The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study

Polymorphisms in the fatty acid desaturase (FADS) genes influence the arachidonic (AA) and docosahexaenoic (DHA) acid concentrations (crucial in early life). Infants with specific genotypes may require different amounts of these fatty acids (FAs) to maintain an adequate status. The aim of this study was to determine the effect of an infant formula supplemented with AA and DHA on FAs of infants with different FADS genotypes. In total, 176 infants from the COGNIS study were randomly allocated to the Standard Formula (SF; n = 61) or the Experimental Formula (EF; n = 70) group, the latter supplemented with AA and DHA. Breastfed infants were added as a reference group (BF; n = 45). FAs and FADS polymorphisms were analyzed from cheek cells collected at 3 months of age. FADS minor allele carriership in formula fed infants, especially those supplemented, was associated with a declined desaturase activity and lower AA and DHA levels. Breastfed infants were not affected, possibly to the high content of AA and DHA in breast milk. The supplementation increased AA and DHA levels, but mostly in major allele carriers. In conclusion, infant FADS genotype could contribute to narrow the gap of AA and DHA concentrations between breastfed and formula fed infants.This research was funded by ORDESA Laboratories, S.L., Spanish Ministry of Economy, Industry and Competitiveness, NEOBEFOOD Project (2010–2013) and SMARTFOODS Project (2014–2018)—CIEN Strategy (Ministry of Innovation and Science-CDTI) through 2 different contracts established between Ordesa Laboratories and the University of Granada General Foundation (ref. nº3349 and nº4003, respectively) and between Ordesa Laboratories and the Bosch Gimpera Foundation/University of Barcelona (ref. n 306811 and 308516). The project was partially funded by EU Project DynaHEALTH (HORIZON 2020-GA No.633595)

Residual biomass calculation from individual tree architecture using terrestrial laser scanner and ground-level measurements

Large quantity of residual biomass with possible energy and industrial end can be obtained from management operations of urban forests. The profitability of exploiting this resource is conditioned by the amount of existing biomass within urban community ecosystems. Prior research pointed out that residual biomass from Platanus hispanica and other tree species can be calculated from dendrometric parameters. In this study, two approaches have been analyzed: First, applicability of TLS was tested for residual biomass calculation from crown volume. In addition, traditional models for residual biomass prediction were developed from dendrometric parameters (tree height, crown diameter, and diameter at breast height). Next, a comparison between parameters obtained with both methodologies (standard methodologies vs TLS) was carried out. The results indicate a strong relationship (R2 = 0.906) between crown diameters and between total tree heights (R2 = 0.868). The crown volumes extracted from the TLS point cloud were calculated by 4 different methods: convex hull; convex hull by slices of 5 cm height in the XY plane; triangulation by XY flat sections, and voxel modeling. The highest accuracy was found when the voxel method was used for pruned biomass prediction (R2 = 0.731). The results revealed the potential of TLS data to determine dendrometric parameters and biomass yielded from pruning quitar of urban forestsFernández-Sarría, A.; Velázquez Martí, B.; Sajdak, M.; Martinez, L.; Estornell Cremades, J. (2013). Residual biomass calculation from individual tree architecture using terrestrial laser scanner and ground-level measurements. Computers and Electronics in Agriculture. 93:90-97. doi:10.1016/j.compag.2013.01.012S90979

Estimation of wood volume and height of olive tree plantations using airborne discrete-return LiDAR data

The aim of this study is to analyze methodologies based on airborne LiDAR (light detection and ranging) technology of low pulse density points (0.5m(-2)) for height and volume quantification of olive trees in Viver (Spain). A total of 29 circular plots, each with a radius of 20m, were sampled and their volumes and heights were obtained by dendrometric methods. For these estimations, several statistics derived from LiDAR data were calculated in each plot. Regression models were used to predict volume and height. The results showed good performance for estimating volume (R-2=0.70) and total height (R-2=0.67).The authors appreciate the financial support provided by the Spanish Ministerio de Ciencia e Innovacion (Ministry for Science & Innovation) within the framework of the project AGL2010-15334 and by the Vice-Rectorate for Research of the Universitat Politecnica de Valencia [Grant PAID-06-12-3297; SP20120534].Estornell Cremades, J.; Velázquez Martí, B.; López Cortés, I.; Salazar Hernández, DM.; Fernández-Sarría, A. (2014). Estimation of wood volume and height of olive tree plantations using airborne discrete-return LiDAR data. GIScience and Remote Sensing. 51(1):17-29. https://doi.org/10.1080/15481603.2014.883209S1729511Estornell, J., Ruiz, L. A., Velázquez-Martí, B., & Fernández-Sarría, A. (2011). Estimation of shrub biomass by airborne LiDAR data in small forest stands. Forest Ecology and Management, 262(9), 1697-1703. doi:10.1016/j.foreco.2011.07.026García, M., Riaño, D., Chuvieco, E., & Danson, F. M. (2010). Estimating biomass carbon stocks for a Mediterranean forest in central Spain using LiDAR height and intensity data. Remote Sensing of Environment, 114(4), 816-830. doi:10.1016/j.rse.2009.11.021Hyyppa, J., Kelle, O., Lehikoinen, M., & Inkinen, M. (2001). A segmentation-based method to retrieve stem volume estimates from 3-D tree height models produced by laser scanners. IEEE Transactions on Geoscience and Remote Sensing, 39(5), 969-975. doi:10.1109/36.921414Kim, Y., Yang, Z., Cohen, W. B., Pflugmacher, D., Lauver, C. L., & Vankat, J. L. (2009). Distinguishing between live and dead standing tree biomass on the North Rim of Grand Canyon National Park, USA using small-footprint lidar data. Remote Sensing of Environment, 113(11), 2499-2510. doi:10.1016/j.rse.2009.07.010Moorthy, I., Miller, J. R., Berni, J. A. J., Zarco-Tejada, P., Hu, B., & Chen, J. (2011). Field characterization of olive (Olea europaea L.) tree crown architecture using terrestrial laser scanning data. Agricultural and Forest Meteorology, 151(2), 204-214. doi:10.1016/j.agrformet.2010.10.005Næsset, E. (2004). Accuracy of forest inventory using airborne laser scanning: evaluating the first nordic full-scale operational project. Scandinavian Journal of Forest Research, 19(6), 554-557. doi:10.1080/02827580410019544Popescu, S. C. (2007). Estimating biomass of individual pine trees using airborne lidar. Biomass and Bioenergy, 31(9), 646-655. doi:10.1016/j.biombioe.2007.06.022Popescu, S. C., Wynne, R. H., & Nelson, R. F. (2002). Estimating plot-level tree heights with lidar: local filtering with a canopy-height based variable window size. Computers and Electronics in Agriculture, 37(1-3), 71-95. doi:10.1016/s0168-1699(02)00121-7Velázquez-Martí, B., Estornell, J., López-Cortés, I., & Martí-Gavilá, J. (2012). Calculation of biomass volume of citrus trees from an adapted dendrometry. Biosystems Engineering, 112(4), 285-292. doi:10.1016/j.biosystemseng.2012.04.011Velázquez-Martí, B., Fernández-González, E., Estornell, J., & Ruiz, L. A. (2010). Dendrometric and dasometric analysis of the bushy biomass in Mediterranean forests. Forest Ecology and Management, 259(5), 875-882. doi:10.1016/j.foreco.2009.11.027Velázquez-Martí, B., Fernández-González, E., López-Cortés, I., & Salazar-Hernández, D. M. (2011). Quantification of the residual biomass obtained from pruning of trees in Mediterranean olive groves. Biomass and Bioenergy, 35(7), 3208-3217. doi:10.1016/j.biombioe.2011.04.042Yu, X., Hyyppä, J., Kaartinen, H., & Maltamo, M. (2004). Automatic detection of harvested trees and determination of forest growth using airborne laser scanning. Remote Sensing of Environment, 90(4), 451-462. doi:10.1016/j.rse.2004.02.00

Malaria vector species in Colombia: a review

Here we present a comprehensive review of the literature on the vectorial importance of the major Anopheles malaria vectors in Colombia. We provide basic information on the geographical distribution, altitudinal range, immature habitats, adult behaviour, feeding preferences and anthropophily, endophily and infectivity rates. We additionally review information on the life cycle, longevity and population fluctuation of Colombian Anopheles species. Emphasis was placed on the primary vectors that have been epidemiologically incriminated in malaria transmission: Anopheles darlingi, Anopheles albimanus and Anopheles nuneztovari. The role of a selection of local, regional or secondary vectors (e.g., Anopheles pseudopunctipennis and Anopheles neivai) is also discussed. We highlight the importance of combining biological, morphological and molecular data for the correct taxonomical determination of a given species, particularly for members of the species complexes. We likewise emphasise the importance of studying the bionomics of primary and secondary vectors along with an examination of the local conditions affecting the transmission of malaria. The presence and spread of the major vectors and the emergence of secondary species capable of transmitting human Plasmodia are of great interest. When selecting control measures, the anopheline diversity in the region must be considered. Variation in macroclimate conditions over a species' geographical range must be well understood and targeted to plan effective control measures based on the population dynamics of the local Anopheles species

Current understanding of the hypothalamic ghrelin pathways inducing appetite and adiposity.

Ghrelin is a multifaceted regulator of metabolism. Ghrelin regulates energy balance in the short term via induction of appetite and in the long term via increased body weight and adiposity. Recently, several central pathways modulating the metabolic actions of ghrelin were unmasked, and it was shown to act through different hypothalamic nuclei to induce feeding. Ghrelin also modulates glucose homeostasis, but the central mechanisms responsible for this action have not been studied in detail. Although ghrelin also acts through extrahypothalamic areas to promote feeding, this review specifically dissects hypothalamic control of ghrelin's orexigenic and adipogenic actions and presents current understanding of the intracellular ghrelin orexigenic pathways, including their dependence on other relevant systems implicated in energy balance. The lack of ghrelin in adulthood has no effect on feeding or body weight. Ghrelin- or ghrelin receptor-deficient mice fed a high-fat diet after weaning and neuronal deletion of ghrelin receptor are diet-induced resistant. Ghrelin inhibition before weaning caused increased adiposity and feeding.Energy sensors controlling neuronal function and plasticity are located in the hypothalamus and ghrelin acts through these energy sensors to modulate feeding.The orexigenic but not the adipogenic action of ghrelin is impaired in obese animals.Mutations in the ghrelin receptor that prevented its binding to beta-arrestin did not influence ghrelin orexigenic action but increased its effects on adiposity and insulin resistance.Ghrelin's actions on energy and glucose homeostasis are of clinical relevance: ghrelin agonists show beneficial effects in patients with cancer cachexia; and an agonist of des-acyl ghrelin improves insulin sensitivity in humans

An updated view on human neonatal thermogenesis.

The maintenance and regulation of body temperature in neonates is critical for survival. However, the mechanisms by which human neonates achieve body temperature control are unclear. Current evidence has demonstrated that infrared thermography is a suitable non-invasive technique that can be safely applied to human babies to investigate brown adipose tissue thermogenesis

Erbium ring fiber laser cavity based on tip modal interferometer and its tunable multi-wavelength response for refractive index and temperature

A tunable multi-wavelength fiber laser is proposed and demonstrated based on two main elements: an erbium-doped fiber ring cavity and compact intermodal fiber structure. The modal fiber interferometer is fabricated using the cost-effective arc splice technique between conventional single-mode fiber and microfiber. This optical fiber structure acts as a wavelength filter, operated in reflection mode. When the refractive index and temperature variations are applied over the fiber filter, the ring laser cavity provides several quad-wavelength laser spectra. The multi-wavelength spectra are tuned into the C-band with a resolution of 0.05 nm. In addition, the spectra are symmetric with minimal power difference between the lasing modes involved, and the average of the side mode suppression ratio is close to 37 dB. This laser offers low-cost implementation, low wavelength drift, and high power stability, as well as an effect of easy controllability regarding tuned multi-wavelengt

Uroguanylin action in the brain reduces weight gain in obese mice via different efferent autonomic pathways

The gut-brain axis is of great importance in the control of energy homeostasis. The identification of uroguanylin (UGN), an intestinal released peptide regulated by nutritional status and with anorectic actions, as the endogenous ligand for guanylyl cyclase 2C (GUCY2C) receptor, has revealed a new system in the regulation of energy balance. We show that chronic central infusion of uroguanylin (UGN) reduces weight gain and adiposity in diet-induced obese mice. These effects were independent of food intake and involved specific efferent autonomic pathways. On one hand, brain UGN induces brown adipose tissue thermogenesis as well as browning and lipid mobilization in white adipose tissue through stimulation of the sympathetic nervous system. On the other hand, brain UGN augments fecal output through the vagus nerve. These findings are of relevance as they suggest that the beneficial metabolic actions of UGN through the sympathetic nervous system do not involve non-desirable gastrointestinal adverse effects, such as diarrhea. The present work provides mechanistic insights on how UGN influences energy homeostasis and suggests that UGN action in the brain represents a feasible pharmacological target in the treatment of obesity