análisis de estabilidad de tensión en el sistema de transmisión regional (STR)

El presente trabajo recopila información relacionada con un estudio de estabilidad de voltaje que fue realizado al sistema eléctrico de la ciudad de Pereira para efectos académicos, el análisis se realizó a por medio del simulador Neplan haciendo uso del módulo de estabilidad de voltaje. Las metodologías utilizadas jugaron un papel importante a la hora de presentarse diversos mecanismos para interpretar los elementos y nodos que son más susceptibles al colapso de voltaje en el sistema. Metodologías como Análisis Modal, Análisis de Sensibilidad y la interpretación de las curvas V-Q y P-V en las cuales se puede observar los diversos márgenes de potencia reactiva y activa. El estudio de estabilidad de voltaje se hizo para tres casos de prueba: Cargabilidad máxima, Demanda máxima del sistema y demanda mínima del sistema; al finalizar el análisis se identificaron los nodos críticos y las zonas de mayor vulnerabilidad respecto a la estabilidad de voltaje del STR

Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders

Increasing evidence in the last years indicates that the vast amount of regulatory information contained in mammalian genomes is organized in precise 3D chromatin structures. However, the impact of this spatial chromatin organization on gene expression and its degree of evolutionary conservation is still poorly understood. The Six homeobox genes are essential developmental regulators organized in gene clusters conserved during evolution. Here, we reveal that the Six clusters share a deeply evolutionarily conserved 3D chromatin organization that predates the Cambrian explosion. This chromatin architecture generates two largely independent regulatory landscapes (RLs) contained in two adjacent topological associating domains (TADs). By disrupting the conserved TAD border in one of the zebrafish Six clusters, we demonstrate that this border is critical for preventing competition between promoters and enhancers located in separated RLs, thereby generating different expression patterns in genes located in close genomic proximity. Moreover, evolutionary comparison of Six-associated TAD borders reveals the presence of CCCTC-binding factor (CTCF) sites with diverging orientations in all studied deuterostomes. Genome-wide examination of mammalian HiC data reveals that this conserved CTCF configuration is a general signature of TAD borders, underscoring that common organizational principles underlie TAD compartmentalization in deuterostome evolution

Mucosal Immune Defence Gene Polymorphisms as Relevant Players in the Pathogenesis of IgA Vasculitis?

ITGAM–ITGAX (rs11150612, rs11574637), VAV3 rs17019602, CARD9 rs4077515, DEFA (rs2738048, rs10086568), and HORMAD2 rs2412971 are mucosal immune defence polymorphisms, that have an impact on IgA production, described as risk loci for IgA nephropathy (IgAN). Since IgAN and Immunoglobulin-A vasculitis (IgAV) share molecular mechanisms, with the aberrant deposit of IgA1 being the main pathophysiologic feature of both entities, we assessed the potential influence of the seven abovementioned polymorphisms on IgAV pathogenesis. These seven variants were genotyped in 381 Caucasian IgAV patients and 997 matched healthy controls. No statistically significant differences were observed in the genotype and allele frequencies of these seven polymorphisms when the whole cohort of IgAV patients and those with nephritis were compared to controls. Similar genotype and allele frequencies of all polymorphisms were disclosed when IgAV patients were stratified according to the age at disease onset or the presence/absence of gastrointestinal or renal manifestations. Likewise, no ITGAM–ITGAX and DEFA haplotype differences were observed when the whole cohort of IgAV patients, along with those with nephritis and controls, as well as IgAV patients, stratified according to the abovementioned clinical characteristics, were compared. Our results suggest that mucosal immune defence polymorphisms do not represent novel genetic risk factors for IgAV pathogenesis

Geoquímica y mineralogía de la mina La Pava, Muzo-Quípama: implicaciones en la exploración de esmeraldas en Colombia

La mina La Pava es parte del distrito esmeraldífero de Muzo-Quípama, Colombia; allí la presencia de esmeraldas se asocia con pelitas de la Formación Muzo. La mineralización es controlada espacialmente por el Anticlinal de La Pava —un pliegue por propagación de falla— y se restringe a zonas que han experimentado intensa alteración hidrotermal (albitización y carbonatización). Los principales rasgos observados en las venas productivas son las asociaciones paragenéticas de albita-xenotimo-fluorapatito y calcita-dolomita, los cuales van acompañados de anomalías geoquímicas positivas de Y, P, Mn y Mg. Adicionalmente, se presentan anomalías negativas de Li-Cs-Be-Ti que representan indicadores consistentes de la lixiviación de estos elementos en las rocas y su posterior concentración en venas y brechas hidrotermales. Se concluye que en La Pava existen parámetros estructurales, estratigráficos, mineralógicos y geoquímicos que permiten identificar bloques potenciales para hospedar mineralizaciones de esmeraldas.The La Pava mine is located in the Muzo-Quípama district, Colombia; there, the emeralds are hosted by pelites from the Muzo Formation. The mineralization is spatially associated with the La Pava Anticline —a faultpropagation fold— and restricted to strongly altered zones (albitized and carbonatized). The main features displayed by the fertile veins are the mineral assemblages that include albite-xenotime-fluorapatite and calcitedolomite, and their corresponding positive geochemical anomalies: Y, P, Mn, and Mg. Moreover, there is a consistent negative anomaly of Li-Cs-Be-Ti, which means these elements were effectively leached from the host rocks and subsequently concentrated as infill products in the hydrothermal veins. As a concluding remark, we identified a sort of parameters, regarding structures, stratigraphy, mineralogy, and geochemistry, that can be useful in defining exploration targets for emerald deposits

Mucosal immune defence polymorphisms: relevant players in IgA vasculitis?

Congresos y Comunicaciones: Comunicación, Congreso - póster

Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis

Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV.Acknowledgements: We are indebted to the patients and healthy controls for their essential collaboration to this study. We also thank the National DNA Bank Repository (Salamanca) for supplying part of the control samples. This study was supported by European Union FEDER funds and `Fondo de Investigaciones Sanitarias´ (Grant PI18/00042) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). DP-P is a recipient of a Río Hortega programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) (Grant Number CM20/00006). SR-M is supported by funds of the RETICS Program (RD16/0012/0009) (ISCIII, cofunded by the European Regional Development Fund (ERDF)). VP-C is supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). BA-M is a recipient of a `López Albo´ Post-Residency Programme funded by Servicio Cántabro de Salud. LL-G is supported by funds from IDIVAL (INNVAL20/06). OG is staff personnel of Xunta de Galicia (Servizo Galego de Saude (SERGAS)) through a research-staff stabilization contract (ISCIII/SERGAS) and his work is funded by ISCIII and the European Union FEDER fund (Grant Numbers RD16/0012/0014 (RIER) and PI17/00409). He is beneficiary of project funds from the Research Executive Agency (REA) of the European Union in the framework of MSCA-RISE Action of the H2020 Programme, project 734899—Olive-Net. RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by ESF (`Investing in your future´) (Grant Number CP16/00033)

Saber pedagógico en innovación, TIC y gamificación

168 p. Libro electronico*) Haciendo visibles las habilidades de pensamiento científico en primera infancia 15 *) Enseñanza de la física de manera no convencional a través de clubes de ciencia. Semillero de investigación escolar. Club de Ciencia y Tecnología: Bicienergía 34. *) Uso del programa GeoGebra con estudiantes de undécimo grado del colegio Llano Oriental 52. *) Voces que Emocionan. Un espacio de participación y construcción colectiva que permite la articulación entre la educación media y la educación inicial 60. *) Articulación Educativa. Las Voces que Emocionan unen generaciones desde la creatividad emocional 75. *) Mediaciones edu-comunicativas en la formación de jóvenes como comunicadores sentipensantes 88. *) FilosoTICS. Filosofía e innovación en tecnología para el siglo XXI 104. *) Arqueoastronomía y la construcción de las nociones de simultaneidad y sucesión histórica en niños entre 10 y 15 años 120 *)Proyectiva: competencias, habilidades, capacidades, intereses y talentos para el siglo XXI 134. *) Plataformas virtuales de aprendizaje en la educación (Mediación TIC en la Educación Física) 154.Primera edicionPublicación resultado del programa Maestros y Maestras que Inspiran, una apuesta para la educación del siglo XXI, adelantada desde la línea Innovación, TIC y Gamificación, por los autores de este texto, con el acompañamiento del siguiente equipo: Maestro mentor Jaime Álvarez López Asistente de línea Andrea del Pilar Lara Maldonado. Las opiniones son responsabilidad de los autores

IgA Vasculitis: Influence of CD40, BLK and BANK1 Gene Polymorphisms

CD40, BLK and BANK1 genes involved in the development and signaling of B-cells are identified as susceptibility loci for numerous inflammatory diseases. Accordingly, we assessed the potential influence of CD40, BLK and BANK1 on the pathogenesis of immunoglobulin-A vasculitis (IgAV), predominantly a B-lymphocyte inflammatory condition. Three genetic variants within CD40 (rs1883832, rs1535045, rs4813003) and BLK (rs2254546, rs2736340, rs2618476) as well as two BANK1 polymorphisms (rs10516487, rs3733197), previously associated with inflammatory diseases, were genotyped in 382 Caucasian patients with IgAV and 955 sex- and ethnically matched healthy controls. No statistically significant differences were observed in the genotype and allele frequencies of CD40, BLK and BANK1 when IgAV patients and healthy controls were compared. Similar results were found when CD40, BLK and BANK1 genotypes or alleles frequencies were compared between patients with IgAV stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations. Moreover, no CD40, BLK and BANK1 haplotype differences were disclosed between patients with IgAV and healthy controls and between patients with IgAV stratified according to the clinical characteristics mentioned above. Our findings indicate that CD40, BLK and BANK1 do not contribute to the genetic background of IgAV

IgAV and IgAN: a single entity regarding CD40, BLK and BANK1 polymorphisms.

Congresos y conferencias: Comunicación de congreso - oral