Estimating the mass of CMEs from the analysis of EUV dimmings

Context. Reliable estimates of the mass of coronal mass ejections (CMEs) are required to quantify their energy and predict how they affect space weather. When a CME propagates near the observer's line of sight, these tasks involve considerable errors, which motivated us to develop alternative means for estimating the CME mass. Aims. We aim at further developing and testing a method that allows estimating the mass of CMEs that propagate approximately along the observer's line of sight. Methods. We analyzed the temporal evolution of the mass of 32 white-light CMEs propagating across heliocentric heights of 2.5-15 R, in combination with that of the mass evacuated from the associated low coronal dimming regions. The mass of the white-light CMEs was determined through existing methods, while the mass evacuated by each CME in the low corona was estimated using a recently developed technique that analyzes the dimming in extreme-UV (EUV) images. The combined white-light and EUV analyses allow the quantification of an empirical function that describes the evolution of CME mass with height. Results. The analysis of 32 events yielded reliable estimates of the masses of front-side CMEs. We quantified the success of the method by calculating the relative error with respect to the mass of CMEs determined from white-light STEREO data, where the CMEs propagate close to the plane of sky. The median for the relative error in absolute values is ≈30%; 75% of the events in our sample have an absolute relative error smaller than 51%. The sources of uncertainty include the lack of knowledge of piled-up material, subsequent additional mass supply from the dimming region, and limitations in the mass-loss estimation from EUV data. The proposed method does not rely on assumptions of CME size or distance to the observer's plane of sky and is solely based on the determination of the mass that is evacuated in the low corona. It therefore represents a valuable tool for estimating the mass of Earth-directed events.Fil: López, F. M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Cremades Fernandez, Maria Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Tecnológica Nacional; ArgentinaFil: Balmaceda, Laura Antonia. George Mason University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Nuevo, Federico Alberto. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Vásquez, A. M.. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; Argentina. Universidad Nacional de Tres de Febrero; Argentin

Firm and industry effects on small, medium-sized and large firms’ performance

This paper examines whether or not the relative importance of the firm and industry effects in explaining performance variations is the same regardless of the firm size. In relation to size, we think that there has been particular neglect of studying medium-sized firms separately from SMEs in general. That is why we study separately large, medium-sized and small firms. We also contribute to knowledge on the firm-industry debate testing empirically both effects distinguishing the firms by size according to a standard classification in the EU. Our results show that the performances of large and small firms are mainly explained by the firm effect, albeit for different reasons, while the performance of medium-sized firms is explained primarily by the industry effect

Artritis séptica de rodilla por Streptococcus agalactiae: presentación de un caso y revisión de la literatura

Se describe un caso de artritis séptica de rodilla en un paciente diabético de 69 años. En el momento de la presentación se hallaba sometido a curas locales de una úlcera crónica en el mismo miembro y a antibioterapia oral inespecífica por supuesta infección urinaria. En el cultivo del líquido sinovial se identificó un Streptococcus agalactiae (Estreptococo del grupo B). La infección no remitió con antibioterapia intravenosa electiva e irrigación-aspiración articular repetidas, requiriendo desbridamiento quirúrgico y sinovectomía. A pesar de instaurarse un programa de rehabilitación intensiva la rodilla evolucionó a la rigidez. Se revisa la literatura al respecto, destacando la asociación de artritis por estreptococos del grupo B con pacientes diabéticos portadores de úlceras cutáneas crónicas, así como la potencial gravedad de estas infecciones.This report describes a case of knee septic arthritis in a 69-year-old diabetic patient. At the time of admission he was receiving local treatment for a chronic skin ulcer in the same extremity and inespecific oral antibiotherapy because of an urinary tract infection. Synovial fluid cultures showed a Streptococcus agalactiae (group B streptococcus). The infection had no response to specific parenteral antibiotherapy and repeated joint irrigations-aspirations, and therefore surgical desbridement and synovectomy was required. Despite of an intensive rehabilitation program, the affected knee developed ankylosis. In a review of literature, it is remarkable the association between group B streptococcal arthritis and chronic skin ulcers in diabetic patients and the potential severity of these infections

Praxis farmacéutica en la proposición Chirurgica de Vaca de Alfaro (II)

En un trabajo precedente publicado en esta revista, se hizo un estudio crítico de los dos libros que conforman la «Proposición Chirurgica» de Vaca de Alfaro, médico cordobés del s. XVII. Ambos libros, se ocupan de la curación de los heridos de cabeza y el segundo contiene además un a modo de antidotario. En la primera parte se analizó el contenido de esta obra, fundamentalmente la praxis farmacéutica que en ella se refleja. La presente publicación recoge en índices las preparaciones farmacéuticas y los simples que aparecen en el antidotario del segundo libro

TLR4 and NLRP3 Caspase 1- IL-1β- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease

Hemodynamic collapse and myocardial dysfunction are among the major causes ofdeath in severe sepsis. The purpose of this study was to assess the role played by TLR4and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after highgradepolymicrobial sepsis. We performed the colon ascendens stent peritonitis (CASP)surgery in Tlr4-/-, Nlrp3-/- and caspase-1-/- mice. We also assessed for the first time theelectrical heart function in the CASP model. The QJ interval was increased in wild-typeC57BL/6J mice after CASP when compared to sham controls, a result paralleled by anincrease in the cardiac action potential duration (APD). The decreases in ejectionfraction (EF), left-ventricle end diastolic volume (LVEDV), stroke volume, and cardiacoutput found after CASP were similar among all groups of mice. Similar heart responsewas found when Nlrp3-/- mice were submitted to high-grade CLP. Despite developingcardiac dysfunction similar to wild-types after CASP, Nlrp3-/- mice had reducedcirculating levels of IL-1β, IL-6 and TNF-α. Our results demonstrate that the geneticablation of Tlr4, Nlrp3, and caspase-1 does not prevent the cardiac dysfunction, despitepreventing the increase in pro-inflammatory cytokines, indicating that these are notfeasible targets to therapy in high-grade sepsis.Fil: López Alarcón, Maria Micaela. Universidade Federal do Rio de Janeiro; BrasilFil: Fernandez Ruocco, Maria Julieta. Universidade Federal do Rio de Janeiro; BrasilFil: Ferreira, Fabiano. Universidade Federal do Rio de Janeiro; BrasilFil: Paula Neto, Heitor A.. Universidade Federal do Rio de Janeiro; BrasilFil: Sepúlveda, Marisa Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; ArgentinaFil: Vila Petroff, Martin Gerarde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; ArgentinaFil: Carvalho, Adriana Bastos. Universidade Federal do Rio de Janeiro; BrasilFil: Peroba Ramos, Isalira. Universidade Federal do Rio de Janeiro; BrasilFil: Branda, Hugo Justino. Universidade Federal do Rio de Janeiro; BrasilFil: Neto Paiva, Claudia. Universidade Federal do Rio de Janeiro; BrasilFil: Medei, Emiliano. Universidade Federal do Rio de Janeiro; Brasi

ArchDB 2014:Structural classification of loops in proteins

The function of a protein is determined by its three-dimensional structure, which is formed by regular (i.e. β-strands and α-helices) and non-periodic structural units such as loops. Compared to regular structural elements, non-periodic, non-repetitive conformational units enclose a much higher degree of variability—raising difficulties in the identification of regularities, and yet represent an important part of the structure of a protein. Indeed, loops often play a pivotal role in the function of a protein and different aspects of protein folding and dynamics. Therefore, the structural classification of protein loops is an important subject with clear applications in homology modelling, protein structure prediction, protein design (e.g. enzyme design and catalytic loops) and function prediction. ArchDB, the database presented here (freely available at http://sbi.imim.es/archdb), represents such a resource and has been an important asset for the scientific community throughout the years. In this article, we present a completely reworked and updated version of ArchDB. The new version of ArchDB features a novel, fast and user-friendly web-based interface, and a novel graph-based, computationally efficient, clustering algorithm. The current version of ArchDB classifies 149,134 loops in 5739 classes and 9608 subclasses

Relationship Between the Quorum Network (Sensing/Quenching) and Clinical Features of Pneumonia and Bacteraemia Caused by A. baumannii

Acinetobacter baumannii (Ab) is one of the most important pathogens associated with nosocomial infections, especially pneumonia. Interest in the Quorum network, i.e., Quorum Sensing (QS)/Quorum Quenching (QQ), in this pathogen has grown in recent years. The Quorum network plays an important role in regulating diverse virulence factors such as surface motility and bacterial competition through the type VI secretion system (T6SS), which is associated with bacterial invasiveness. In the present study, we investigated 30 clinical strains of A. baumannii isolated in the “II Spanish Study of A. baumannii GEIH-REIPI 2000-2010” (Genbank Umbrella Bioproject PRJNA422585), a multicentre study describing the relationship between the Quorum network in A. baumannii and the development of pneumonia and associated bacteraemia. Expression of the aidA gene (encoding the AidA protein, QQ enzyme) was lower (P < 0.001) in strains of A. baumannii isolated from patients with bacteraemic pneumonia than in strains isolated from patients with non-bacteraemic pneumonia. Moreover, aidA expression in the first type of strain was not regulated in the presence of environmental stress factors such as the 3-oxo-C12-HSL molecule (substrate of AidA protein, QQ activation) or H2O2 (inhibitor of AidA protein, QS activation). However, in the A. baumannii strains isolated from patients with non-bacteraemic pneumonia, aidA gene expression was regulated by stressors such as 3-oxo-C12-HSL and H2O2. In an in vivo Galleria mellonella model of A. baumannii infection, the A. baumannii ATCC 17978 strain was associated with higher mortality (100% at 24 h) than the mutant, abaI-deficient, strain (carrying a synthetase enzyme of Acyl homoserine lactone molecules) (70% at 24 h). These data suggest that the QS (abaR and abaI genes)/QQ (aidA gene) network affects the development of secondary bacteraemia in pneumonia patients and also the virulence of A. baumannii.National Plan for Scientific ResearchTechnological Development and Innovation PI16/01163ISCIII-Deputy General Directorate for Evaluation and Promotion of Research-European Regional Development Fund A way of Making EuropeInstituto de Salud Carlos IIIMiguel Servet Research Programme SERGAS and ISCIIIXunta de Galicia (GAIN, Axencia de Innovación