang terjadi ketika pasokan darah ke otak terganggu atau berkurang akibat penyumbatan (stroke iskemik) atau pecahnya pembuluh darah (stroke hemoragik). Seseorang yang mengidap penyakit stroke akan mengalami gangguan pada otak yang menyebabkan tidak bisa menjalani aktifitas seperti manusia normal. Pada umumnya, pasien stroke mengalami kelumpuhan pada beberapa bagian tubuh, seperti tangan, kaki, bahkan wajah. Dengan berkembangnya teknologi pada era ini, penyakit stroke bisa disembuhkan dengan berbagai metode dari para ahli kesehatan. Sembuh yang dimaksudkan adalah hasil dari penanganan untuk pembuluh darah yang tersumbat atau pecah. Namun, kelumpuhan yang dialami penderita tidak bisa langsung kembali seperti semula, membutuhkan beberapa terapi atau latihan untuk menstimulus otot pada tangan, kaki, ataupun wajah. Pada penelitian ini, difokuskan untuk terapi pada pergelangan tangan yang mempunyai sendi putar. Untuk pembuatan konsep alat rehabilitasi pergelangan tangan yang digerakkan motor servo ini diperlukan beberapa kajian pada produk-produk yang sudah ada. Dari pengkajian produk eksisting, akan disusun daftar kebutuhan atau List of Requirements yang berguna untuk membuat konsep desain alat rehabilitasi ini. Diharapkan pada penelitian ini, diperoleh alat rehabilitasi pergelangan tangan otomatis yang bisa membantu pasien pasca stroke dalam menjalani proses rehabilitasi

THE RESPONSE TO P-DERIVED FROM PHOSPHATE ROCK AND TSP BY CROPS GROWN IN A SIMULATED CROP ROTATION SYSTEM

ABSTRACT THE RESPONSE TO P-DERIVED FROM PHOSPHATE ROCK AND TSP BY CROPS GROWN IN A SIMULATED CROP ROTATION SYSTEM. A green house experiment was carried out on a simulated crop rotation system of upland rice-soybeanmungbean to determine the effect of P-derived from different phosphate rock (PR) sources and TSP using 32 P. The data obtained reveal that all the P-sources has a significant effect on the growth of all the three crops, expressed in dry weight, % P-total and total P-uptake (mg P pot -1 ). For the P-source it was shown that % P-derived from PR/TSP and their uptake (mg P pot -1 ) was quite high, showing that the PR s applied were of good reactivity. The residue of the PR s has also still a good effect on plant growth than that of TSP. The efficiency of PR s was far below that of TSP. This apparently was due to the high rate of application, ten times the rate of TSP

Recent HIV-1 outbreak among intravenous drug users in Romania: Evidence for cocirculation of CRF14-BG and Subtype F1 Strains

Since 2011, Romania has faced an HIV outbreak among injecting drug users (IDUs). Our aim was to identify and describe clinical and epidemiological patterns of this outbreak. A cross-sectional study enrolled 138 IDUs diagnosed with HIV infection between 2011 and 2013 with 58 sexually infected individuals included as the control group. The IDUs had a long history of heroin abuse (10 years) and a recent history of new psychostimulant injection (3-4 years). Classical epidemiological data and molecular techniques were used to describe the transmission dynamics. A high prevalence of hepatitis C virus (HCV) coinfection was noted (98.6%) compared to the control group (10.3%) (p<0.001). IDUs had initially been infected with HCV. HIV infection was more recent, linked to starting injecting stimulants. HIV subtype analysis showed a predominance of the local F1 strain in both IDUs and sexually infected patients; in IDUs it also identified 28 CRF14-BG recombinants and six unique recombinant forms (URFs) between F1 and CRF14-BG. A few patients from both risk groups were infected with subtype B. Among IDUs, CRF14-BG was associated with a lower CD4 cell count and more advanced stages of disease, which correlated with CXCR4 tropism. Phylogenetic analysis revealed the spread of HIV through three major IDU clusters of recent date. Among IDUs with CRF14-BG, some reported travel abroad (Spain, Greece). By identifying clusters of IDUs with related viruses, molecular epidemiologic methods provide valuable information on patterns of HIV transmission that can be useful in planning appropriate harm reduction interventions. © Copyright 2015, Mary Ann Liebert, Inc. 2015