Human malarial disease: a consequence of inflammatory cytokine release

Malaria causes an acute systemic human disease that bears many similarities, both clinically and mechanistically, to those caused by bacteria, rickettsia, and viruses. Over the past few decades, a literature has emerged that argues for most of the pathology seen in all of these infectious diseases being explained by activation of the inflammatory system, with the balance between the pro and anti-inflammatory cytokines being tipped towards the onset of systemic inflammation. Although not often expressed in energy terms, there is, when reduced to biochemical essentials, wide agreement that infection with falciparum malaria is often fatal because mitochondria are unable to generate enough ATP to maintain normal cellular function. Most, however, would contend that this largely occurs because sequestered parasitized red cells prevent sufficient oxygen getting to where it is needed. This review considers the evidence that an equally or more important way ATP deficency arises in malaria, as well as these other infectious diseases, is an inability of mitochondria, through the effects of inflammatory cytokines on their function, to utilise available oxygen. This activity of these cytokines, plus their capacity to control the pathways through which oxygen supply to mitochondria are restricted (particularly through directing sequestration and driving anaemia), combine to make falciparum malaria primarily an inflammatory cytokine-driven disease

An entropy approach to size and variance heterogeneity

In this paper, we investigate the effect of bank size differences on cost efficiency heterogeneity using a heteroskedastic stochastic frontier model. This model is implemented by using an information theoretic maximum entropy approach. We explicitly model both bank size and variance heterogeneity simultaneously. We find that non-performing loans, federal insurance premium, legal expenses and director fees drive bank inefficiency as the bank becomes larger. Moral hazard, bank management and a “too big to fail” doctrine are likely explanations for the results from this study. Keywords Commercial Banks . Heteroskedasticity . Cost Frontier . Maximum Entrop

Predicting Contradiction Intensity: Low, Strong or Very Strong?

International audienceReviews on web resources (e.g. courses, movies) become increasingly exploited in text analysis tasks (e.g. opinion detection, controversy detection). This paper investigates contradiction intensity in reviews exploiting different features such as variation of ratings and variation of polarities around specific entities (e.g. aspects, topics). Firstly, aspects are identified according to the distributions of the emotional terms in the vicinity of the most frequent nouns in the reviews collection. Secondly, the polarity of each review segment containing an aspect is estimated. Only resources containing these aspects with opposite polarities are considered. Finally, some features are evaluated, using feature selection algorithms, to determine their impact on the effectiveness of contradiction intensity detection. The selected features are used to learn some state-of-the-art learning approaches. The experiments are conducted on the Massive Open Online Courses data set containing 2244 courses and their 73,873 reviews, collected from coursera.org. Results showed that variation of ratings, variation of polarities, and reviews quantity are the best predictors of contradiction intensity. Also, J48 was the most effective learning approach for this type of classification

Text Analytics in Social Media

International audienc