Impacto del tratamiento periodontal en el ratio rnakl/opg

La reabsorción ósea es uno de los procesos con mayor transcendencia en la periodontitis. El descubrimiento del eje RANKL/RANL/0PG (receptor activador de la osteoclastogénesis) supuso un avance en la comprensión del remodelado óseos fisiológico y patológico. Los recientes estudios realizados tanto a nivel histológico como a nivel del fluido crevicular, han comprobado el aumento del ratio RANKL/OPG en los pacientes con periodontitis.Nuevos conocimientos en ésta línea aportarán información sobre la patogenia y por tanto podrían ser utilizados en el diagnóstico y tratamiento periodontal. Objetivo: Determinar el efecto del tratamiento periodontal básico (raspado y alisado radicular, junto con instrucciones en higiene oral) sobre el ratio RANKL/OPG, en el fluido crevicular de pacientes con enfermedad periodontal activa. Material y métodos: El estudio se realizó en dientes unirradiculares de 25 individuos. 10 pacientes sanos periodontalmente (grupo control) y 15 pacientes con periodontitis crónica avanzada (grupo de estudio). Se realizaron registros clínicos y bioquímicos en ambos grupos. Las muestras de fluido crevicular de los pacientes con periodontitis, se tomaron en bolsas de más 6 mm, zona enferma (ZE), y en zonas sanas (ZS) (profundidad de sondaje ≤ 3mm) antes y después del tratamiento periodontal básico. El volumen del fluido crevicular se midió con el Periotron 8000 y se analizó mediante técnicas de inmunoensayo. Resultados: Para la valoración de los resultados se uso el test ANOVA con el método de Student-Newman-Keuls. La significancia se estableció en p < 0.05. Los resultados demuestran que los niveles de OPG son más elevados en el grupo control que en cualquier muestra del grupo test, lo que da a pensar que pueden haber factores genéticos que determinen estos niveles. Los niveles de RANKL se vieron elevados en las ZE comparadas con ZS de lo pacientes test y controles, lo que demuestra que la actividad osteoclástica está influenciada por los factores locales de inflamación. Conclusión: El tratamiento periodontal básico disminuye los niveles del ratio RANKL/OPG hasta niveles similares a los controles. También se demuestra que las ZE tienen niveles más elevados de RANKL a lo que además se le asocia unos niveles basales de OPG, lo cual favorece que haya un mayor proceso de destrucción ósea

Indicadores básicos del sistema universitario argentino

Production of INCASI Project H2020-MSCA-RISE-2015 GA 691004La educación superior en la Argentina comprende el acceso al sector universitario tanto de las carreras de pregrado, grado y de postgrado. En general, este sector ha experimentado un elevado ritmo de crecimiento. El objetivo del presente análisis es presentar indicadores básicos para realizar un seguimiento del sistema universitario. Este informe pretende dotar de información simple y estratégica mediante la construcción de indicadores y análisis estadísticos que permitan conocer la estructura y la evolución de la educación universitaria de pregrado, grado y posgrado en las instituciones de gestión pública y privada de Argentina. Se utiliza la información provista por la Secretaría de Políticas Universitarias (SPU) en sus informes anuales, y los datos recabados por el Censo Nacional de Población, Hogares y Viviendas (CNPHV) de Argentina de los años 2001 y 2010, los cuales permitieron construir una serie de indicadores que pretenden dar luz sobre la evolución del complejo sistema universitario. A su vez es la continuidad del Informe "Análisis del sistema universitario argentino. Una propuesta inicial de indicadores" realizado en 2017 (https://ddd.uab.cat/record/171528)

The 100 most cited articles in peri-implant diseases. A bibliometric study of the web of science

The purpose of the study was to analyze the 100 most-cited articles on peri-implantitis pathology in the Web of Science database. The articles were selected from all categories of the Web of Science, to consider all variations and synonyms of peri-impl

A controlled clinical study of periodontal health in anticoagulated patients : assessment of bleeding on probing

According to the Spanish Society of Cardiology, 700,000 patients receive oral anticoagulants, and in these cases bleeding on probing (BOP) could be altered. However, no studies have analyzed the periodontal status of these patients and the effects anticoagulants may have upon BOP. A study was made of the possible relationship between plaque index, probing depth, INR (International Normalized Ratio) and acenocoumarol dose versus the clinical signs of BOP in a sample of anticoagulated patients. Likewise, an analysis was made of oral hygiene habits and attitude towards bleeding in these patients. A controlled observational clinical study was made in La Ribera Hospital (Valencia, Spain) involving 44 anticoagulated patients treated with Sintrom® (acenocoumarol) and a homogeneous control group of 44 non-anticoagulated patients. A survey on oral hygiene habits and attitude towards bleeding was carried out, and the main periodontal parameters were recorded. Probing depth was the parameter with the strongest correlation to BOP (p<0.001), followed by the plaque index (p<0.002). In contrast, no relationship was observed between acenocoumarol dose or INR and BOP. Mean BOP was greater in the control group than in the anticoagulated group (p<0.001). Oral hygiene habits and attitude towards bleeding differed significantly between groups. We have found no explanation why BOP was greater in the control group. What seems clear is that in the presence of the same plaque index and probing depth, anticoagulated patients did not bleed more than non-anticoagulated patients. A lack of knowledge of health and oral hygiene habits was observed in these subjects

Bone resorption processes in patients wearing overdentures : a 6-years retrospective study

1. ? To measure the alveolar resorption processes that occur in patients wearing mandibular overdentures on 2 implants and fully-removable maxillary dentures, and to evaluate the same process on patients wearing fullyremovable dentures on both arches. 2.- To verify whether Kelly?s Combination Syndrome occurs in the group of patients wearing overdentures. Method and Material: Forty patients were evaluated, of which a ?cases? group was formed by 25 patients wearing mandibular overdentures on 2 lower jaw implants and fully-removable dentures on the opposite arch. The other 15 patients formed a control group that wore fully-removable dentures on both arches. Each one of the patients underwent orthopantograms from the moment the dentures were inserted until an average of 6 years later, which were assessed based on the Xie et al. method to estimate vertical bone loss. Once the data was collected, it was subjected to statistical analysis. Results: In terms of the maxillary midline, we observed a greater loss in patients wearing overdentures, which was statistically significant, as it registered 0.32 mm/year. Mandibular bone loss was 2.5 times less in patients in the cases group. The rest of the clinical criteria for Kelly?s Combination Syndrome were not observed. Conclusions: Kelly?s Combination Syndrome did not occur in the patients in the cases group. In spite of the greater bone loss on a premaxillary level in this group, the placing of the overdenture on the implants significantly reduced mandibular bone resorption

Stability behaviour of composite magnetorheological fluids by an induction method

Este artículo puede consultarse en la siguiente dirección de la editorial: http://jim.sagepub.com/content/early/2015/03/26/1045389X15577656.full.pdf+htmlIn this work we study the stability behaviour of composite magnetorheological (MR) fluids consisting of magnetic (iron) and non-magnetic (poly (methylmethacrylate), PMMA) particles dispersed in mineral oil. Because of the opacity of the suspensions, optical methods traditionally employed for evaluation of the gravitational settling in colloidal suspensions are not suitable for sedimentation follow-up in this case. For this reason, we use an alternative method based on the evaluation of the resonant frequency of the inductance of a thin coil surrounding the sample The movement of the coil along the height of the container at specified steps and time intervals allows obtaining information about the local volume fraction of particles inside the tube. The obtained successive profiles for the multi-component suspensions show a decrease of the iron particle settling and of the initial rate of settling as the PMMA volume fraction is increased. Finally, the increase of the PMMA concentration gives rise to an improvement of the rheological properties upon magnetic field application for a given concentration of iron. Both a strongrheological response and a good colloidal stability are essential for practical applications.Proyectos PE2012-FQM694 (Junta de Andalucía, Spain)y FIS2013-47666-C3-1-R (Ministerio de Economía y Competitividad, Spain). L. R.-A. agrradece a la Universidad de Granada su contrato puente (Plan Propio de Investigación, UGR)

Comparison of the clinical effects of white brand toothbrushes versus Vitis Suave®

Background: There has been an increase in the use of white label manual toothbrushes and a greater increase in inquiries for discomfort of the gingiva and mucosa. Material and Methods: A randomized, double-blind, cross-over clinical trial was made of four white brand toothbrushes versus a control brush (Vitis Suave®), with the recording of plaque index, bleeding upon probing, and gingival abrasions following utilization of the different brushes. Results: All the brushes except Deliplus® were equally effective in terms of plaque removal ( p <0.05). Vitis Suave® and Veckia® were the brushes associated to the greatest increase in minor abrasions ( p <0.01), while Veckia®, Carrefour® and Deluxe® significantly increased the number of medium intensity abrasions ( p <0.05). These brushes also increased the number of large abrasions, though statistical significance was not reached in this case. Conclusions: The white brand brushes proved effective in controlling bacterial plaque, but were associated to more intense soft tissue abrasio

Performance of the dentogingival junction with mta and biodentine on the treatment of invasive cervical resorptions. A literature review and case report

Invasive cervical resorption (ICR) is an uncommon phenomenon (0.1%), however, it represents a challenge to the structural and functional integrity of the dentogingival junction, as well as a risk for the survival of the affected tooth. They are character

Epigenetics and periodontics : a systematic review

Despite decades of research, our knowledge of several important aspects of periodontal pathogenesis remains incomplete. Epigenetics allows to perform dynamic analysis of different variations in gene expression, providing this great advantage to the static measurement provided by genetic markers. The aim of this systematic review is to analyze the possible relationships between different epigenetic mechanisms and periodontal diseases, and to assess their potential use as biomarkers of periodontitis. A systematic search was conducted in six databases using MeSH and non-MeSH terms. The review fulfilled PRISMA criteria (Preferred Reporting Items for Systematic reviews and Meta-analysis). 36 studies met the inclusion criteria. Due to the heterogeneity of the articles, it was not possible to conduct quantitative analysis. Regarding qualitative synthesis, however, it was found that epigenetic mechanisms may be used as biological markers of periodontal disease, as their dynamism and molecular stability makes them a valuable diagnostic tool. Epigenetic markers alter gene expression, producing either silencing or over-expression of molecular transcription that respond to the demands of the cellular surroundings. Gingival crevicular fluid collection is a non-invasive and simple procedure, which makes it an ideal diagnostic medium for detection of both oral and systemic issues. Although further research is needed, this seems to be a promising field of research in the years to come

miR-1226 detection in GCF as potential biomarker of chronic periodontitis: a pilot study

The study and identification of new biomarkers for periodontal disease, such as microRNAs (miRNAs), may give us more information about the location and severity of the disease and will serve as a basis for treatment planning and disease-monitoring. miRNAs are a group of small RNAs which are involved in gene regulation by binding to their messenger RNA target (mRNA). In this pilot study, the procedure for purifying miRNAs from gingival crevicular fluid (GCF) was, for the first time, described. In addition, the concentration of miRNAs in GCF was analyzed and compared between patients with moderate or severe chronic periodontitis (CP) and healthy controls. GCF samples were collected from single-rooted teeth of patients with moderate or severe CP (n=9) and of healthy individuals (n=9). miRNAs were isolated from GCF using miRNeasy Serum/Plasma kit (Qiagen, CA. USA). Reverse transcription polymerase chain reaction (qRT-PCR) was used to determine the expression of a series of miRNAs candidates that are related to bone metabolism. The significance of differences in miRNA levels between both groups was determined using Mann-Whitney U test. The results from this pilot study indicate that miRNAs can be isolated from GCF. Six different miRNAs were analyzed (miR-671, miR-122, miR-1306, miR-27a, miR-223, miR-1226), but only miR-1226 showed statically significant differences between the CP group and healthy controls (p<0.05). This miRNA was downregulated in patients with CP. Within the limitations of the present study, it may be concluded that miR-1226 can be a promising biomarker for periodontal disease, adding relevant information to common clinical parameters used for diagnosis and prognosis of periodontitis