Implementación en el H.C.U. Lozano Blesa de una técnica de rutina para la verificación de la constancia de dosis en aplicadores Leipzig usando una cámara pozo

En este trabajo se implementa una técnica de rutina para realizar la verificación posicional clínica que permita garantizar la constancia de dosis en los tratamientos de braquiterapia superficial con aplicadores Leipzig tipo V en el Hospital Clínico Universitario Lozano Blesa. Se obtienen los valores de referencia y sus tolerancias con los que comparar las medidas de las verificaciones rutinarias. Se caracterizan la isotropía, repetibilidad, reproducibilidad y sensibilidad de la técnica implementada con el inserto plástico diseñado y con la plantilla confeccionada como alternativa más accesible al inserto.<br /

Efecto de la gestión forestal en la cantidad de carbono del suelo mineral en una masa de Pinus pinaster Ait.

El conocimiento del impacto de la gestión forestal sobre los diversos compartimentos de carbono existentes en una masa forestal es prioritario para la sostenibilidad del aprovechamiento y gestión de los sistemas forestales. Con la aplicación de tratamientos selvícolas hay una serie de transformaciones en la masa como la reducción de biomasa en pie, la modificación de la cantidad de residuos o la disminución de la incorporación de hojarasca, la alteración del microclima del suelo por mayor presencia de luz y su influencia en las condiciones de humedad y temperatura. Este cambio en las condiciones modifica el contenido de carbono en el suelo. En este trabajo se ha estudiado la influencia que tiene la gestión forestal en las cantidades de carbono y nitrógeno presentes en los 30 primeros cm del suelo mineral más la hojarasca y humus de una masa de Pinus pinaster Ait., a partir de la comparación entre los cantidades de carbono bajo tres intensidades de claras. A partir de los resultados obtenidos no se han encontrado diferencias significativas entre los tratamientos, tanto en la cantidad de carbono y nitrógeno almacenado en la capa orgánica como en la capa mineral del suelo, por lo cual la realización de claras fuertes no modifica sustancialmente las cantidades de carbono acumuladas

Customizing the learning of mathematics with the flipped learning model

En este trabajo se plantea un entorno de aprendizaje autodirigido basado en el modelo pedagógico Flipped learning y apoyado en la tecnología, orientado a una personalización de la enseñanza de las matemáticas. Se pretende determinar si la experiencia realizada incide en el rendimiento académico, la satisfacción del alumnado, las emociones experimentadas y si se existen diferencias en función del género. Se ha utilizado una metodología cuantitativa con un diseño preexperimental pretest y postest. En la experiencia han participado 62 estudiantes que cursan la asignatura de Matemáticas orientadas a las enseñanzas académicas de 3º y 4º de Educación Secundaria Obligatoria. Los resultados muestran una mejora en el rendimiento académico, y un nivel de satisfacción elevado con la experiencia de aprendizaje. El modelo propuesto se ha adaptado a la diversidad del aula y superado las diferencias entre hombres y mujeres en cuanto a actitud y emociones con respecto a las matemáticas.This work outlines a self-directed learning environment which is based on the Flipped learning pedagogical model and supported by technology, aimed at personalising the teaching of mathematics. The target of this study is to determine how this tested-model impacts the academic performance, satisfaction levels and the emotional progress on the students; these are also reviewed based on gender. A quantitative methodology, based on a pre-experimental design that involves both, a pre-test and a post-test, has been used. The experience involved 62 students taking the subject of Mathematics oriented to the academic teaching of 3rd and 4th year of Compulsory Secondary Education. The collected data reflects an improvement on academic performance and high levels of satisfaction from the students. The proposed model has proved adaptable towards the student’ diversity and overcame the potential differences between men and women regarding their attitude and emotions toward the subject of Mathematics

Procalcitonin is not sufficiently reliable to be the sole marker of neonatal sepsis of nosocomial origin

BACKGROUND: It has recently been suggested that serum procalcitonin (PCT) is of value in the diagnosis of neonatal sepsis, with varying results. The aim of this prospective multicenter study was to assess the usefulness of PCT as a marker of neonatal sepsis of nosocomial origin. METHODS: One hundred infants aged between 4 and 28 days of life admitted to the Neonatology Services of 13 acute-care teaching hospitals in Spain over 1-year with clinical suspicion of neonatal sepsis of nosocomial origin were included in the study. Serum PCT concentrations were determined by a specific immunoluminometric assay. The reliability of PCT for the diagnosis of nosocomial neonatal sepsis at the time of suspicion of infection and at 12–24 h and 36–48 h after the onset of symptoms was calculated by receiver-operating characteristics (ROC) curves. The Youden's index (sensitivity + specificity - 1) was used for determination of optimal cutoff values of the diagnostic tests in the different postnatal periods. Sensitivity, specificity, and the likelihood ratio of a positive and negative result with the 95% confidence interval (CI) were calculated. RESULTS: The diagnosis of nosocomial sepsis was confirmed in 61 neonates. Serum PCT concentrations were significantly higher at initial suspicion and at 12–24 h and 36–48 h after the onset of symptoms in neonates with confirmed sepsis than in neonates with clinically suspected but not confirmed sepsis. Optimal PCT thresholds according to ROC curves were 0.59 ng/mL at the time of suspicion of sepsis (sensitivity 81.4%, specificity 80.6%); 1.34 ng/mL within 12–24 h of birth (sensitivity 73.7%, specificity 80.6%), and 0.69 ng/mL within 36–48 h of birth (sensitivity 86.5%, specificity 72.7%). CONCLUSION: Serum PCT concentrations showed a moderate diagnostic reliability for the detection of nosocomial neonatal sepsis from the time of suspicion of infection. PCT is not sufficiently reliable to be the sole marker of sepsis, but would be useful as part of a full sepsis evaluation

Global and Regional Deep Learning Models for Multiple Sclerosis Stratification From MRI

Altres ajuts: acords transformatius de la UABBackground: The combination of anatomical MRI and deep learning-based methods such as convolutional neural networks (CNNs) is a promising strategy to build predictive models of multiple sclerosis (MS) prognosis. However, studies assessing the effect of different input strategies on model's performance are lacking. Purpose: To compare whole-brain input sampling strategies and regional/specific-tissue strategies, which focus on a priori known relevant areas for disability accrual, to stratify MS patients based on their disability level. Study Type: Retrospective. Subjects: Three hundred nineteen MS patients (382 brain MRI scans) with clinical assessment of disability level performed within the following 6 months (~70% training/~15% validation/~15% inference in-house dataset) and 440 MS patients from multiple centers (independent external validation cohort). Field Strength/Sequence: Single vendor 1.5 T or 3.0 T. Magnetization-Prepared Rapid Gradient-Echo and Fluid-Attenuated Inversion Recovery sequences. Assessment: A 7-fold patient cross validation strategy was used to train a 3D-CNN to classify patients into two groups, Expanded Disability Status Scale score (EDSS) ≥ 3.0 or EDSS < 3.0. Two strategies were investigated: 1) a global approach, taking the whole brain volume as input and 2) regional approaches using five different regions-of-interest: white matter, gray matter, subcortical gray matter, ventricles, and brainstem structures. The performance of the models was assessed in the in-house and the independent external cohorts. Statistical Tests: Balanced accuracy, sensitivity, specificity, area under receiver operating characteristic (ROC) curve (AUC). Results: With the in-house dataset, the gray matter regional model showed the highest stratification accuracy (81%), followed by the global approach (79%). In the external dataset, without any further retraining, an accuracy of 72% was achieved for the white matter model and 71% for the global approach. Data Conclusion: The global approach offered the best trade-off between internal performance and external validation to stratify MS patients based on accumulated disability. Evidence Level: 4. Technical Efficacy: Stage 2

Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19

Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that plitidepsin distributes preferentially to lung over plasma, with similar potency against across several SARS-CoV-2 variants in preclinical studies. Simultaneously, in this randomized, parallel, open-label, proof-of-concept study (NCT04382066) conducted in 10 Spanish hospitals between May and November 2020, 46 adult hospitalized patients with confirmed SARS-CoV-2 infection received either 1.5 mg (n = 15), 2.0 mg (n = 16), or 2.5 mg (n = 15) plitidepsin once daily for 3 d. The primary objective was safety; viral load kinetics, mortality, need for increased respiratory support, and dose selection were secondary end points. One patient withdrew consent before starting procedures; 45 initiated treatment; one withdrew because of hypersensitivity. Two Grade 3 treatment-related adverse events were observed (hypersensitivity and diarrhea). Treatment-related adverse events affecting more than 5% of patients were nausea (42.2%), vomiting (15.6%), and diarrhea (6.7%). Mean viral load reductions from baseline were 1.35, 2.35, 3.25, and 3.85 log10 at days 4, 7, 15, and 31. Nonmechanical invasive ventilation was required in 8 of 44 evaluable patients (16.0%); six patients required intensive care support (13.6%), and three patients (6.7%) died (COVID-19-related). Plitidepsin has a favorable safety profile in patients with COVID-19.This work was supported by grants from the Government of Spain (PIE_INTRAMURAL_ LINEA 1 - 202020E079; PIE_INTRAMURAL_CSIC-202020E043). The research of CBIG consortium (constituted by IRTA-CReSA, BSC, & IrsiCaixa) is supported by Grifols pharmaceutical. We also acknowledge the crowdfunding initiative #Yomecorono (https://www.yomecorono.com). N Izquierdo-Useros has nonrestrictive funding from PharmaMar to study the antiviral effect of Plitidepsin. NJ Krogan was funded by grants from the National Institutes of Health (P50AI150476, U19AI135990, U19AI135972, R01AI143292, R01AI120694, and P01AI063302); by the Excellence in Research Award (ERA) from the Laboratory for Genomics Research (LGR), a collaboration between the University of California, San Francisco (UCSF), University of California, Berkley (UCB), and GlaxoSmithKline (GSK) (#133122P); by the Roddenberry Foundation, and gifts from QCRG philanthropic donors. This work was supported by the Defense Advanced Research Projects Agency (DARPA) under Cooperative Agreement #HR0011-19-2-0020. The views, opinions, and/or findings contained in this material are those of the authors and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. This research was partly funded by Center for Research for Influenza Pathogenesis and Transmission (CRIPT), a National Institute of Allergy and Infectious Diseases (NIAID) supported Center of Excellence for Influenza Research and Response (CEIRS, contract # 75N93021C00014), by DARPA grant HR0011-19-2-0020, by supplements to NIAID grants U19AI142733, U19AI135972, and DoD grant W81XWH-20-1-0270, and by the generous support of the JPB Foundation, the Open Philanthropy Project (research grant 2020-215611 (5384)), and anonymous donors to A García-Sastre. S Yildiz received funding from a Swiss National Foundation Early Postdoc Mobility fellowship (P2GEP3_184202).Peer reviewe

Neuroblastoma in Spain : Linking the national clinical database and epidemiological registries - A study by the Joint Action on Rare Cancers

Altres ajuts: Ministerio de Sanidad; Universitat de València; Sociedad Española de Oncología Pediátrica; Fundación de Oncología Infantil Enriqueta Villavecchia.Purpose: Linkage between clinical databases and population-based cancer registries may serve to evaluate European Reference Networks' (ERNs) activity, by monitoring the proportion of patients benefiting from these and their impact on survival at a population level. To test this, a study targeting neuroblastoma (Nb) was conducted in Spain by the European Joint Action on Rare Cancers. Material and methods: Subjects: Nb cases, incident 1999-2017, aged < 15 years. Linkage included: Spanish Neuroblastoma Clinical Database (NbCDB) (1217 cases); Spanish Registry of Childhood Tumours (RETI) (1514 cases); and 10 regional population-based registries (RPBCRs) which cover 33% of the childhood population (332 cases). Linkage was semiautomatic. We estimated completeness, incidence, contribution, deficit, and 5-year survival in the databases and specific subsets. Results: National completeness estimates for RETI and NbCDB were 91% and 72% respectively, using the Spanish RPBCRs on International Incidence of Childhood Cancer (https://iicc.iarc.fr/) as reference. RPBCRs' specific contribution was 1.6%. Linkage required manual crossover in 54% of the semiautomatic matches. Five-year survival was 74% (0-14 years) and 90% (0-18 months). Conclusions: All three databases were incomplete as regards Spain as a whole and should therefore be combined to achieve full childhood cancer registration. A unique personal patient identifier could facilitate such linkage. Most children have access to Nb clinical trials. Consolidated interconnections between the national registry and clinical registries (including ERNs and paediatric oncology clinical groups) should be established to evaluate outcomes

Conservation status of sea turtles in Spain (review of the period 2013-2018)

El presente documento revisa la situación y aporta nuevos datos para las tortugas marinas en España durante el periodo 2013- 2018. Se revisa el estado de conservación para el periodo 2013- 2018 en cada una de las demarcaciones marítimas españolas: Levante–Baleares y Estrecho–Alborán para el Mediterráneo, y Noratlántica, Sudatlántica y Macaronesia en aguas del océano Atlántico. Se incluyen análisis de tendencias, las presiones y amenazas que afectan a cada especie y bibliografía actualizada. Para Caretta caretta, se recopila la información de los nidos en las costas mediterráneas españolas desde 2013 hasta 2018 y los movimientos de juveniles nacidos en España, tras su liberación.This document reviews the situation and provides new data for sea turtles in Spain during the period 2013-2018. The conservation status for such period is reviewed in each of the Spanish maritime demarcations: Levante–Baleares and Estrecho–Alborán for the Mediterranean, and Noratlántica, Sudatlántica and Macaronesia in waters of the Atlantic Ocean. Analysis of trends, pressures and threats that affect each species and updated bibliography are included. For Caretta caretta, information is collected on nests on the Spanish Mediterranean coasts from 2013 to 2018 and the movements of juveniles born in Spain, after their release

Creación de recursos prácticos y digitales de meteorología y clima a través de Metolab

Depto. de Física de la Tierra y AstrofísicaFac. de Ciencias FísicasFALSEsubmitte

Estableciendo "puentes" entre la Universidad y el tejido social madrileño : cómo los estudiantes de la Asignatura Ciudad y Urbanismo pueden colaborar en la búsqueda de soluciones urbanísticas a históricas reclamaciones vecinales en el entorno de Puente de Vallecas

Publicación de los trabajos elaborados por los estudiantes del curso 2022/23 de la asignatura Ciudad y Urbanismo (35001304) de la Escuela Técnica Superior de Arquitectura de la Universidad Politécnica de Madrid en el marco de un proyecto de Aprendizaje-Servicio y reflexiones sobre el proceso tanto de los agentes sociales que formaron parte del mismo, como de los profesores que ha participado en la docencia