Sächsisches Berg- und Hüttenwesen digital: Universitätsbibliothek Freiberg startet Digitale Bibliothek mit Goobi und plant weitere Kollektionen

Nach umfangreichen Vorarbeiten hat die UB Freiberg im Herbst 2013 mit dem Aufbau einer eigenen Digitalen Bibliothek begonnen. Passend zum Thema des Wissenschaftsjahres 2014 „Die Digitale Gesellschaft“ werden bislang versteckte oder gar nicht öffentlich zugängliche Bestände strukturiert und in einer nutzerfreundlichen Oberfläche der Öffentlichkeit präsentiert. Mit dem Know-How der SLUB Dresden sowie der Möglichkeit ihre Entwicklungen und Infrastruktur mit zu nutzen, konnte das Projekt in relativ kurzer Zeit realisiert werden. Für die Digitalisierung und Präsentation der Freiberger Bestände wird die Open-Source-Software Goobi genutzt

Constructive approach to limiting periodic orbits with exponential and power law dynamics

In dynamical systems limit cycles arise as a result of a Hopf bifurcation, after a control parameter has crossed its critical value. In this study we present a constructive method to produce dissipative dynamics which lead to stable periodic orbits as time grows, with predesigned transient dynamics. Depending on the construction method a) the limiting orbit can be a regular circle, an ellipse or a more complex closed orbit and b) the approach to the limiting orbit can follow an exponential law or a power law. This technique allows to design nonlinear models of dynamical systems with desired (exponential or power law) relaxation properties.Comment: 17 pages, 6 figure

A mixed methods feasibility study to evaluate the use of a low-intensity, nurse-delivered cognitive behavioural therapy for the treatment of irritable bowel syndrome

Introduction: Irritable bowel syndrome (IBS) is characterised by symptoms such as abdominal pain, constipation, diarrhoea and bloating. These symptoms impact on health-related quality of life, result in excess service utilisation and are a significant burden to healthcare systems. Certain mechanisms which underpin IBS can be explained by a biopsychosocial model which is amenable to psychological treatment using techniques such as cognitive behavioural therapy (CBT). While current evidence supports CBT interventions for this group of patients, access to these treatments within the UK healthcare system remains problematic. Methods and analysis: A mixed methods feasibility randomised controlled trial will be used to assess the feasibility of a low-intensity, nurse-delivered guided self-help intervention within secondary care gastrointestinal clinics. A total of 60 participants will be allocated across four treatment conditions consisting of: high-intensity CBT delivered by a fully qualified cognitive behavioural therapist, low-intensity guided self-help delivered by a registered nurse, self-help only without therapist support and a treatment as usual control condition. Participants from each of the intervention arms of the study will be interviewed in order to identify potential barriers and facilitators to the implementation of CBT interventions within clinical practice settings. Quantitative data will be analysed using descriptive statistics only. Qualitative data will be analysed using a group thematic analysis.N/

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

Evidence synthesis to inform model-based cost-effectiveness evaluations of diagnostic tests: a methodological systematic review of health technology assessments

Background: Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from various sources to be incorporated and enable cost-effectiveness estimates to be made beyond the duration of available study data. To parameterize a health-economic model fully, all the ways a test impacts on patient health must be quantified, including but not limited to diagnostic test accuracy. Methods: We assessed all UK NIHR HTA reports published May 2009-July 2015. Reports were included if they evaluated a diagnostic test, included a model-based health economic evaluation and included a systematic review and meta-analysis of test accuracy. From each eligible report we extracted information on the following topics: 1) what evidence aside from test accuracy was searched for and synthesised, 2) which methods were used to synthesise test accuracy evidence and how did the results inform the economic model, 3) how/whether threshold effects were explored, 4) how the potential dependency between multiple tests in a pathway was accounted for, and 5) for evaluations of tests targeted at the primary care setting, how evidence from differing healthcare settings was incorporated. Results: The bivariate or HSROC model was implemented in 20/22 reports that met all inclusion criteria. Test accuracy data for health economic modelling was obtained from meta-analyses completely in four reports, partially in fourteen reports and not at all in four reports. Only 2/7 reports that used a quantitative test gave clear threshold recommendations. All 22 reports explored the effect of uncertainty in accuracy parameters but most of those that used multiple tests did not allow for dependence between test results. 7/22 tests were potentially suitable for primary care but the majority found limited evidence on test accuracy in primary care settings. Conclusions: The uptake of appropriate meta-analysis methods for synthesising evidence on diagnostic test accuracy in UK NIHR HTAs has improved in recent years. Future research should focus on other evidence requirements for cost-effectiveness assessment, threshold effects for quantitative tests and the impact of multiple diagnostic tests

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

Sächsisches Berg- und Hüttenwesen digital: Universitätsbibliothek Freiberg startet Digitale Bibliothek mit Goobi und plant weitere Kollektionen

Nach umfangreichen Vorarbeiten hat die UB Freiberg im Herbst 2013 mit dem Aufbau einer eigenen Digitalen Bibliothek begonnen. Passend zum Thema des Wissenschaftsjahres 2014 „Die Digitale Gesellschaft“ werden bislang versteckte oder gar nicht öffentlich zugängliche Bestände strukturiert und in einer nutzerfreundlichen Oberfläche der Öffentlichkeit präsentiert. Mit dem Know-How der SLUB Dresden sowie der Möglichkeit ihre Entwicklungen und Infrastruktur mit zu nutzen, konnte das Projekt in relativ kurzer Zeit realisiert werden. Für die Digitalisierung und Präsentation der Freiberger Bestände wird die Open-Source-Software Goobi genutzt

Sächsisches Berg- und Hüttenwesen digital: Universitätsbibliothek Freiberg startet Digitale Bibliothek mit Goobi und plant weitere Kollektionen

Nach umfangreichen Vorarbeiten hat die UB Freiberg im Herbst 2013 mit dem Aufbau einer eigenen Digitalen Bibliothek begonnen. Passend zum Thema des Wissenschaftsjahres 2014 „Die Digitale Gesellschaft“ werden bislang versteckte oder gar nicht öffentlich zugängliche Bestände strukturiert und in einer nutzerfreundlichen Oberfläche der Öffentlichkeit präsentiert. Mit dem Know-How der SLUB Dresden sowie der Möglichkeit ihre Entwicklungen und Infrastruktur mit zu nutzen, konnte das Projekt in relativ kurzer Zeit realisiert werden. Für die Digitalisierung und Präsentation der Freiberger Bestände wird die Open-Source-Software Goobi genutzt

CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity

AbstractThe NADPH oxidases are important transmembrane proteins producing reactive oxygen species (ROS). Within the Nox family, different modes of activation can be discriminated. Nox1-3 are dependent on different cytosolic subunits, Nox4 seems to be constitutively active and Nox5 is directly activated by calcium. With the exception of Nox5, all Nox family members are thought to depend on the small transmembrane protein p22phox. With the discovery of the CRISPR/Cas9-system, a tool to alter genomic DNA sequences has become available. So far, this method has not been widely used in the redox community. On such basis, we decided to study the requirement of p22phox in the Nox complex using CRISPR/Cas9-mediated knockout. Knockout of the gene of p22phox, CYBA, led to an ablation of activity of Nox4 and Nox1 but not of Nox5. Production of hydrogen peroxide or superoxide after knockout could be rescued with either human or rat p22phox, but not with the DUOX-maturation factors DUOXA1/A2. Furthermore, different mutations of p22phox were studied regarding the influence on Nox4-dependent H2O2 production. P22phox Q130* and Y121H affected maturation and activity of Nox4. Hence, Nox5-dependent O2•− production is independent of p22phox, but native p22phox is needed for maturation of Nox4 and production of H2O2