Post-fledging dependence period and onset of natal dispersal in Bearded Vultures (Gypaetus barbatus): new insights from GPS satellite telemetry.

Utilizamos telemetría satelital para estudiar el periodo de dependencia post emplumamiento de tres individuos silvestres y seis individuos cautivos de Gypaetus barbatus. El primer vuelo tuvo lugar cuando los pollos tenían 126 ± 7 días de edad (rango  =  111-134 días) y el inicio de la dispersión ocurrió a los 193 ± 40 días desde el primer vuelo (rango  =  143-231 días). Los jóvenes permanecieron en sus áreas natales (o de liberación, en el caso de aves criadas en cautiverio) durante los primeros dos meses desde la fecha de emplumamiento. Luego, comenzaron a incrementar progresivamente la distancia a sus áreas natales; durante este tiempo, la mayoría de los desplazamientos de larga distancia (>15 km) tuvieron lugar antes del mediodía. Los tamaños de las áreas de acción registrados en este estudio fueron superiores a los descritos con anterioridad para la especie, principalmente debido a la diferencia en los métodos de rastreo empleados: la telemetría satelital permitió la detección de movimientos de larga distancia más allá del rango de medición del rastreo por radio convencional. Finalmente, la adquisición de la independencia (i.e., emancipación) se solapó con la siguiente temporada de cría de los adultos

Exploring host genetic polymorphisms involved in SARS-CoV infection autcomes: implications for personalized medicine in COVID-19

Objective. To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in humans. Methods. This comprehensive literature search comprised available English papers published in PubMed/Medline and SCOPUS databases following the PRISMA-P guidelines and PICO/AXIS criteria. Results. Twenty-nine polymorphisms located in 21 genes were identified as associated with SARS-CoV susceptibility/resistance, disease severity, and clinical outcomes predominantly in Asian populations. Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. Conclusions. Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments

Evaluación multidisciplinar 3D de una estructura kárstica asociada a colapso y subsidencia (Cuenca del Ebro)

La propagación de cavidades de disolución localizadas por debajo de series aluviales genera una serie de evidencias cuya representación superficial, en ocasiones, puede no ser indicativa de su extensión real en profundidad. La propagación de cavidades a través de medios heterogéneos, en los que pueden existir niveles cementados, puede producir cambios en la progresión de dichas cavidades y la identificación en superficie de grietas, colapsos, o zonas de subsidencia que pueden involucrar decenas de miles de metros cúbicos de material inestable. Cualquier tipo de evaluación de soluciones mitigadoras en estos contextos debe considerar la amplitud de estos volúmenes y el origen del proceso con independencia de la actividad registrada en superficie. En este trabajo se aborda un estudio integrado con el objetivo de determinar la estructura de un sector con evidencias de actividad kárstica superficial y evaluar su extensión y desarrollo tridimensional integrando el análisis geomorfológico, de inspección de campo, geofísica (GPR) y sondeos. The propagation of solution cavities located below alluvial deposits produce surficial evidences that, in some cases, cannot be representative of their actual extension at depth. Cavity propagation through heterogeneous media, for example with interbedded cemented levels, can produce changes in the propagation of deformation producing the identification of cracks, collapses or subsidence zones at the surface. These processes can involve thousands of cubic meters of unstable materials. Any evaluation of mitigation tasks, in this context, needs to consider: i) the amplitude of the affected volumes and ii) the in depth origin with independence of the surficial recorded activity In this work an integrated analysis is developed to evaluate the size and 3D structure of a sector with surficial evidences of karstic activity integrating geomorphological analysis, field inspection, geophysics (GPR) and boreholes

Universality in Bacterial Colonies

The emergent spatial patterns generated by growing bacterial colonies have been the focus of intense study in physics during the last twenty years. Both experimental and theoretical investigations have made possible a clear qualitative picture of the different structures that such colonies can exhibit, depending on the medium on which they are growing. However, there are relatively few quantitative descriptions of these patterns. In this paper, we use a mechanistically detailed simulation framework to measure the scaling exponents associated with the advancing fronts of bacterial colonies on hard agar substrata, aiming to discern the universality class to which the system belongs. We show that the universal behavior exhibited by the colonies can be much richer than previously reported, and we propose the possibility of up to four different sub-phases within the medium-to-high nutrient concentration regime. We hypothesize that the quenched disorder that characterizes one of these sub-phases is an emergent property of the growth and division of bacteria competing for limited space and nutrients.Comment: 12 pages, 5 figure

Educación y cooperación para el desarrollo mediante estándares universales de accesibilidad

II FORO «IBEROAMÉRICA EN LA ESCENA ECONÓMICA INTERNACIONAL: INVERSIONES Y EDUCACIÓN PARA EL DESARROLLO». UNIVERSIDAD REY JUAN CARLOS, MADRID (ESPAÑA), 14 DE DICIEMBRE DE 200

Accesibilidad a Internet: requisitos para la calidad en la docencia e investigación

A good Internet platform for teaching and research must be accessible, independently of the computer platform used, language and other peculiarities (personal or external). This work analyzes the current limitations of Internet access, as well as the potentialities that would represent an access being truly independent of the computer platform, discapacities, availability and speed of access, language and legislation. Thus, the benefits for a more accesible network for lecturing and investigation, overcoming the geographic location or possible discapacity, would be immediate and would have a broad impact spectrum. A more accesible Internet would enhace not only the dissemination of the information, approaching us to the 'global village', but also others aspects like university principles and values that sould be considered: an improvement of the equality of opportunities and the access to the culture and the education, that are the basis of the progress and the individual and collective liberties.Una buena plataforma de docencia e investigación en la red debe ser accesible, independientemente del entorno informático, idioma y condicionantes( personales o externos). Es este trabajo se analizan, por una parte, las limitaciones actuales que se presentan en el acceso a Internet, y por otra las potencialidades que tendría un acceso un acceso independiente de las plataforma informáticas, discapacidades, disponibilidad y velocidad de acceso, idioma y legislación. Así, los beneficios para la docencia y la investigación de una red más accesible, por encima de la localización geográfica o posible discapacidad, serán inmediatos y redundaría en otros campos. Una Internet más accesible abriría una nueva vía no sólo para la difusión de la información, acercándonos a la 'aldea global', sino también para otros aspectos de lo que entenderemos como principios y valores universitarios y que deben ser considerados: una mejora en la igualdad de oportunidades y en el acceso a la cultura y la formación, que son las bases del progreso y de las libertades tanto individuales como colectivas

Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice

The remodeling of the extracellular matrix is a central function in endochondral ossification and bone homeostasis. During secondary fracture healing, vascular invasion and bone growth requires the removal of the cartilage intermediate and the coordinate action of the collagenase matrix metalloproteinase (MMP)-13, produced by hypertrophic chondrocytes, and the gelatinase MMP-9, produced by cells of hematopoietic lineage. Interfering with these MMP activities results in impaired fracture healing characterized by cartilage accumulation and delayed vascularization. MMP-10, Stromelysin 2, a matrix metalloproteinase with high homology to MMP-3 (Stromelysin 1), presents a wide range of putative substrates identified in vitro, but its targets and functions in vivo and especially during fracture healing and bone homeostasis are not well defined. Here, we investigated the role of MMP-10 through bone regeneration in C57BL/6 mice. During secondary fracture healing, MMP-10 is expressed by hematopoietic cells and its maximum expression peak is associated with cartilage resorption at 14 days post fracture (dpf). In accordance with this expression pattern, when Mmp10 is globally silenced, we observed an impaired fracture-healing phenotype at 14 dpf, characterized by delayed cartilage resorption and TRAP-positive cell accumulation. This phenotype can be rescued by a non-competitive transplant of wild-type bone marrow, indicating that MMP-10 functions are required only in cells of hematopoietic linage. In addition, we found that this phenotype is a consequence of reduced gelatinase activity and the lack of proMMP-9 processing in macrophages. Our data provide evidence of the in vivo function of MMP-10 during endochondral ossification and defines the macrophages as the lead cell population in cartilage removal and vascular invasio