Cuidar el patrimonio cultural para preservar nuestra historia

Pieces of cultural and artistic interest, lead us to understand ways of life that document centuries of shared experiences with other times and spaces worthy of analysis in order to know the development of the human being, from the premises offered by the History of Art. Art entails the need of documentation, maintenance, divulgation and enjoyment for its transmission to the future. Its preservation guarantees a good condition for it and the restorer-conservator is the professional at the service of society for its defence and protection.Las piezas de interés cultural y artístico, nos llevan a comprender formas de vida que documentan siglos de experiencias compartidas con otros tiempos y espacios dignas de análisis para conocer el desarrollo del humano, desde las premisas que nos ofrece la Historia del Arte. El arte exige la necesidad de documentación, mantenimiento, divulgación y disfrute para la transmisión al futuro. Su preservación nos garantiza el buen estado y es el restaurador-conservador el profesional al servicio de la sociedad para su defensa y protección

Taking care of our cultural heritage to preserve our history

Las piezas de interés cultural y artístico, nos llevan a comprender formas de vida que documentan siglos de experiencias compartidas con otros tiempos y espacios dignas de análisis para conocer el desarrollo del humano, desde las premisas que nos ofrece la Historia del Arte. El arte exige la necesidad de documentación, mantenimiento, divulgación y disfrute para la transmisión al futuro. Su preservación nos garantiza el buen estado y es el restaurador-conservador el profesional al servicio de la sociedad para su defensa y protección.Pieces of cultural and artistic interest, lead us to understand ways of life that document centuries of shared experiences with other times and spaces worthy of analysis in order to know the development of the human being, from the premises offered by the History of Art. Art entails the need of documentation, maintenance, divulgation and enjoyment for its transmission to the future. Its preservation guarantees a good condition for it and the restorer-conservator is the professional at the service of society for its defence and protection

Razlike u enzimskim aktivnostima u tkivima šarana (Cyprinus carpio L.) kao mogući biološki pokazatelji izloženosti pesticidu metomilu

This study investigated the influence of the pesticide methomyl on different enzymatic activities in carp. The fish were exposed to a sub-lethal concentration (0.34 mg L-1) of methomyl for 15 days. On days 4 and 15, catalase (CAT) and glutathione-S-transferase (GST) activities were measured in the liver and gills. Acetylcholinesterase (AChE) activity in brain and muscle was also determined. Liver catalase activity slightly increased in exposed fish when compared to controls, but it was statistically significant only at the beginning of the experiment. No changes in CAT activity in the gills of exposed and control animals were observed (mean values were in the range 10.7-11.7 nmol min-1 per mg of protein). Liver GST activity was slightly inhibited in the exposed animals at the beginning of the study; however, it was significantly inhibited in the gills. Brain AChE activity was diminished throughout the experiment and significantly decreased after 96 h of exposure compared to controls (0.041 vs. 0.075 nmol min-1 per mg of protein; p<0.001). Our findings suggest that CAT, GST, and AChE are reliable biomarkers of effect after exposure to methomyl.Istražen je utjecaj pesticida metomila na razine enzimskih aktivnosti u tkivima šarana izloženih subletalnoj koncentraciji od 0,34 mg L-1 tijekom 15 dana. Nakon 4 i 15 dana u jetrima i škrgama pokusnih životinja izmjerene su aktivnosti katalaze i glutation S-transferaze (GST), a aktivnost acetilkolinesteraze (AChE) u mozgu i mišićima. Aktivnost katalaze u jetrima blago se smanjila u izloženih riba u usporedbi s kontrolnom skupinom, no to je smanjenje bilo statistički značajno tek na početku pokusa. Istovremeno nisu zamijećene značajne promjene u aktivnosti katalaze u škrgama izloženih i kontrolnih riba (srednje vrijednosti bile su u rasponu 10,7-11,7 nmol min-1 po miligramu proteina. Dok je aktivnost enzima GST u jetrima izloženih riba bila tek blago inhibirana na početku pokusa, u škrgama je utvrđena značajna inhibicija. Aktivnost acetilkolinesteraze u mozgu s vremenom se smanjivala i pokazala značajan pad nakon 96 sati izloženosti (0,041 vs. 0,075 nmol min-1 po miligramu proteina; p<0.001). Rezultati upućuju na zaključak da su katalaza, GST i AChE pouzdani biološki pokazatelji učinka izloženosti metomilu

Los medios locales y la rentabilidad. Estudio de casos digitales en Europa

Esta investigación ha sido financiada por el VI PPIT-US (Plan Propio de Investigación y Transferencia de la Universidad de Sevilla).Universidad de Sevilla VI PPIT-U

CPAMD8 loss-of-function underlies non-dominant congenital glaucoma with variable anterior segment dysgenesis and abnormal extracellular matrix

Abnormal development of the ocular anterior segment may lead to a spectrum of clinical phenotypes ranging from primary congenital glaucoma (PCG) to variable anterior segment dysgenesis (ASD). The main objective of this study was to identify the genetic alterations underlying recessive congenital glaucoma with ASD (CG-ASD). Next-generation DNA sequencing identified rare biallelic CPAMD8 variants in four patients with CG-ASD and in one case with PCG. CPAMD8 is a gene of unknown function and recently associated with ASD. Bioinformatic and in vitro functional evaluation of the variants using quantitative reverse transcription PCR and minigene analysis supported a loss-of-function pathogenic mechanism. Optical and electron microscopy of the trabeculectomy specimen from one of the CG-ASD cases revealed an abnormal anterior chamber angle, with altered extracellular matrix, and apoptotic trabecular meshwork cells. The CPAMD8 protein was immunodetected in adult human ocular fluids and anterior segment tissues involved in glaucoma and ASD (i.e., aqueous humor, non-pigmented ciliary epithelium, and iris muscles), as well as in periocular mesenchyme-like cells of zebrafish embryos. CRISPR/Cas9 disruption of this gene in F0 zebrafish embryos (96 hpf) resulted in varying degrees of gross developmental abnormalities, including microphthalmia, pharyngeal maldevelopment, and pericardial and periocular edemas. Optical and electron microscopy examination of these embryos showed iridocorneal angle hypoplasia (characterized by altered iris stroma cells, reduced anterior chamber, and collagen disorganized corneal stroma extracellular matrix), recapitulating some patients’ features. Our data support the notion that CPAMD8 loss-of-function underlies a spectrum of recessive CG-ASD phenotypes associated with extracellular matrix disorganization and provide new insights into the normal and disease roles of this gene

Adelante / Endavant

Séptimo desafío por la erradicación de la violencia contra las mujeres del Institut Universitari d’Estudis Feministes i de Gènere "Purificación Escribano" de la Universitat Jaume

Ahora / Ara

La cinquena edició del microrelatari per l’eradicació de la violència contra les dones de l’Institut Universitari d’Estudis Feministes i de Gènere «Purificación Escribano» de la Universitat Jaume I vol ser una declaració d’esperança. Aquest és el moment en el qual les dones (i els homes) hem de fer un pas endavant i eliminar la violència sistèmica contra les dones. Ara és el moment de denunciar el masclisme i els micromasclismes començant a construir una societat més igualitària. Cadascun dels relats del llibre és una denúncia i una declaració que ens encamina cap a un món millor

Taking care of our cultural heritage to preserve our history

Las piezas de interés cultural y artístico, nos llevan a comprender formas de vida que documentan siglos de experiencias compartidas con otros tiempos y espacios dignas de análisis para conocer el desarrollo del humano, desde las premisas que nos ofrece la Historia del Arte. El arte exige la necesidad de documentación, mantenimiento, divulgación y disfrute para la transmisión al futuro. Su preservación nos garantiza el buen estado y es el restaurador-conservador el profesional al servicio de la sociedad para su defensa y protección.Pieces of cultural and artistic interest, lead us to understand ways of life that document centuries of shared experiences with other times and spaces worthy of analysis in order to know the development of the human being, from the premises offered by the History of Art. Art entails the need of documentation, maintenance, divulgation and enjoyment for its transmission to the future. Its preservation guarantees a good condition for it and the restorer-conservator is the professional at the service of society for its defence and protection