Estudio de la generación y propagación de ondas de Rossby a pequeña escala

El propósito de este trabajo es generar ondas de Rossby en el laboratorio a pequeña escala y estudiar su mecanismo de formación. Por tanto se pretende observar la teoría descrita por Rossby a través de la generación de ondas en el experimento. Estas ondas son importantes para caracterizar la distribución de la temperatura en el océano y la atmósfera. Para ello se estudiaran diferentes casos para comprobar dicha teoría, modificando el plano de inclinación o la velocidad de rotación. La parte numérica está basada en fórmulas de diferentes experimentos y estudios de dichas ondas en las que se tiene en cuenta la esfericidad de la Tierra, la componente de Coriolis, el potencial de vorticidad, además de otros parámetros como la latitud (plano ß) o la profundidad del fluido. La parte experimental se realiza en una tabla giratoria en la cual se sitúa un tanque de PVC con agua en la que se simulará la rotación de la Tierra y la variación latitudinal. Las ondas serán observadas gracias a la elaboración de cubos de hielo con colorante que permitirán la visualización de dichas ondas.The aim of this research is to generate Rossby waves in the laboratory to small scale and to study the mechanism of them formation. Therefore, it pretends to observe the theory described by Rossby through the generation of waves in the experiment. These waves are important because they characterize the distribution of the temperature in the ocean and the atmosphere. For this reason we are going to study different cases to verificate that theory, by modifying the plane tilt or rotation speed. The numerical study is established by formulas of different experiments and studies of such waves, in which we consider the roudness of the Earth, the Coriolis component or the potencial vorticity, besides other parameters like the latitude (ß plane) or fluid depth. The experimental part will be performed on a rotating table on which we will place a PVC tank with water. In this tank we simulate the rotation of the Earth and latitude variation. The waves will be observed by the production of ice cubes with colourings. They allow the display of these waves.López Calderón, S. (2013). Estudio de la generación y propagación de ondas de Rossby a pequeña escala. Universitat Politècnica de València. http://hdl.handle.net/10251/34982Archivo delegad

Programación didáctica : tecnología, programación y robótica 1º ESO

Máster Universitario en Formación del Profesorado de ESO, Bachillerato, Formación Profesional y Enseñanza de Idiomas. Especialidad en Tecnología (M090

Vitamin C and the Red Wine Polyphenol Resveratrol - but not Curcumin and the Glycolysis Inhibitors 2- Deoxyglucose, Dichloroacetate and 3-Bromopyruvate - Induce Selective Cytotoxicity against Lung Cancer Cells.

Cancer statistics show that the most commonly diagnosed cancer in the world is lung cancer, that over 50% of patients diagnosed with this cancer have distant metastasis, and that only 4% of these patients manage to survive more than 5 years. The limited selective cytotoxicity of the drugs used for the treatment of these patients probably accounts for these high mortality rates. In this work, we have assessed the selective anticancer activity of several drugs currently undergoing clinical trials by using human A549 lung cancer cells and human MRC5 non-malignant lung fibroblasts. Vitamin C and the red wine polyphenol resveratrol induced selective cytotoxicity towards the cancer cell line. Vitamin C (1 mM) induced higher selective cytotoxicity than the anticancer agents cisplatin, oxaliplatin, etoposide and 5-fluorouracil. A lyophilized red wine extract, but not a hydroalcoholic extract from red grapes, also showed certain selectivity against lung cancer cells. Neither the curry polyphenol curcumin nor the glycolysis inhibitors 2-deoxyglucose, dichloroacetate and 3-bromopyruvate displayed selective cytotoxicity. We also report that A549 lung cancer cells have higher glycolytic rates (higher glucose consumption and higher lactate production) than human MRC5 non-malignant lung fibroblasts, and that the combination of each glycolytic inhibitor with the pro-oxidant agents pyrogallol and hydrogen peroxide does not result in a significant increase in their cytotoxicity or selectivity against the cancer cell line. Our results support the possible evaluation of vitamin C and resveratrol in clinical trial for the treatment of metastatic lung cancers, and suggest that curcumin and the glycolysis inhibitors 2-deoxyglucose, dichloroacetate and 3-bromopyruvate have a limited potential (at least as single agents) for the treatment of patients with this type of cance

Auditoría de estados financieros: Análisis de Calsa, S.A.

El presente trabajo tiene por objeto la presentación del proceso que se lleva a cabo durante un encargo de auditoría. Para ello, se han utilizado los conocimientos adquiridos durante el Máster de Auditoría y las prácticas realizadas.Para alcanzar tal fin, se ha realizado un análisis sobre cada una de las diferentes etapas que conforman el proceso de emisión de un informe de auditoría sobre cuentas anuales a través de una sociedad ficticia, haciendo hincapié en aquellas cuestiones que se han considerado más importantes.El contenido principal del trabajo se centra en aspectos prácticos, aunque también se recogen algunos conceptos teóricos fundamentales que ayudan a entender en qué consiste la auditoría.<br /

Simone de Beauvoir

9 p.Simone de Beauvoir fue una escritora, profesora y filósofa francesa, que desarrolló y discutió diferentes temas como lo son la política, la economía, la filosofía y el feminismo. Convirtiéndose en una de las imágenes más importantes del feminismo filosófico y del feminismo de la liberación durante el siglo XX haciendo parte de la segunda ola feminista.EL FEMINISMO SIMONE DE BEAUVOIR – PENSAMIENTO FEMINISTA BIBLIOGRAFÍ

Applied research to new construction materials subject

[EN] The degree in Building Engineering at the University of Burgos has been included the Bologna System 10 years ago, implemented simultaneously in the 2010-2011 academic year the entire degree - four courses. According with the initial strategies, the acquisition of competences through project research work in the construction materials subjects has been one of the elements developed and consolidated, especially in the elective subjects of higher courses where training of the student already allows this type of resources. However, the work begins the first year with specific classes to introduce the investigation within the subjects of construction materials, with agenda reflected in the educational guide. One of them, for example, is an intensive course of advanced searches in international scientific databases, which must be used in a practical way to test what has been learned, and which can be extrapolated to the rest of the subjects of the degree.[ES] El grado en Arquitectura Técnica de la Universidad de Burgos lleva un recorrido de 10 años en el Plan Bolonia, que implantó de manera simultánea en el curso 2010-2011 para los cuatro cursos del grado. Dentro de las estrategias iniciales del Grado, la adquisición de competencias a través del trabajo por proyectos en las asignaturas de materiales de construcción ha sido uno de los factores que se ha desarrollado y afianzado, especialmente en la asignaturas optativas de cursos más altos donde la formación del estudiante ya permite este tipo de recursos. No obstante, se comienza desde primer curso con clases específicas de introducción a la investigación dentro de las asignaturas de materiales de construcción, con temario contemplado en la guía docente. Una de ellas, por ejemplo, es un curso intensivo de búsquedas avanzadas en bases de datos científicas internacionales, que debe ser utilizado de manera práctica para poner a prueba lo aprendido, y que puede ser extrapolado al resto de asignaturas de la titulación.Gadea Sáinz, J.; Calderón Carpintero, V.; Junco Petrement, C.; Gutiérrez-González, S.; Rodríguez Saiz, Á.; Garabito López, J. (2021). Investigación aplicada a la formación en nuevos materiales de construcción. Editorial Universitat Politècnica de València. 37-43. https://doi.org/10.4995/EDIFICATE2021.2021.13531OCS374

A mixture of algae and extra virgin olive oils attenuates the cardiometabolic alterations associated with aging in male wistar rats

Aging is one of the major risk factors for suffering cardiovascular and metabolic diseases. Due to the increase in life expectancy, there is a strong interest in the search for anti-aging strategies to treat and prevent these aging-induced disorders. Both omega 3 polyunsaturated fatty acids (ω-3 PUFA) and extra virgin olive oil (EVOO) exert numerous metabolic and cardiovascular benefits in the elderly. In addition, EVOO constitutes an interesting ingredient to stabilize ω-3 PUFA and decrease their oxidation process due to its high content in antioxidant compounds. ω-3 PUFA are commonly obtained from fish. However, more ecological and sustainable sources, such as algae oil (AO) can also be used. In this study, we aimed to study the possible beneficial effect of an oil mixture composed by EVOO (75%) and AO (25%) rich in ω-3 PUFA (35% docosahexaenoic acid (DHA) and 20% eicosapentaenoic acid (EPA)) on the cardiometabolic alterations associated with aging. For this purpose; young (three months old) and old (24 months old) male Wistar rats were treated with vehicle or with the oil mixture (2.5 mL/kg) for 21 days. Treatment with the oil mixture prevented the aging-induced increase in the serum levels of saturated fatty acids (SFA) and the aging-induced decrease in the serum concentrations of mono-unsaturated fatty acids (MUFA). Old treated rats showed increased serum concentrations of EPA and DHA and decreased HOMA-IR index and circulating levels of total cholesterol, insulin and IL-6. Treatment with the oil mixture increased the mRNA levels of antioxidant and insulin sensitivity-related enzymes, as well as reduced the gene expression of pro-inflammatory markers in the liver and in cardiac and aortic tissues. In addition, the treatment also prevented the aging-induced endothelial dysfunction and vascular insulin resistance through activation of the PI3K/Akt pathway. Moreover, aortic rings from old rats treated with the oil mixture showed a decreased response to the vasoconstrictor AngII. In conclusion, treatment with a mixture of EVOO and AO improves the lipid profile, insulin sensitivity and vascular function in aged rats and decreases aging-induced inflammation and oxidative stress in the liver, and in the cardiovascular system. Thus, it could be an interesting strategy to deal with cardiometabolic alterations associated with aging.This project was funded by the call “Doctorados Industriales 2017” (IND2017/BIO7701), a grant from Community of Madrid (Spain). This program aims to promote the effective collaboration between Universities and Companies and provides funding for the development of the research project at the University and, to hire a PhD student (Daniel González-Hedström) by the Company (Pharmactive Biotech Products S.L.) over a three-year period. Community of Madrid also funded the contract of María de la Fuente-Fernández through the Youth Employment Program (PEJ-2018-AI/SAL-11315

Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain

Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of patients diagnosed with metastatic cancers. Since plants are an important source of anticancer drugs, we have screened 65 extracts from 45 plants collected in several areas of Western Andalusia (Spain) for cytotoxic activity on lung cancer cells versus lung normal cells. An extract from the leaves of Tetraclinis articulata (Vahl) Mast. (Cupressaceae) showed a marked cytotoxicity (IC50 = 0.37 ± 0.03 µg/mL) and selectivity (selectivity index = 378.3) against the lung cancer cells; cisplatin, 5-fluorouracil, and an extract from the leaves of Taxus baccata L. (Taxaceae) were less cytotoxic and selective. Extracts from Cascabela thevetia (L.) Lippold (Apocynaceae), Frangula alnus Mill. (Rhamnaceae), Iberis ciliata subsp. contracta (Pers.) Moreno (Brassicaceae), Juniperus macrocarpa Sm (Cupressaceae), and Pancratium maritimum L. (Amaryllidaceae) also showed selective cytotoxicity (selectivity index > 10). Active extracts were also tested against a panel of cancer cell lines from a variety tissues. The plants identified in this work are potential sources of natural compounds with selective toxicity towards cancer cells.Universidad de Sevilla VPPI-I.

Mapas de actividades comunitarias y activos para la salud: ¿Cómo trabajar con ellos?

El modelo de activos para la salud tiene relaciones íntimas con el paradigma de la Promoción de la Salud, de modelos de Desarrollo Comunitario o de la Teoría Salutogénica de Antonovsky, siendo su punto de partida la Salud Positiva de una comunidad y de las personas que la integran

Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle

Aging is associated with increased visceral adiposity and a decrease in the amount of brown adipose tissue and muscle mass, known as sarcopenia, which results in the development of metabolic alterations such as insulin resistance. In this study, we aimed to analyze whether 3-week supplementation with a phenolic-rich olive leaf extract (OLE) to 24 months-old male Wistar rats orally (100 mg/kg) attenuated the aging-induced alterations in body composition and insulin resistance. OLE treatment increased brown adipose tissue and attenuated the aging-induced decrease in protein content and gastrocnemius weight. Treatment with OLE prevented the aging-induced increase in the expression of PPAR-γ in visceral and brown adipose tissues, while it significantly increased the expression of PPAR-α in the gastrocnemius of old rats and reduced various markers related to sarcopenia such as myostatin, HDAC-4, myogenin and MyoD. OLE supplementation increased insulin sensitivity in explants of gastrocnemius and epididymal visceral adipose tissue from aged rats through a greater activation of the PI3K/Akt pathway, probably through the attenuation of inflammation in both tissues. In conclusion, supplementation with OLE prevents the loss of muscle mass associated with aging and exerts anti-inflammatory and insulin-sensitizing effects on adipose tissue and skeletal muscle